256934-83-5
Chemical Structure
A-259745
Synonym(s): A-289099
- CAS No.: 256934-83-5
- Formula:C21H22N2O4
- Molecular Weight:366.41
IUPAC Name: 2-(1-methyl-1H-indol-5-yl)-5-(3,4,5-trimethoxyphenyl)-4,5-dihydrooxazole
InChIKey: VVXYHELHUZGLHK-UHFFFAOYSA-N
SMILES: CN1C=CC2=C1C=CC(C3=NCC(C4=CC(OC)=C(OC)C(OC)=C4)O3)=C2
Biological Activity: A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer[1].
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A-259745 | A-259745 is an orally active antimitotic agent that binds to the colchicine-binding site of tubulin. A-259745 exhibits potent in vitro cytotoxic activity against both multi-drug-resistant and non-multi-drug-resistant cancer cell lines, with ED50 values of 0.018 μM against HCT-15 and 0.028 μM against NCI-H460 cell lines. A-259745 inhibits tubulin polymerization, disrupts the dynamic equilibrium of the mitotic spindle, arrests dividing cells in metaphase, and subsequently induces apoptosis. A-259745 shows dose-dependent antitumor efficacy in murine tumor models. A-259745 can be used for the study of cancer. | |||||||||||||||||||||
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