Antifungal agent 173
Antifungal agent 173 is an orally active antifungal (fungal) agent. Antifungal agent 173 disrupts fungal cell membrane integrity, inhibits yeast-hypha transition in Candida species, and suppresses biofilms. Antifungal agent 173 prevents mouse mortality in a mouse model of systemic candidiasis and reduces tongue lesions in a mouse model of oropharyngeal candidiasis. Antifungal agent 173 is applicable to research related to candidiasis.
Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.
- CAS. Nr.: 1352296-65-1
- Formel: C23H32ClNO5
- Molecular Weight:437.96
-
Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biologische Aktivität
-
Chemical Information
- Protokoll
- Reinheit & Dokumentation
- Verweise
-
Help & FAQs
Biologische Aktivität
Beschreibung
In Vitro
Antifungal agent 173 (0.2-6.25 μg/mL; 48-72 h) displays broad antifungal activity against Candida species, Cryptococcus neoformans, and Penicillium marneffei (MIC range 0.2-1.6 μg/mL), and is effective against antifungal-resistant Candida isolates with MIC values of 0.5-1 μg/mL[1].
Antifungal agent 173 (0.2-100 μg/mL; 24 h) potently inhibits Candida albicans, Candida glabrata, and Candida krusei biofilms, with an MICbiofilm of 3.2 μg/mL for 24-h biofilms, and reduces C. albicans BF-1 biofilm viability on PMMA denture discs by up to 97% when applied both before and after the adhesion phase[1].
Antifungal agent 173 (0.5-2 μg/mL; 24 h) prevents Candida albicans SC5314 invasion of human oral keratinocytes[1].
Antifungal agent 173 (0.1 μg/mL; 1 h) disrupts the cell membrane integrity of Candida albicans SC5314[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Antifungal agent 173 (200 μg/mL; oral pipetting; 5 total timed doses post-inoculation) reduces oral candidiasis tongue lesion severity to a score of 1 and lowers fungal burden in mouse oral cavities to 4.5×102 CFUs/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Animal Model:C57BL/6 (8-week-old male, systemic candidiasis model via tail vein injection of Candida albicans SC5314)[1]
-
Dosage:0.01 mg/kg; 0.1 mg/kg; 1 mg/kg; 10 mg/kg
-
Administration:i.p.; twice daily; 5 days
-
Result:Achieved 100% survival to day 5.
Reduced renal fungal burden by 3 orders of magnitude compared to untreated controls.
Eliminated visible Candida lesions on kidney surfaces.
Detected very few Candida cells in PAS-stained kidney sections, compared to abundant hyphae in untreated controls.
-
Animal Model:C57BL/6 (oral candidiasis model via oral swabbing with Candida albicans SC5314, preceded by immunosuppression with prednisolone and tetracycline hydrochloride)[1]
-
Dosage:200 μg/mL
-
Administration:oral pipetting; 5 total timed doses post-inoculation
-
Result:Reduced tongue lesion severity to a score of 1, compared to 3 in untreated controls and 2 in nystatin-treated mice.
Lowered fungal burden in oral cavities to 4.5×102 CFUs/mL, compared to 4.8×103 CFUs/mL in untreated controls and 6.0×102 CFUs/mL in nystatin-treated mice.
Showed comparatively fewer Candida hyphae in PAS-stained tongue sections, compared to abundant hyphae in untreated controls.
Chemical Information
-
CAS. Nr. 1352296-65-1
-
Molecular Weight 437.96
-
Formel C23H32ClNO5
-
SMILES
O=Cl(=O)([O-])=O.CN(C)C(C=C1)=CC=C1/C=C/C2=CC(C(C)(C)C)=[O+]C(C(C)(C)C)=C2
-
Versand
Room temperature in continental US; may vary elsewhere.
-
Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Antifungal agent 173 Related Classifications
HY-126443A Related Classifications
Powered by Bioz
Keywords
- Antifungal agent 173
- 1352296-65-1
- Antifungal agent173
- Antifungal agent-173
- Fungal
- HWP1
- systemic candidiasis mouse models
- human cell lines
- Cryptococcus neoformans
- Candida species
- human oral keratinocytes
- Candida albicans SC5314
- oral candidiasis mouse models
- human gingival fibroblasts
- Penicillium marneffei
- Inhibitor
- inhibitor
- inhibit