485-57-4
Chemical Structure
Coccinine
Synonym(s): (-)-Coccinine
- CAS No.: 485-57-4
- Formula:C17H19NO4
- Molecular Weight:301.34
InChIKey: MKYLOMHWHWEFCT-ZQDZILKHSA-N
SMILES: CO[C@@H]1C=C2[C@]3([H])C4=CC(OCO5)=C5C=C4C[N@]([C@@]2([H])C[C@@H]1O)C3
Biological Activity: Coccinine ((-)-Coccinine) is a weak inhibitor of SERT (IC50: 196.3 μM; Ki: 106.8 μM) and P-gp (IC50: 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases[1][2].
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Coccinine | Coccinine ((-)-Coccinine) is a weak inhibitor of SERT (IC50: 196.3 μM; Ki: 106.8 μM) and P-gp (IC50: 0.96 mM). Coccinine exhibits significant anti-tumor activity against various cancer cell lines, such as breast cancer (MCF7, Hs578T, MDA-MB-231), colon cancer (HCT-15), and lung cancer (A549). Coccinine can be used in the research of tumors and neurological diseases. | |||||||||||||||||||||
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- [1]. Masi M, et al. Alkaloids isolated from Haemanthus humilis Jacq., an indigenous South African Amaryllidaceae: Anticancer activity of coccinine and montanine. South African Journal of Botany, 2019, 126: 277-281.
- [2]. Stafford G I, et al. Serotonin transporter protein (SERT) and P-glycoprotein (P-gp) binding activity of montanine and coccinine from three species of Haemanthus L.(Amaryllidaceae). South African Journal of Botany, 2013, 88: 101-106.
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