27052-20-6
Chemical Structure
MAO-B-IN-46
- CAS No.: 27052-20-6
- Formula:C15H9ClO2
- Molecular Weight:256.68
IUPAC Name: benzofuran-2-yl(4-chlorophenyl)methanone
InChIKey: FQHJAAOLWZILJU-UHFFFAOYSA-N
SMILES: C1=CC=C2C(=C1)C=C(C(=O)C3=CC=C(C=C3)Cl)O2
Biological Activity: MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance[1][2].
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MAO-B-IN-46 | MAO-B-IN-46 (Compound 16) is a selective hMAO-B inhibitor (IC50: 26.8 nM), with weak activity against hMAO-A (IC50: 7.2054 μM). MAO-B-IN-46 (Compound 8) also acts as an α-amylase inhibitor (IC50: 19.46 μM). MAO-B-IN-46 exhibits certain neuroprotective effects and shows no significant toxicity to human gingival fibroblasts and SH-SY5Y cells. Additionally, MAO-B-IN-46 can scavenge DPPH and ABTS free radicals, with IC50 values of 17.86 μM and 17.71 μM, respectively. MAO-B-IN-46 can be used in the research of neurodegenerative diseases such as Parkinson's disease, diabetes, and diseases related to oxidative stress resistance. | |||||||||||||||||||||
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- [1]. Guglielmi P, et al. Design, synthesis, and biological activity of 2-aroylbenzofuran-3-ols and 2-aroylbenzofuran derivatives: A new route towards hMAO-B inhibition. Eur J Med Chem. 2025 Nov 5;297:117983. [Content Brief]
- [2]. Ali I, et al. Potent α-amylase inhibitors and radical (DPPH and ABTS) scavengers based on benzofuran-2-yl(phenyl)methanone derivatives: Syntheses, in vitro, kinetics, and in silico studies. Bioorg Chem. 2020 Nov;104:104238. [Content Brief]
Keywords
