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Isoforms Recommended:	IKK-β

Results for "

IKK-2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	IKK (25) Apoptosis (3) Interleukin Related (3) LRRK2 (3) MAPKAPK2 (MK2) (2) NF-κB (3) P-glycoprotein (3) PKD (3) Reference Standards (6) Small Interfering RNA (siRNA) (3) STAT (2) TNF Receptor (3)
By Research Areas:	Cancer (13) Cardiovascular Disease (2) Inflammation/Immunology (18)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Oligonucleotides

Targets Recommended: IKK

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10519

BMS-345541 30+ Cited Publications	IKK	Cancer
BMS-345541 is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-10074

TPCA-1 Maximum Cited Publications 41 Publications Verification	IKK STAT Apoptosis	Inflammation/Immunology Cancer
TPCA-1 is a potent and selective inhibitor of *IKK-2* with IC₅₀ of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-10518

BMS-345541 hydrochloride 30+ Cited Publications	IKK	Cancer
BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of *IKK* (IKK-2 IC₅₀=0.3 μM, *IKK-1* IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-10172

IMD-0354 20+ Cited Publications IKK2 Inhibitor V	IKK	Cancer
IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC₅₀ of 1.2 uM ^[2].

HY-13687

IKK 16 25+ Cited Publications	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 is an orally active IKK inhibitor. IKK 16 shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway ^[2] .

HY-13060

ACHP Hydrochloride 5+ Cited Publications IKK-2 Inhibitor VIII	IKK	Inflammation/Immunology
ACHP Hydrochloride (IKK-2 Inhibitor VIII) is a highly potent and selective *IKK-β* inhibitor with an IC₅₀ of 8.5 nM.

HY-13802

SC-514 5+ Cited Publications GK 01140	IKK	Cancer
SC-514 is a selective *IKK-2* inhibitor (IC₅₀=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

HY-131249

MK2-IN-3 4 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 is a potent and selective inhibitor of **MAPKAP-K2 (MK-2), with an IC₅₀** of 8.5 nM. MK2-IN-3 shows selectivity for MK-2 over MK-3, MK-5, ERK2, MNK1, p38a (IC₅₀s=0.21, 0.081, 3.44, 5.7, and >100 μM, respectively) and MSK1, MSK2, CDK2, JNK2, IKK2 (IC₅₀s>200 μM). MK2-IN-3 can reduce TNFα production in both U937 cells and in vivo .

HY-B0788A

LY2409881 trihydrochloride 4 Publications Verification	IKK Apoptosis	Cancer
LY2409881 trihydrochloride is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-13687A

IKK 16 hydrochloride 25+ Cited Publications	IKK LRRK2 P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Cardiovascular Disease Inflammation/Immunology
IKK 16 hydrochloride is an orally active *IKK* inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for *IKK2, IKK* complex, *IKK1, and LRRK 2, respectively. IKK* 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, *PKD2, and PKD3* with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway ^[2] .

HY-19362

AZD3264 2 Publications Verification	IKK	Inflammation/Immunology
AZD3264 is a selective IkB-kinase *IKK2* inhibitor.

HY-14180

PHA 408 1 Publications Verification	IKK	Inflammation/Immunology
PHA 408 (PHA-408) is a potent, selective and orally active IκB kinase-2 (IKK-2) inhibitor. PHA 408 is a powerful anti-inflammatory agent against lipopolysaccharide (LPS)- and cigarette smoke (CS)-mediated lung inflammation .

HY-14682

GSK319347A 1 Publications Verification	IKK	Inflammation/Immunology
GSK319347A is a dual inhibitor of TBK1 and IKKε with IC₅₀s of 93 nM and 469 nM, respectively. GSK319347A also inhibits *IKK2* with an IC₅₀ of 790 nM.

HY-112457

MK2-IN-3 hydrate 4 Publications Verification	MAPKAPK2 (MK2)	Inflammation/Immunology
MK2-IN-3 hydrate (compound 16) is an orally active, selective, and ATP-competitive **MAPKAP-K2 (MK-2) inhibitor with an IC₅₀** of 8.5 nM.MK2-IN-3 hydrate is exceptional selectivity against MK-3 (IC₅₀=0.21 μM), MK-5 (IC₅₀=0.081 μM), ERK2 (IC₅₀=3.44 μM), MNK1(IC₅₀=5.7 μM) as well as CDK2, JNK2, IKK2, MSK1, and MSK2 .

