3012675-16-7

RyR2 stabilizer-1 Chemical Structure
3012675-16-7

Chemical Structure

RyR2 stabilizer-1

  • CAS No.: 3012675-16-7
  • Formula:C28H46N2O3S
  • Molecular Weight:490.74

InChIKey: LSGDCGWYQCFSIJ-UHFFFAOYSA-N

SMILES: OC1(CCCCN(CCCCN2CC3=C(SCC2)C=CC(OC)=C3)CCCCC4(CC4)O)CC1

Biological Activity: RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias[1].

Cat. No. Product Name Purity Description Pricing
HY-149779 		RyR2 stabilizer-1 RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias.
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