6,8-Diprenylorobol
Based on 1 Customer Validation
6,8-Diprenylorobol, a prenylated isoflavone, is a nature product that could be isolated from the leaves of Cudrania tricuspidata. 6,8-Diprenylorobol antiproliferative effect and induces apoptosis through activation of p53 and generation of ROS.
For research use only. We do not sell to patients.
- Purity: 98.40%
- CAS No.: 66777-70-6
- Formula: C25H26O6
- Molecular Weight:422.47
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| RAW264.7 | IC50 |
14.3 μM
Compound: 19
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Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
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[PMID: 31403786] |
6,8-Diprenylorobol (20-60 μM; 24-72 h) inhibits proliferation in LoVo and HCT15 cells[1].
6,8-Diprenylorobol (20-60 μM; 24 h) induces apoptosis and activates p53 and regulates MAPKs in LoVo and HCT15 cells[1].
6,8-Diprenylorobol (20-60 μM; 1 h) increases ROS level in LoVo and HCT15 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:LoVo and HCT15 cells
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Concentration:20, 40, and 60 μM
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Incubation Time:24, 48, and 72 hours
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Result:Inhibited the growth of LoVo and HCT15 cells in a dose- and dose-dependent manner.
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Cell Line:LoVo and HCT15 cells
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Concentration:20, 40, and 60 μM
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Incubation Time:24 hours
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Result:Induced apoptosis of LoVo and HCT15 cells in a dose- and time-dependent manner.
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Cell Line:LoVo and HCT15 cells
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Concentration:20, 40, and 60 μM
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Incubation Time:24, 48, and 72 hours
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Result:Decreased the expression of PARP and increased the expression of cleaved PARP.
Up-regulated Bax and Bim expressions and downregulated Bcl-2 expression.
Up-regulated cleaved caspase-3, -7, -8, and -9 expressions, and down-regulated procaspase-3, -7, -8, and -9 expressions.
Decreased the expression of phosphorylated Akt, ERK, JNK, and p38 and increased the expression of FOXO3, p53, p27, and p21.
Chemical Information
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CAS No. 66777-70-6
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Appearance Solid
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Molecular Weight 422.47
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Formula C25H26O6
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Color Off-white to light yellow
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SMILES
O=C1C(C2=CC=C(O)C(O)=C2)=COC3=C(C/C=C(C)\C)C(O)=C(C/C=C(C)\C)C(O)=C13
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
[1]. Choi YJ, et, al. 6,8-Diprenylorobol induces apoptosis in human colon cancer cells via activation of intracellular reactive oxygen species and p53. Environ Toxicol. 2021 May;36(5):914-925. [Content Brief]
[2]. Tuan Anh HL, et, al. Prenylated isoflavones from Cudrania tricuspidata inhibit NO production in RAW 264.7 macrophages and suppress HL-60 cells proliferation. J Asian Nat Prod Res. 2017 May;19(5):510-518. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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