2507759-39-7
Chemical Structure
Angiogenesis inhibitor 3
- CAS No.: 2507759-39-7
- Formula:C44H42BrN3O9
- Molecular Weight:836.72
IUPAC Name: (11S,31S)-35-bromo-16,36,54-trimethoxy-12,32-dimethyl-56-nitro-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane-37-yl benzoate
InChIKey: MLOAMUYYMSJIRP-HEVIKAOCSA-N
SMILES: O=C(C1=CC=CC=C1)OC2=C3C4=C(C(Br)=C2OC)CCN(C)[C@@]4([H])CC5=C(C=C(C(OC6=CC=C(C[C@@]7([H])C8=CC(O3)=C(C=C8CCN7C)OC)C=C6)=C5)OC)[N+]([O-])=O
Biological Activity: Angiogenesis inhibitor 3 (compound 8) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 3 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.00 and 0.71 μM. Angiogenesis inhibitor 3 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 3 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 3 inhibits the angiogenesis in zebrafish embryos[1].
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Angiogenesis inhibitor 3 | Angiogenesis inhibitor 3 (compound 8) is a potent angiogenesis inhibitor. Angiogenesis inhibitor 3 inhibits the proliferation of HUVEC and HCT-15 cells, with IC50 values of 1.00 and 0.71 μM. Angiogenesis inhibitor 3 induces the apoptosis of HUVEC and HCT-15 cells. Angiogenesis inhibitor 3 shows anticancer activity, and suppresses the invasion of cancer cells. Angiogenesis inhibitor 3 inhibits the angiogenesis in zebrafish embryos. | |||||||||||||||||||||
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