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Results for "

HCT15

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) AMPK (1) Apoptosis (8) Bcl-2 Family (1) Carbonic Anhydrase (1) Caspase (1) CDK (1) Drug Derivative (2) Drug Isomer (1) Endogenous Metabolite (1) ERK (1) HIF/HIF Prolyl-Hydroxylase (1) Isotope-Labeled Compounds (1) JNK (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (1) NF-κB (1) P-glycoprotein (2) p38 MAPK (1) p97 (2) Raf (1) Ras (1) Reactive Oxygen Species (ROS) (2) Reference Standards (1) Serotonin Transporter (1) Tyrosinase (1)
By Research Areas:	Cancer (26) Neurological Disease (1)

By Targets:

Akt (1)

AMPK (1)

Apoptosis (8)

Bcl-2 Family (1)

Carbonic Anhydrase (1)

Caspase (1)

CDK (1)

Drug Derivative (2)

Drug Isomer (1)

Endogenous Metabolite (1)

ERK (1)

HIF/HIF Prolyl-Hydroxylase (1)

Isotope-Labeled Compounds (1)

JNK (1)

Microtubule/Tubulin (1)

Mitochondrial Metabolism (1)

NF-κB (1)

P-glycoprotein (2)

p38 MAPK (1)

p97 (2)

Raf (1)

Ras (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (1)

Serotonin Transporter (1)

Tyrosinase (1)

By Research Areas:

Cancer (26)

Neurological Disease (1)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-101055

Kinetin riboside 3 Publications Verification N6-Furfuryladenosine	Apoptosis	Cancer
Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC₅₀ of 2.5 μM.

HY-N2693

6,8-Diprenylorobol	Apoptosis Reactive Oxygen Species (ROS) Caspase Akt ERK JNK p38 MAPK Bcl-2 Family	Cancer
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS .

HY-P10436

Braftide	Raf	Cancer
Braftide is an allosteric inhibitor for BRAF kinase by targeting the dimer interface of BRAF kinase and inhibiting the formation of BRAF dimers. Braftide inhibits wild-type BRAF and oncogenic BRAF ^G469A with IC₅₀ of 364 nM and 172 nM, respectively. Braftide inhibits MAPK signaling pathway, inhibits proliferation of KRAS mutant tumor cells (EC₅₀ is 7.1 and 6.6 μM, for HCT116 and HCT-15), in combination of TAT sequence. Braftide can be used for cancer research .

HY-19797

ML241	p97	Cancer
ML241 is a potent, selective and competitive p97 ATPase inhibitor with an IC₅₀ of 0.11 μM. ML241 can be used for the research of cancer .

HY-170027

LW1564	HIF/HIF Prolyl-Hydroxylase AMPK	Cancer
LW1564 is an inhibitor for HIF-1α with an IC₅₀ of 1.2 µM in HepG2. LW1564 inhibits mitochondrial respiration, reduces ATP production, stimulates HIF-1α degradation, and inhibits proliferation of various cancer cells with GI₅₀ of 0.4-4.6 μM. LW1564 activates AMPK signaling pathway and inhibits lipid synthesis. LW1564 exhibits antitumor in HepG2 xenograft mouse model .

HY-179257

p97-IN-2	p97	Cancer
p97-IN-2 (Compound 14) is a p97 ATPase (IC₅₀ = 0.6 μM) inhibitor. p97-IN-2 can inhibit cell proliferation, such as HCT15 (IC₅₀ = 1.1 μM) and SW403 (IC₅₀ = 0.8 μM) cells. p97-IN-2 can be used for cancer research .

HY-W278944

Antiproliferative agent-15	Drug Derivative	Cancer
Antiproliferative agent-15 is an thienopyrimidine derivated anticancer agent. Antiproliferative agent-15 shows antiproliferative activity against human colon (HCT116 and HCT15) and brain (LN-229 and GBM-10) cancer cell lines .

HY-N6578

3-epi-Isocucurbitacin B	Others	Cancer
3-epi-Isocucurbitacin B (Compound 5) is a cucurbitane triterpene derived from Trichosanthes kirilowii. 3-epi-Isocucurbitacin B shows significant cytotoxicity to human tumor cells A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT15 .

