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Results for "

Gq proteins

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (3) Adhesion G Protein-coupled Receptors (AGPCRs) (1) Adrenergic Receptor (1) Amyloid-β (1) Angiotensin Receptor (1) Apoptosis (1) Autophagy (1) Calcium Channel (1) Cholecystokinin Receptor (1) Cholinesterase (ChE) (1) Drug Derivative (2) ERK (1) GLP Receptor (1) mAChR (3) Mas-related G-protein-coupled Receptor (MRGPR) (1) MMP (1) P2X Receptor (1) PKA (2) Reference Standards (1) RGS Protein (1) Serotonin Transporter (1) YAP (1)
By Research Areas:	Cancer (2) Inflammation/Immunology (1) Metabolic Disease (3) Neurological Disease (7)

By Targets:

5-HT Receptor (3)

Adhesion G Protein-coupled Receptors (AGPCRs) (1)

Adrenergic Receptor (1)

Amyloid-β (1)

Angiotensin Receptor (1)

Apoptosis (1)

Autophagy (1)

Calcium Channel (1)

Cholecystokinin Receptor (1)

Cholinesterase (ChE) (1)

Drug Derivative (2)

ERK (1)

GLP Receptor (1)

mAChR (3)

Mas-related G-protein-coupled Receptor (MRGPR) (1)

MMP (1)

P2X Receptor (1)

PKA (2)

Reference Standards (1)

RGS Protein (1)

Serotonin Transporter (1)

YAP (1)

By Research Areas:

Cancer (2)

Inflammation/Immunology (1)

Metabolic Disease (3)

Neurological Disease (7)

Inhibitors & Agonists

Peptides

Targets Recommended: Slit Proteins Synaptic Vesicle Proteins HSP YTHDF

Cat. No.	Nombre del producto	Target	Áreas de investigación	Chemical Structure

HY-107111

GSK1034702	mAChR	Neurological Disease
GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC₅₀=8.1) that can cross the blood-brain barrier. GSK1034702 activates the *Gq/11* protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions) .

HY-134807

Indophagolin	P2X Receptor 5-HT Receptor Autophagy	Cancer
Indophagolin is a potent, indoline-containing autophagy inhibitor (IC₅₀=140 nM). Indophagolin antagonizes the purinergic receptor P2X₄ as well as P2X₁ and P2X₃ with IC₅₀s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the G_q-protein-coupled P2Y₄, P2Y₆, and P2Y₁₁ receptors (IC₅₀s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT₆ (IC₅₀=1.0 μM) and a moderate effect on receptors 5-HT_1B, 5-HT_2B, 5-HT_4e, and 5-HT₇ .

HY-P2381

Sar-Arg-Val-Tyr-Val-His-NH2 2 Publications Verification	Angiotensin Receptor	Others
Sar-Arg-Val-Tyr-Val-His-NH2 is a *G_q-biased* agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein .

HY-P10365

VPM-p15	Adhesion G Protein-coupled Receptors (AGPCRs)	Others
Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members .

HY-175515

5-HT2C agonist-11	5-HT Receptor	Neurological Disease
5-HT2C agonist-11 (Compound 1) is an orally active, brain-penetrant and selective 5-HT_2C receptor agonist (EC₅₀=15 nM). 5-HT2C agonist-11 activates the Gq protein signaling pathway, promoting intracellular calcium release. 5-HT2C agonist-11 is promising for research of depression, post-traumatic stress disorder (PTSD) and neuropathic pain .

HY-P11540

CCKBR agonist-1	Cholecystokinin Receptor MMP Amyloid-β	Neurological Disease
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC₅₀ of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC₅₀ of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease .

HY-114865

BMS-192364	RGS Protein Calcium Channel	Neurological Disease
BMS-192364 is targeting the G_α-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux .

HY-173003

EP-3945	Mas-related G-protein-coupled Receptor (MRGPR)	Inflammation/Immunology
EP-3945 is a potent agonist of Mas-related G protein-coupled receptor (MRGPR), more effective than the MRGPRD small molecule agonist β-Alanine (HY-N0230). MRGPR plays a crucial role in inflammatory pruritus and pain sensation. Additionally, MRGPR binds to Gq (MRGPRX2, MRGPRX4, MRGPRX1 couple with Gq; MRGPRX2, MRGPRD couple with Gi), with EP-3945 measured EC₅₀ for Gq being 211.6 nM .

HY-107111A

GSK1034702 hydrochloride	Cholinesterase (ChE) mAChR	Neurological Disease
GSK1034702 hydrochloride is an orally active and allosteric agonist of M1 mAChR (pEC₅₀=8.1) that can cross the blood-brain barrier. GSK1034702 hydrochloride activates the *Gq/11* protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 hydrochloride can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 hydrochloride can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions) .

HY-137638

Sp-5,6-DCl-cBIMPS	PKA	Metabolic Disease
Sp-5,6-DCl-cBIMPS is a potent and specific *cAMP-dependent protein* kinases (cAMP-PK)** activator. Sp-5,6-DCl-cBIMPS stimulates insulin release. Sp-5,6-DCl-cBIMPS inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets .

HY-137638A

Sp-5,6-DCl-cBIMPS sodium Sp-5,6-DCI-cBIMPS	PKA	Metabolic Disease
Sp-5,6-DCl-cBIMPS sodium is a potent and specific *cAMP-dependent protein* kinases (cAMP-PK)** activator. Sp-5,6-DCl-cBIMPS sodium stimulates insulin release. Sp-5,6-DCl-cBIMPS sodium inhibits U-46619 (HY-108566)-induced activation of Rho, Gq and G12/G13 in platelets .

HY-182405

GQ127	Apoptosis YAP ERK	Cancer
GQ127 is an orally active Gαq/11 inhibitor with an IC₅₀ of 22.6 μM. GQ127 binds directly to Gαq/11 protein and inhibits its activity. GQ127 induces Apoptosis, suppresses viability, migration and invasion of uveal melanoma cells. GQ127 increases the phosphorylation level of YAP and decreases the phosphorylation level of ERK. GQ127 inhibits the growth of uveal melanoma xenografts in mouse models. GQ127 can be used for research related to uveal melanoma .

HY-181878

Z8779877149 Z7149	Serotonin Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
Z8779877149 (Z7149) is a blood-brain barrier-permeable multi-target ligand that targets SERT (K_i=198 nM), α2A adrenergic receptor (K_i=180 nM; EC₅₀=440 nM) and 5-HT_2A receptor (EC₅₀=172 nM, E_max=76%). Z8779877149 inhibits 5-HT reuptake and activates G_i and Gq protein signaling pathways, respectively. Z8779877149 effectively alleviates pain responses as well as depression- and anxiety-like behaviors, while exhibiting favorable safety without inducing sedation or motor impairment. Z8779877149 is available for the research of pain, depression and anxiety disorders .

HY-179541

PtdIns-(5)-P1-(1,2-dioctanoyl) ammonium	Drug Derivative	Others
PtdIns-(5)-P1-(1,2-dioctanoyl) ammonium is a synthetic phosphatidylinositol (PtdIns) derivative. PtdIns-(5)-P1-(1,2-dioctanoyl) ammonium can be used as a membrane phospholipid model in in vitro enzymology studies .

HY-179542

PtdIns-(4)-P1-(1,2-dihexanoyl) sodium	Drug Derivative	Others
PtdIns-(4)-P1-(1,2-dihexanoyl) sodium is a synthetic phosphatidylinositol (PtdIns) derivative. PtdIns-(4)-P1-(1,2-dihexanoyl) sodium can be used as a membrane phospholipid model in in vitro enzymology studies .

HY-145156

CHU-128	GLP Receptor	Metabolic Disease
CHU-128 is an effective and selective GLP-1R agonist. CHU-128 exhibits strong signal specificity and can activate the Gs/cAMP pathway, but it cannot activate the Gq/calcium signal, ERK phosphorylation, or recruit β-inhibitory proteins. CHU-128 can be used for research on type 2 diabetes .

HY-107111R

GSK1034702 (Standard)	Reference Standards mAChR	Neurological Disease
GSK1034702 (Standard) is the analytical standard of GSK1034702 (HY-107111). This product is intended for research and analytical applications. GSK1034702 is an orally active and allosteric agonist of M1 mAChR (pEC₅₀=8.1) that can cross the blood-brain barrier. GSK1034702 activates the Gq/11 protein-mediated signaling pathway, enhancing neuronal firing and long-term potentiation (LTP) in the CA1 region of the hippocampus. GSK1034702 can modulate hippocampal function, improve memory encoding in the nicotine withdrawal cognitive dysfunction model, and show pro-cognitive effects in rodents. GSK1034702 can be used for the study of the mechanisms of cognitive impairment diseases such as Alzheimer's disease, and has certain peripheral M receptor activation-related side effects (such as gastrointestinal reactions) .

Cat. No.	Nombre del producto	Target	Research Area

HY-P2381

Sar-Arg-Val-Tyr-Val-His-NH2 2 Publications Verification	Angiotensin Receptor	Others
Sar-Arg-Val-Tyr-Val-His-NH2 is a *G_q-biased* agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein .

HY-P10365

VPM-p15	Adhesion G Protein-coupled Receptors (AGPCRs)	Others
Vmm-p15 is a peptide agonist optimized for the adhesion G protein-coupled receptor GPR64 (also known as ADGRG2 or HE6). The affinity of VPM-p15 with GPR64 is significantly higher than that of the original p15 peptide. The cAMP level induced by VMM-P15 increased significantly, activated GPR64, and triggered downstream Gs, Gq, and G12/13 signaling. VPM-p15 can be used to study the activation mechanism of adherent GPCR family members .

HY-P11540

CCKBR agonist-1	Cholecystokinin Receptor MMP Amyloid-β	Neurological Disease
CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor (CCKBR) agonist with an EC₅₀ of 35 pM. CCKBR agonist-1 significantly increases the survival rate of neurons, with an EC₅₀ of 37 pM. CCKBR agonist-1 can improve the cognitive decline in mice by upregulating α-secretase (ADAM10) and calcium signaling molecule PLCB4, reduce the number of amyloid β (Aβ) plaques, and promote long-term potentiation (LTP). CCKBR agonist-1 can be used for the study of Alzheimer's disease .

HY-P2382

TRV120056	Peptides	Others
TRV120056 is a *G_q-biased* agonists, exhibits 10-fold larger molecular efficacies at the AT₁R-Gq fusion protein compared with the AT₁R-βarr2 fusion protein .

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