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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
29 Results for "
HL-1
" in MedChemExpress (MCE) Product Catalog:
Products (29)
29 Results for "HL-1" in MCE Product Catalog:
Cat. No.: HY-164055
CAS No.: 202828-10-2
Target:
Research Areas:
HL1 is a Schiff base ligand. HL1 exhibits chelation-enhanced fluorescence effect when forming complexes and can be used as a fluorescent probe for metal ions. HL1 can be used for the research of cancer [1].
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19 Publications Verification
Cat. No.: HY-N0279
CAS No.: 18956-16-6
Synonyms: Cardamomin; Alpinetin chalcone
5
5 Cited Publications
Cat. No.: HY-D1594
CAS No.: 217190-24-4
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Target:
Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals [1] [1] .
1
1 Cited Publications
Cat. No.: HY-P701099
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: ITLN1; Galactofuranose-Binding Lectin; Intelectin 1; Endothelial Lectin HL-1; ITLN; Intelectin-1; LFR; FLJ20022; Omentin; ITLN-1; HIntL; INTL; HL-1; Intelectin Variant; Intelectin 1 (Galactofuranose Binding); HL1; Intestinal Lactoferrin Receptor
1
Cat. No.: HY-152086
CAS No.: 1453028-33-5
Target:
Research Areas:
DRP1i27 is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury [1].
Cat. No.: HY-152086A
Purity: 98.63%
Target:
Research Areas:
DRP1i27 dihydrochloride is a potent inhibitor of human Drp1 (dynamin-related protein 1). DRP1i27 dihydrochloride binds to the GTPase site of Drp1, with hydrogen bonds to Gln34 and Asp218. DRP1i27 dihydrochloride targets Drp1-mediated mitochondrial fission in cell line models and protects against simulated ischemia-reperfusion injury [1].
Category:
Other Terpenoids Pinus nigra Arn. Pinaceae Terpenoids Plants
Cat. No.: HY-DY1076
CAS No.: 217190-24-4
Solvent and concentration: DMSO: 2 mM
Cat. No.: HY-145816
CAS No.: 2669785-77-5
Research Areas:
JPS016 is a class I histone deacetylase (HDAC) PROTAC inhibitor. JPS016 recruits the VHL E3 ligase (Ligands for E3 Ligase) to mediate the ubiquitination and proteasomal degradation of HDAC1, HDAC2 and HDAC3. JPS016 reduces the viability of colon cancer cells and induces Apoptosis. JPS016 activates the PINK1/Parkin mitochondrial Autophagy pathway, enhances cardiomyocyte viability, alleviates mitochondrial damage, and reduces mitochondrial ROS production in cells. JPS016 is applicable to research related to colon cancer and sepsis cardiomyopathy [1] .
Target:
Thiosemicarbazide is a vitamin B6 antagonist with anti-acne activity. Thiosemicarbazide is also a well-known source in the synthesis of heterocycles, and its derivatives have potential anticancer activity. Thiosemicarbazide (TSC: HL1) reacts with metal salts, urea (U), to prepare Co(II) and Cu(I) metal complexes. Thiosemicarbazide is also used in the fields of media communications and optical storage, and in the spectrophotometric detection of metals [1] [1] .
Cat. No.: HY-RS06982
Target:
Research Areas:
ITLN1 Human Pre-designed siRNA Set A contains three designed siRNAs for ITLN1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS01085
Target:
Research Areas:
ASGR1 Human Pre-designed siRNA Set A contains three designed siRNAs for ASGR1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS03850
Target:
Research Areas:
DNAH5 Human Pre-designed siRNA Set A contains three designed siRNAs for DNAH5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-178344
Target:
Research Areas:
Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure [1].
Cat. No.: HY-149779
CAS No.: 3012675-16-7
Target:
Research Areas:
RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca 2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca 2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias [1].
Cat. No.: HY-E70390
Synonyms: masp-2, c1 esterase, c1-esterase
Target:
Research Areas:
C1s Enzyme is a subunit of the complement C1 complex, which activates the complement as a serine protease. C1s Enzyme cleaves LRP5 and LRP6, and thus activates the Wnt/β-Catenin signaling pathway. C1s Enzyme promotes the macrophage M2 polarization and inhibits M1 polarization. C1s Enzyme enhances efferocytosis, exhibits anti-inflammatory activity [1].
Cat. No.: HY-P705990
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: ASGR1; ASGR1 Protein; Asialoglycoprotein Receptor 1; ASGP-R 1; CLEC4H1; ASGPR 1; C-Type Lectin Domain Family 4 Member H1; ASGPR1; Hepatic Lectin H1; ASGPR; HL-1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