HY-101741

A-259745 A-289099	Microtubule/Tubulin Apoptosis	Cancer
A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED₅₀ values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer .

HY-179452

KRAS G13D-IN-2	Ras CDK Mitochondrial Metabolism	Cancer
KRAS G13D-IN-2 (compound 8B) is a potent orally active KRAS G13D inhibitor with IC₅₀ values of 1.95 μM (HCT-116 ^G13D) and 2.16 μM (HCT-15 ^G13D). KRAS G13D-IN-2 induces G1-phase arrest and mitochondrial membrane depolarization. KRAS G13D-IN-2 induces senescence through CDK6/TWIST1 inhibition. KRAS G13D-IN-2 inhibits tumor growth in murine models. KRAS G13D-IN-2 can be used for KRAS ^G13D-mutant colorectal cancer research .

HY-147891

Angiogenesis inhibitor 3	Apoptosis	Cancer
Angiogenesis inhibitor 3 (compound 8) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 3 inhibits the proliferation of HUVEC and HCT-15 cells, with IC₅₀ values of 1.00 and 0.71 μM. Angiogenesis inhibitor 3 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 3 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 3 inhibits the angiogenesis in zebrafish embryos .

HY-147890

Angiogenesis inhibitor 2	Apoptosis	Cancer
Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC₅₀ values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos .

HY-101055R

Kinetin riboside (Standard) N6-Furfuryladenosine (Standard)	Reference Standards Apoptosis	Cancer
Kinetin riboside (Standard) is the analytical standard of Kinetin riboside. This product is intended for research and analytical applications. Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC50 of 2.5 μM.

HY-144872

RJ-34	Drug Derivative	Cancer
RJ-34, an aristolactam analogue, exhibits potent antitumor activities against a broad array of cancer cell lines with GI₅₀ values in the subnanomolar range (GI₅₀ <0.1 nM for A431, MES-SA, MES-SA/DX5, HCT-15, and HCT-15/CLO2 cells) .

HY-101055S

Kinetin riboside-d5 N6-Furfuryladenosine-d₅	Isotope-Labeled Compounds Apoptosis	Cancer
Kinetin riboside-d₅ (N6-Furfuryladenosine-d₅) is the deuterium labeled Kinetin riboside (HY-101055). Kinetin riboside, a cytokinin analog, can induce apoptosis in cancer cells. It inhibits the proliferation of HCT-15 cells with an IC₅₀ of 2.5 μM .

HY-123898

Cepharadione B	Tyrosinase Endogenous Metabolite	Cancer
Cepharadione B (compound 22) is a natural compound isolated from the leaves of Piper sanctum. Cepharadione B is a tyrosinase inhibitor with an IC₅₀ value of 170 μM, and inhibits cell growth in A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cells .

HY-N9101

4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan	Others	Cancer
4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan is a lignans that can be isolated from the Viburnum foetidum. 4,4'-Dihydroxy-3,3',9-trimethoxy-9,9'-epoxylignan has cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cell line with IC₅₀s of 67.14, 67.38, 64.11 and 76.31 μg/mL, respectively .

HY-N3179

Norcepharadione B	Others	Others
Norcepharadione B is an alkaloid that can be isolated from Houttuynia cordata. Norcepharadione B exhibits moderate cytotoxicity against A-549, SK-OV-3, SK-MEL-2, XF-498 and HCT-15 cell line with ED₅₀s of 40, 26.4, 40, 14.2 and 38.2 μg/mL, respectively .

HY-155522

WES-1	Carbonic Anhydrase	Cancer
WES-1 (Compound 8g) is an inhibitor of carbonic anhydrase IX (K_i: 55.9 μM). WES-1 has broad spectrum anti-proliferative activity against the cancer cells, such as leukemia (K-562 and MOLT-4), non-small cell lung cancer (NCI–H460), colon cancer (HCT 116 and HCT-15) and melanoma (LOX IMVI) cell lines .

