354811-10-2
354811-10-2
Chemical Structure
IKK2-IN-4
- CAS No.: 354811-10-2
- Formula:C12H11N3O2S
- Molecular Weight:261.30
IUPAC Name: 5-phenyl-2-ureidothiophene-3-carboxamide
InChIKey: PSVUSJKZJQMCSP-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(N)=O)SC(C2=CC=CC=C2)=C1)N
Biological Activity: IKK2-IN-4 is an orally active and selective IKK-2 inhibitor (IC50 = 0.025 μM) that also inhibits JNK-1 (IC50 = 1.6 μM). IKK2-IN-4 blocks IκB phosphorylation and NF-κB activation, and inhibits JNK-1 kinase activity. IKK2-IN-4 inhibits TNF-α production in PBMCs. IKK2-IN-4 can be used for research on IKK-2-related diseases, such as autoimmune diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
IKK2-IN-4 | 98.51% | IKK2-IN-4 is an orally active and selective IKK-2 inhibitor (IC50 = 0.025 μM) that also inhibits JNK-1 (IC50 = 1.6 μM). IKK2-IN-4 blocks IκB phosphorylation and NF-κB activation, and inhibits JNK-1 kinase activity. IKK2-IN-4 inhibits TNF-α production in PBMCs. IKK2-IN-4 can be used for research on IKK-2-related diseases, such as autoimmune diseases. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
Structural Analogs
-
Similarity Score 0.84
HY-10074TPCA-1 -
Similarity Score 0.75
HY-112481IKK2-IN-5 -
Similarity Score 0.69
HY-139196ThioLox -
Similarity Score 0.61
HY-169736JNK-IN-21 -
Similarity Score 0.61
HY-115887R110 -
Similarity Score 0.60
![1-([1,1'-Biphenyl]-4-yl)urea Chemical Structure](//file.medchemexpress.com/product_pic/hy-w198426.gif)
HY-W1984261-([1,1'-Biphenyl]-4-yl)urea -
Similarity Score 0.58
![[1,1'-Biphenyl]-3,5-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w075049.gif)
HY-W075049[1,1'-Biphenyl]-3,5-dicarboxylic acid -
Similarity Score 0.58
![[1,1'-Biphenyl]-2,5-dicarboxylic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-w456498.gif)
HY-W456498[1,1'-Biphenyl]-2,5-dicarboxylic acid -
Similarity Score 0.58
HY-W045268Ethyl-2-amino-4-phenyl thiophene-3-carboxylate -
Explore the MedChemAI to find more analogs
![1-([1,1'-Biphenyl]-4-yl)urea Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w198426.gif)
![[1,1'-Biphenyl]-3,5-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w075049.gif)
![[1,1'-Biphenyl]-2,5-dicarboxylic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-w456498.gif)
