20 Results for "

Gingival

" in MedChemExpress (MCE) Product Catalog:
Products (20)

20 Results for "Gingival" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-A0020
CAS No.: 104121-92-8
Synonyms: ED-71; 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3
Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .
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3
3 Cited Publications
Cat. No.: HY-32350
CAS No.: 60133-18-8
Synonyms: 1α,25-Dihydroxy Vitamin D2
Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
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Cat. No.: HY-150205
CAS No.: 2361972-29-2
Purity:  99.46%
Target:  

Succinate Receptor 1

Research Areas:  

Inflammation/Immunology

Succinate/succinate receptor antagonist 1 is an antagonist of the succinate/succinate receptor. Succinate/succinate receptor antagonist 1 can inhibit the activation of succinate receptor 1 (SUCNR1). Succinate/succinate receptor antagonist 1 can block succinate signaling. Succinate/succinate receptor antagonist 1 can be used for the study of periodontal disease .
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Cat. No.: HY-P3466
CAS No.: 137061-46-2
Target:  

Bacterial Fungal

Research Areas:  

Infection Inflammation/Immunology

Nisin Z is an antimicrobial and anti-inflammatory peptide. Nisin Z is effective against Gram-positive bacteria and fungi, such as C. albicans .
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Cat. No.: HY-W129596
CAS No.: 101418-00-2
Policresulen is a competitive inhibitor for DENV2 NS2B/NS3 protease with an IC50 of 0.48 μg/mL. Policresulen can be used as a local hemostatic and antibacterial agent for research of cervical and vaginal inflammation, skin lesions, oral mucosa and gingival inflammation .
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Cat. No.: HY-W024604
CAS No.: 22748-16-9
Synonyms: 4,4-Dimethylcyclopent-2-enone
4,4-Dimethyl-2-cyclopenten-1-one (4,4-Dimethylcyclopent-2-enone) is a β-unsubstituted cyclic α,β-unsaturated ketone and anticancer agent. 4,4-Dimethyl-2-cyclopenten-1-one does not activate Caspase 3, 8 or 9, nor does it induce internucleosomal DNA fragmentation. 4,4-Dimethyl-2-cyclopenten-1-one exhibits anticancer activity against oral squamous cell carcinoma and promyelocytic leukemia .
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Cat. No.: HY-P11170
CAS No.: 3002053-77-9
Target:  

Fungal

Research Areas:  

Infection

D-Cateslytin is an antimicrobial peptide that exhibits potent inhibition activity against Candida albicans (MIC = 2.9 μM). D-Cateslytin can rapidly enter C. albicans, and shows no cytotoxicity to human gingival fibroblasts, and is stable in saliva. D-Cateslytin can be used for research on Candida albicans related diseases, such as oral candidosis .
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Cat. No.: HY-N4298
CAS No.: 102067-92-5
Epitheaflagallin 3-O-gallate is a minor polyphenol in black tea. Epitheaflagallin 3-O-gallate exhibits versatile physiological functions in vivo and in vitro, including antioxidative activity, pancreatic lipase inhibition, Streptococcus sorbinusglycosyltransferase inhibition, and an inhibiting effect on the activity of matrix metalloprotease-1 and -3 and their synthesis by human gingival fibroblasts .
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Cat. No.: HY-W207699
CAS No.: 27052-20-6
MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance .
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Cat. No.: HY-A0020R
CAS No.: 104121-92-8
Synonyms: ED-71 (Standard); 2-(3-hydroxypropoxy)-1,25-dihydroxyvitamin D3 (Standard)
Eldecalcitol (Standard) is the analytical standard of Eldecalcitol. This product is intended for research and analytical applications. Eldecalcitol (ED-71) is an orally active vitamin D3 analogue, inhibits bone resorption and increases bone mineral density. Eldecalcitol (ED-71) displays anti-tumor effect and inhibits cell proliferation, migration and induces apoptosis by suppressing GPx-1 .
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Cat. No.: HY-N13286
CAS No.: 51971-09-6
Glycozolidal (compound 12) is a carbazole alkaloid with antibacterial activity against P. gingivalis. Glycozolidal is cytotoxic against human gingival fibroblasts (HGFs) and monocytes (U937) in vitro with IC50 values ​​of 120.86 µg/mL and 97.74 µg/mL, respectively .
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Cat. No.: HY-106761
CAS No.: 90729-41-2
Target:  

