Angiogenesis inhibitor 2
Angiogenesis inhibitor 2 (compound 72) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 2 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.93 and 0.21 μM. Angiogenesis inhibitor 2 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 2 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 2 inhibits the angiogenesis in zebrafish embryos.
For research use only. We do not sell to patients.
- CAS No.: 2151067-32-0
- Formula: C42H50N4O6S
- Molecular Weight:738.93
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
4.22 μM
Compound: 4c
|
Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human HEL cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 29133049] |
| K562 | IC50 |
3.19 μM
Compound: 4c
|
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human K562 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 29133049] |
| MDA-MB-231 | IC50 |
5.57 μM
Compound: 4c
|
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 29133049] |
| PC-3 | IC50 |
2.1 μM
Compound: 4c
|
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
Cytotoxicity against human PC3 cells assessed as reduction in cell viability after 48 hrs by MTT assay
|
[PMID: 29133049] |
Chemical Information
-
CAS No. 2151067-32-0
-
Molecular Weight 738.93
-
Formula C42H50N4O6S
-
SMILES
COC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=C(C=C(C(OC5=CC=C(C[C@@]6([H])C7=CC(O2)=C(C=C7CCN6C)OC)C=C5)=C4)OC)NC(NC(C)C)=S
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Angiogenesis inhibitor 2 Related Classifications
HY-147890 Related Classifications
Powered by Bioz