HY-112456

IKK2-IN-4	IKK	Inflammation/Immunology
IKK2-IN-4 (compound 4) is a potent *IKK-2* inhibitor, with an IC₅₀ of 25 nM. IKK2-IN-4 can inhibit the LPS-induced production of TNFα in PBMCs .

HY-B0788

LY2409881	IKK	Cancer
LY2409881 is a selective IκB kinase β (IKK2) inhibitor with an IC₅₀ of 30 nM.

HY-107591A

(Rac)-PF-184 hydrate	IKK	Inflammation/Immunology
(Rac)-PF-184 hydrate is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 hydrate has anti-inflammatory effects .

HY-111135

IKK2-IN-3	IKK	Inflammation/Immunology Cancer
IKK2-IN-3 is an *IKK2* inhibitor with an IC₅₀ value of 0.075 μM. IKK2-IN-3 can be used for the research of cancer, rheumatoid arthritis, chronic obstructive pulmonary disease (COPD) .

HY-10172R

IMD-0354 (Standard) IKK2 Inhibitor V (Standard)	Reference Standards IKK	Cancer
IMD-0354 (Standard) is the analytical standard of IMD-0354. This product is intended for research and analytical applications. IMD-0354 (IKK2 Inhibitor V) is a selective IKKβ inhibitor which inhibits NF-κB activity . IMD0354 inhibits TNF-α induced NF-κB transcription activity with an IC50 of 1.2 uM ^[2].

HY-107591B

PF-184	IKK	Inflammation/Immunology
PF-184 is a potent and selective *IKK-2* inhibitor (IC₅₀: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease .

HY-13687R

IKK 16 (Standard)	IKK LRRK2 Reference Standards P-glycoprotein PKD NF-κB TNF Receptor Interleukin Related	Inflammation/Immunology
IKK 16 (Standard) is the analytical standard of IKK 16. This product is intended for research and analytical applications. IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC₅₀s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC₅₀s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-κB pathway.

HY-112481

IKK2-IN-5		Inflammation/Immunology
IKK2-IN-5 is a selective *IKK-2* inhibitor with an IC₅₀ of 0.025 μM. IKK2-IN-5 inhibits the production of TNF-α in LPS (HY-D1056)-stimulated human peripheral blood mononuclear cells. IKK2-IN-5 exhibits extremely low cytotoxicity against human peripheral blood mononuclear cells .

HY-136392

IKK-IN-3	IKK	Inflammation/Immunology
IKK-IN-3 is a potent and selective IkappaB kinase 2 (IKK2 or IKKβ) inhibitor, with IC₅₀s of 19 and 400 nM for IKK2 and IKK1 (or IKKα), respectively .

HY-107591

(Rac)-PF-184	IKK	Inflammation/Immunology
(Rac)-PF-184 is a potent inhibitory factor-κB kinase 2 (IKK-2) inhibitor with an IC₅₀ of 37 nM. (Rac)-PF-184 has anti-inflammatory effects .

HY-13802R

SC-514 (Standard) GK 01140 (Standard)	IKK Reference Standards	Cancer
SC-514 (Standard) is the analytical standard of SC-514. This product is intended for research and analytical applications. SC-514 is a selective IKK-2 inhibitor (IC50=11.2 μM), which does not inhibit other IKK isoforms or other serine-threonine and tyrosine kinases.

HY-RS06659

Ikbkb Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ikbkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ikbkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ikbkb Mouse Pre-designed siRNA Set A Ikbkb Mouse Pre-designed siRNA Set A

HY-RS06660

Ikbkb Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Ikbkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ikbkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ikbkb Rat Pre-designed siRNA Set A Ikbkb Rat Pre-designed siRNA Set A

HY-RS06658

IKBKB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IKBKB Human Pre-designed siRNA Set A contains three designed siRNAs for IKBKB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IKBKB Human Pre-designed siRNA Set A IKBKB Human Pre-designed siRNA Set A

HY-10074R

TPCA-1 (Standard)	IKK Reference Standards STAT Apoptosis	Inflammation/Immunology Cancer
TPCA-1 (Standard) is the analytical standard of TPCA-1 (HY-10074). This product is intended for research and analytical applications. TPCA-1 is a potent and selective inhibitor of IKK-2 with IC50 of 17.9 nM. TPCA-1 is an effective inhibitor of STAT3 phosphorylation, DNA binding, and transactivation.