Calcium Channel

Research Areas:  

Cardiovascular Disease Others

Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs .
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Cat. No.: HY-136727A
Target:  

Caspase Apoptosis

Research Areas:  

Cancer

Ac-LEVD-CHO (TFA) is an inhibitor of caspase-4. Ac-LEVD-CHO (TFA) can inhibit the expression and secretion of IL-1α expression as well as the activation of caspase-4 induced by the T. denticola periodontal pathogen surface protein Td92 in human gingival fibroblasts. Ac-LEVD-CHO (TFA) can also reduce the apoptosis due to the expression of the dominant negative adenoviral RNA-dependent protein kinase in A549 and PC3 cancer cell lines .
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Cat. No.: HY-32350S1
CAS No.: 1261254-46-9
Synonyms: 1α,25-Dihydroxy Vitamin D2-d3
Ercalcitriol-d3 (1α,25-Dihydroxy Vitamin D2-d3) is the deuterium labeled Ercalcitriol (HY-32350). Ercalcitriol (1α,25-Dihydroxy Vitamin D2) is a vitamin D receptor (VDR) agonist with high binding affinity. After binding to VDR, Ercalcitriol forms a complex with retinoid X receptor (RXR) to regulate target gene transcription. For example, Ercalcitriol induces human gingival/oral epithelial cells to produce human cat antimicrobial peptide (hCAP-18/LL-37), which has antimicrobial activity against periodontal pathogens such as Porphyromonas gingivalis. Ercalcitriol enhances the innate immune defense of the oral mucosa by promoting the expression of antimicrobial peptides, and is mainly used in the study of periodontal diseases and immune-related oral diseases .
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Cat. No.: HY-N17854
CAS No.: 356785-71-2
3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester is a triterpene glycoside found in the roots of Sanguisorba officinalis. 3β-O-α-L-Arabinopyranosylsiaresinolic acid 28-O-β-D-glucopyranosyl ester is non-cytotoxic and does not exhibit cytotoxic activity against human oral squamous cell carcinoma cells or normal human gingival fibroblasts .
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Cat. No.: HY-P83568
Synonyms: alternate SOS1; GF1; GGF1; GINGF; Gingival fibromatosis; HGF; NS4; Sos1

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-N17633
CAS No.: 95378-08-8
Mulberrofuran L is a 2-arylbenzofuran compound. Mulberrofuran L exhibits certain cytotoxicity against tumor cells. Mulberrofuran L can be used in tumor research .
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Cat. No.: HY-P704193
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SOS1; Son Of Sevenless Homolog 1 (Drosophila), Isoform CRA_d; Prev. GINGF; Guanine Nucleotide Exchange Factor; HGF; Uncharacterized Protein SOS1; GF1; Alternate SOS1; Gingival Fibromatosis, Hereditary, 1; GGF1; Son Of Sevenless Homolog 1; NS4; SOS-1; SOS
Species:  
Source:  
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Cat. No.: HY-126443A
CAS No.: 1352296-65-1
Target:  

Fungal

Research Areas:  

Infection

Antifungal agent 173 is an orally active antifungal (fungal) agent. Antifungal agent 173 disrupts fungal cell membrane integrity, inhibits yeast-hypha transition in Candida species, and suppresses biofilms. Antifungal agent 173 prevents mouse mortality in a mouse model of systemic candidiasis and reduces tongue lesions in a mouse model of oropharyngeal candidiasis. Antifungal agent 173 is applicable to research related to candidiasis .
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Cat. No.: HY-N17359
CAS No.: 329319-21-3
Mulberrofuran W is a 2-arylbenzofuran with a farnesyl group that exists in the root bark of Morus mongolica. It also acts as a cytotoxic agent with low cytotoxicity and weak tumor specificity .
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