HY-159149

Antitumor agent-182	Reactive Oxygen Species (ROS) Apoptosis	Cancer
Antitumor agent-182 (Compound 12a) decreases mitochondrial membrane potential (MMP) and enhances ROS levels. Antitumor agent-182 arrests the cell cycle at G0/G1 phase, induces apoptosis in HeLa. Antitumor agent-182 inhibits the proliferation of HeLa, PC-3 and HCT-15 with IC₅₀s of 8.83, 10.07 and 7.84 μM, respectively .

HY-N15636

Coccinine (-)-Coccinine	Serotonin Transporter P-glycoprotein	Neurological Disease Cancer
Coccinine ((-)-Coccinine) is a weak inhibitor of SERT (IC₅₀: 196.3 μM; K_i: 106.8 μM) and P-gp (IC₅₀: 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases .

HY-N1614

1α-Hydroxytorilin	Others	Others
1 α-hydroxytorilin (compound 3) is a sesquiterpenoid. 1 α-hydroxytorilin can be isolated from Torilis japonica. 1α-hydroxytorilin has cytotoxicity against human A549, SK-OV-3, SK-MEL-2, and HCT15 tumor cells with ED50 values of 20.52, 18.24, 17.48, 42.54 μg/mL, respectively .

HY-N12349

Glucozaluzanin C	Others	Others
Glucozaluzanin C is a lignan isolated from the MeOH extract of the roots of Ainsliaea acerifolia (Compositae). Glucozaluzanin C has ED₅₀ value of 2.45 μg/mL, 1.37μg/mL, 0.40 μg/mL, 1.41 μg/mL, 1.43 μg/mL for A549 cells, SK-OV-3 cells, SK-MEL-2 cells, XF498 cells, HCT15 cells, respectively .

HY-N12589

8-epi-Helenalin	Others	Cancer
8-epi-Helenalin is a semitterpene lactone with anti-tumor activity that can be isolated from Inula britannicaL. var. chinensis (Rupr.) Reg. and the ED₅₀ values of 8-epi-Helenalin for HL-60, A549, MCF7, HCT-15, SK-OV-3 and Malme-3M are 12.2 μM, 53.8 μM, 9.1 μM, 8.7 μM, 18.7 μM and 8.3 μM, respectively. 8-epi-Helenalin can be used for anti-tumor studies .

HY-N11082

Isocucurbitacin D	Others	Cancer
Isocucurbitacin D is an antitumor agent .

HY-162714

C3N-Dbn-Trp2	P-glycoprotein	Cancer
C3N-Dbn-Trp2 is an inhibitor for ATP-binding cassette transporter ABCB1. C3N-Dbn-Trp2 inhibits the ABCB1-mediated Rhodamine 123 (HY-D0816) efflux in cells HEK293T and HCT-15 with IC₅₀ of 5.9 µM and 2.2 µM. C3N-Dbn-Trp2 inhibits the Doxorubicin (HY-15142A) efflux, enhances the cytotoxicity of Doxorubicin in ABCB1-expressing cells .

HY-144744

NF-κB-IN-3	NF-κB	Cancer
NF-κB-IN-3 (Compound 2) is a NF-κB inhibitor with an IC₅₀ of 0.70 µM. NF-κB-IN-3 can be used as an antitumor agent .

HY-100187

(Rac)-[6]-Gingerol (±)-[6]-Gingerol	Drug Isomer	Cancer
(Rac)-[6]-Gingerol is a natural product. (Rac)-[6]-Gingerol can be isolated from rhizomes of Z. officinale. (Rac)-[6]-Gingerol shows moderate anticancer activity against lung cancer, ovarian cancer, melanoma, and colon cancer .

HY-N17311

(22E,24R)-5α,6α-Epoxyergosta-8,22-diene-3β,7β-diol	Others	Cancer
(22E,24R)-5α,6α-Epoxyergosta-8,22-diene-3β,7β-diol (Compound 3) is an ergosterol. (22E,24R)-5α,6α-Epoxyergosta-8,22-diene-3β,7β-diol can be isolated from A. subjunquillea. (22E,24R)-5α,6α-Epoxyergosta-8,22-diene-3β,7β-diol can be used in the research of non-small cell lung cancer, ovarian cancer, melanoma, and colon cancer .

Cat. No.	Product Name	Target	Research Area