354811-10-2
354811-10-2
Chemical Structure
IKK2-IN-4
- CAS No.: 354811-10-2
- Formula:C12H11N3O2S
- Molecular Weight:261.30
IUPAC Name: 5-phenyl-2-ureidothiophene-3-carboxamide
InChIKey: PSVUSJKZJQMCSP-UHFFFAOYSA-N
SMILES: O=C(C1=C(NC(N)=O)SC(C2=CC=CC=C2)=C1)N
Biological Activity: IKK2-IN-4 is an orally active and selective IKK-2 inhibitor (IC50 = 0.025 μM) that also inhibits JNK-1 (IC50 = 1.6 μM). IKK2-IN-4 blocks IκB phosphorylation and NF-κB activation, and inhibits JNK-1 kinase activity. IKK2-IN-4 inhibits TNF-α production in PBMCs. IKK2-IN-4 can be used for research on IKK-2-related diseases, such as autoimmune diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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IKK2-IN-4 | 98.51% | IKK2-IN-4 is an orally active and selective IKK-2 inhibitor (IC50 = 0.025 μM) that also inhibits JNK-1 (IC50 = 1.6 μM). IKK2-IN-4 blocks IκB phosphorylation and NF-κB activation, and inhibits JNK-1 kinase activity. IKK2-IN-4 inhibits TNF-α production in PBMCs. IKK2-IN-4 can be used for research on IKK-2-related diseases, such as autoimmune diseases. | ||||||||||||||||||||
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