Multi-target kinase-IN-6
Multi-target kinase-IN-6 is a Multiple target kinase inhibitor. Multi-target kinase-IN-6 can inhibit cardiac RyR2- and NaV1.5-channels but stimulate SERCA2a pump activity. Multi-target kinase-IN-6 can be used for the research of cardiovascular disease, such as heart failure.
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- Fòrmula: C26H36BN3O3S
- Peso molecular:481.46
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
In Vitro
Multi-target kinase-IN-6 (Compound 12) (25 μM, 24 h) inhibits RyR2-mediated Ca2+ leakage in HEK-293 RyR2 R-CEPIA1er cells[1].
Multi-target kinase-IN-6 (1.1 μM, 2 h) activates sarcoplasmic reticulum Ca2+-ATPase 2a (SERCA2a) in HL-1 cardiomyocytes[1].
Multi-target kinase-IN-6 (2.3 nM, 10 mins) significantly enhances the ATPase activity of SERCA2a in sarcoplasmic reticulum microsomal vesicles isolated from adult mouse ventricles[1].
Multi-target kinase-IN-6 (10 μM, 30 mins) inhibits NaV1.5-mediated Na+ influx in CHO NaV1.5 Duo cells[1].
Multi-target kinase-IN-6 (10 μM, 24 h) causes no significant cell death in HL-1 cardiomyocytes[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 481.46
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Fòrmula C26H36BN3O3S
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SMILES
OC(C=C1/C=C/C[NH+](CCCCCCN2CCSC3=CC=C(C=C3C2)OC)[BH2-]C#N)=C(C=C1)O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Multi-target kinase-IN-6 Related Classifications
HY-178344 Related Classifications
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