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HPK1/GLK-IN-1

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-144093
    HPK1/GLK-IN-1

    		MAP4K Infection
    HPK1/GLK-IN-1 is a HPK1 and GLK inhibitor. HPK1/GLK-IN-1 (compound 38) potently inhibits GLK with an IC50 of  33 nM . HPK1-IN-26 can be used for the research of animal pathogen infection [1].
    HPK1/GLK-IN-1
  • HY-179338
    HPK1-IN-65

    		MAP4K HOXA Interleukin Related Cancer
    HPK1-IN-65 is a selective and orally active HPK1 inhibitor with an IC50 value of < 5 nM. HPK1-IN-65 inhibits HPK1 kinase activity and displays 1257-fold selectivity over the MAP4K kinase family member GLK. HPK1-IN-65 exhibits an IC50 of 92.3 nM for inhibiting pSLP76 phosphorylation. HPK1-IN-65 demonstrates an EC50 of 398 nM for stimulating IL-2 production. HPK1-IN-65 inhibits TCR-induced phosphorylation of SLP76 at Ser376 in a dose-dependent manner. HPK1-IN-65 can be further utilized for colorectal cancer research [1].
    HPK1-IN-65

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