HY-10519R

BMS-345541 (Standard)	Reference Standards IKK	Cancer
BMS-345541 (Standard) is the analytical standard of BMS-345541 (HY-10519). This product is intended for research and analytical applications. BMS-345541 is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC₅₀=0.3 μM, IKK-1 IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

HY-10518R

BMS-345541 hydrochloride (Standard)	Reference Standards IKK	Cancer
BMS-345541 hydrochloride (Standard) is the analytical standard of BMS-345541 hydrochloride (HY-10518). This product is intended for research and analytical applications. BMS-345541 hydrochloride is a selective inhibitor of the catalytic subunits of IKK (IKK-2 IC₅₀=0.3 μM, IKK-1 IC₅₀=4 μM). BMS-345541 binds at an allosteric site of IKK.

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P701786

	IKKβ Protein, Human (sf9, GST) 1 Publications Verification IKBKβ; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB; Serine/threonine protein kinase IKBKB	Human	Sf9 insect cells
	IKKβ protein is a serine kinase that is critical in the NF-kappa-B signaling pathway and can respond to various stimuli such as cytokines or cellular stress. As part of the classical IKK complex, IKKβ activates NF-kappa-B through phosphorylation inhibitors, leading to its degradation and release of NF-kappa-B for gene transcription. IKKβ Protein, Human (sf9, GST) is the recombinant human-derived IKKβ protein, expressed by sf9 insect cells , with N-GST labeled tag.

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Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Mouse (2) Rat (3)
Application:	ICC/IF (2) WB (6) ELISA (2)
Isotype:	IgG (2) IgG1 (3)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (4) Recombinant (1)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85217

	IKK beta Antibody (YA4909) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB	Human
	IKK beta Antibody (YA4909) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P87500

	IKK beta Antibody (YA7184) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ELISA	Human
	IKK beta Antibody (YA7184) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P87500A

	IKK beta Antibody (YA7184)(PBS only) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ELISA	Human
	IKK beta Antibody (YA7184) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P85530

	IKK beta Antibody (YA5222) I kappa B kinase 2; I kappa B kinase beta; I-kappa-B kinase 2; I-kappa-B-kinase beta; IkBKB; IKK 2; IKK B; IKK beta; IKK-B; IKK-beta; IKK2; IKKB; IKKB_HUMAN; IMD15; Inhibitor of kappa light chain gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells; Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta; Inhibitor of kappa light polypeptide gene enhancer in B cells, kinase beta; Inhibitor of nuclear factor kappa B kinase beta subunit; Inhibitor of nuclear factor kappa B kinase subunit beta; Inhibitor of nuclear factor kappa-B kinase subunit beta; MGC131801; NFKBIKB; Nuclear factor NF kappa B inhibitor kinase beta; Nuclear factor NF-kappa-B inhibitor kinase beta; Nuclear factor of kappa light chain gene enhancer in B cells inhibitor.	WB	Human, Rat
	IKK beta Antibody (YA5222) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to IKK beta.

HY-P80719

	IKK beta Antibody (YA347) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody (YA347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK beta.

HY-P80719A

	IKK beta Antibody (YA347)(PBS only) IKBKB; IKKB; Inhibitor of nuclear factor kappa-B kinase subunit beta; I-kappa-B-kinase beta; IKK-B; IKK-beta; IkBKB; I-kappa-B kinase 2; IKK2; Nuclear factor NF-kappa-B inhibitor kinase beta; NFKBIKB	WB, ICC/IF	Human, Mouse, Rat
	IKK beta Antibody (YA347) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to IKK beta.

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Ikbkb Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Ikbkb Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ikbkb gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Ikbkb Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Ikbkb Rat Pre-designed siRNA Set A contains three designed siRNAs for Ikbkb gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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