202822-21-7
202822-21-7
Chemical Structure
BMS-192364
- CAS No.: 202822-21-7
- Formula:C15H9ClF3N3O2
- Molecular Weight:355.70
IUPAC Name: 2-(5-chloro-2-hydroxyphenyl)-5-(4-(trifluoromethyl)phenyl)-1,2-dihydro-3H-1,2,4-triazol-3-one
InChIKey: XNRWPJIJOVVQRQ-UHFFFAOYSA-N
SMILES: O=C1N(C2=CC(Cl)=CC=C2O)NC(C3=CC=C(C(F)(F)F)C=C3)=N1
Biological Activity: BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BMS-192364 | 99.01% | BMS-192364 is targeting the Gα-RGS interaction to produce an inactive Gα-RGS complex. BMS-192364 reduces urinary bladder contraction and exert RGS-agonist properties by increasing the action of GAPs on Gq proteins. BMS-192364 inhibits calcium flux. | ||||||||||||||||||||
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References
- [1]. Kevin Fitzgerald, et al. Chemical genetics reveals an RGS/G-protein role in the action of a compound. PLoS Genet. 2006 Apr;2(4):e57. [Content Brief]
- [2]. Maciej Salaga, et al. RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Bioessays. 2016 Apr;38(4):344-54. [Content Brief]
- [3]. David P Basile, et al. A GAP in our knowledge of vascular signaling in acute kidney injury. Kidney Int. 2011 Aug;80(3):233-5. [Content Brief]
Keywords
