2229042-24-2
2229042-24-2
Chemical Structure
HPK1/GLK-IN-1
- CAS 番号: 2229042-24-2
- Formula:C19H21N5OS
- Molecular Weight:367.47
IUPAC Name: N,N-dimethyl-1-(3-((methylamino)methyl)phenyl)methanamine dihydrochloride
InChIKey: HSEGDFMLRPWOHH-UHFFFAOYSA-N
SMILES: NC1=C(C=C(C2=CN=C(C3CCNCC3)S2)C=N1)OCC4=CC=NC=C4
Biological Activity: HPK1/GLK-IN-1 is a HPK1 and GLK inhibitor. HPK1/GLK-IN-1 (compound 38) potently inhibits GLK with an IC50 of 33 nM[2]. HPK1-IN-26 can be used for the research of animal pathogen infection[1].
| 製品番号 | 製品名 | 純度 | 製品説明 | Pricing | |||||||||||||||||||
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HPK1/GLK-IN-1 | 99.39% | HPK1/GLK-IN-1 is a HPK1 and GLK inhibitor. HPK1/GLK-IN-1 (compound 38) potently inhibits GLK with an IC50 of 33 nM. HPK1-IN-26 can be used for the research of animal pathogen infection. | ||||||||||||||||||||
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References
- [1]. Lin XY, et, al. Applications of hpk1 kinase inhibitor in preventing and/or treating animal pathogen infection. WO2021254118A1.
- [2]. May-Dracka TL, et al. Investigating small molecules to inhibit germinal center kinase-like kinase (GLK/MAP4K3) upstream of PKCθ phosphorylation: Potential therapy to modulate T cell dependent immunity. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1964-1971. [Content Brief]
Keywords
