SOS1 Protein, Human (Active, sf9, His)
SOS1 Protein, Human (Active, sf9, His) is the recombinant human-derived SOS1 protein, expressed by Sf9 insect cells, with N-His tag.
- Species: Human
- Source: Sf9 insect cells
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
SOS1 Protein, Human (Active, sf9, His) is the recombinant human-derived SOS1 protein, expressed by Sf9 insect cells, with N-His tag.
SOS1 promotes the exchange of Ras-bound GDP by GTP (PubMed:8493579). It likely regulates the phosphorylation of MAP kinase MAPK3/ERK1 in response to EGF by promoting Ras activation (PubMed:17339331). Additionally, SOS1 serves as the catalytic component of a trimeric complex involved in signal transduction from Ras to Rac by enhancing the guanine nucleotide exchange factor (GEF) activity specific to Rac (By similarity).
Technical Parameters
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Species Human
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Source Sf9 insect cells
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Tag N-His
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Accession
Q07889-1 (K504-T1049)
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Gene ID6654
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Molecular Construction
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N-term
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His
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SOS1 (K504-T1049)
Accession # Q07889-1 -
C-term
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Protein Length
Partial
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Synonyms
SOS1; Son Of Sevenless Homolog 1 (Drosophila), Isoform CRA_d; Prev. GINGF; Guanine Nucleotide Exchange Factor; HGF; Uncharacterized Protein SOS1; GF1; Alternate SOS1; Gingival Fibromatosis, Hereditary, 1; GGF1; Son Of Sevenless Homolog 1; NS4; SOS-1; SOS
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AA Sequence
KDDTNEYKHAFEIILKDENSVIFSAKSAEEKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEPDSEENIIFEENMQPKAGIPIIKAGTVIKLIERLTYHMYADPNFVRTFLTTYRSFCKPQELLSLIIERFEIPEPEPTEADRIAIENGDQPLSAELKRFRKEYIQPVQLRVLNVCRHWVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAHELSEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNPMGNSMEKEFTDYLFNKSLEIEPRNPKPLPRFPKKYSYPLKSPGVRPSNPRPGT
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Predicted Molecular Mass
57 kDa
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Molecular Weight
Approximately 57 kDa, based on SDS-PAGE under reducing conditions.
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Structure/Form
Monomer
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Solution.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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