Search Result

Results for "

LATS

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Large Tumor Suppressor (LATS) (11) Amino Acid Derivatives (1) Amino acid Transporter (4) Apoptosis (5) Arp2/3 Complex (1) ASCT (3) Biochemical Assay Reagents (1) Cholinesterase (ChE) (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (2) Drug Derivative (1) E1/E2/E3 Enzyme (1) EAAT (2) Environmental Pollutants (1) FAP (1) Hippo (MST) (2) Isotope-Labeled Compounds (1) Olfactory Receptor (1) Piezo Channel (1) Prostaglandin Receptor (2) PROTAC Linkers (1) Reference Standards (2) Ser/Thr Kinase (2) Small Interfering RNA (siRNA) (12) YAP (10)
By Research Areas:	Cancer (23) Cardiovascular Disease (2) Endocrinology (2) Inflammation/Immunology (1) Neurological Disease (4)
Click Chemistry:	PROTAC Synthesis (1) Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (4) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (4) siRNAs (12)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Targets Recommended: Large Tumor Suppressor (LATS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-138489

TRULI Maximum Cited Publications 27 Publications Verification LATS-IN-1	Ser/Thr Kinase Large Tumor Suppressor (LATS)	Others
TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of *Lats1* and *Lats2* kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues .

HY-150042

TDI-011536 3 Publications Verification	Large Tumor Suppressor (LATS) YAP	Cardiovascular Disease Others
TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration .

HY-108540

BCH 10+ Cited Publications 2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1	Apoptosis	Cancer
BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .

HY-160769

NIBR-LTSi 1 Publications Verification	Large Tumor Suppressor (LATS) YAP	Others
NIBR-LTSi is an orally active and selective *LATS* kinase inhibitor. NIBR-LTSi can activate YAP signaling. NIBR-LTSi promotes stem cell proliferation, maintains stemness and blocks differentiation. NIBR-LTSi accelerates liver regeneration following extended hepatectomy in mice .

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Arp2/3 Complex	Cancer
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-W011391

GPNA hydrochloride 5+ Cited Publications	Apoptosis ASCT	Cancer
GPNA hydrochloride is a well known substrate of the enzyme γ-glutamyltransferase (GGT). GPNA hydrochloride is a specific glutamine (Gln) transporter ASCT2 inhibitor. GPNA hydrochloride also inhibit Na ⁺-dependent carriers, such as SNAT family (SNAT1/2/4/5), and the Na ⁺-independent leucine transporters LAT1/2. GPNA reversibly induces apoptosis in A549 cells .

HY-147082

GA-017 5+ Cited Publications	Large Tumor Suppressor (LATS) YAP	Cancer
GA-017 is a potent and selective *LATS1* and *LATS2* (large tumor suppressor kinase 1/2) inhibitor, with IC₅₀ values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids .

HY-120139

KMH-233 1 Publications Verification	Amino acid Transporter	Cancer
KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-147165

VT02956 1 Publications Verification	Ser/Thr Kinase Large Tumor Suppressor (LATS)	Cancer
VT02956 is a *LATS* inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-W087830

L-p-Boronophenylalanine L-BPA	Biochemical Assay Reagents	Cancer
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and *L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT)*. When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .

HY-139330

MGH-CP1 1 Publications Verification	Apoptosis	Cancer
MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC₅₀s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion .

HY-164254

Cardiomyocyte proliferation promoting agent-1 (E/Z)-GA-002	Large Tumor Suppressor (LATS) YAP	Cardiovascular Disease Inflammation/Immunology Cancer
Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for *LATS1* and *LATS2, with its IC₅₀* values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP .

HY-N8847

α-Ionone alpha-Ionone	Environmental Pollutants Hippo (MST) YAP Apoptosis Olfactory Receptor Large Tumor Suppressor (LATS)	Cancer
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the *LATS-YAP-TAZ* signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-176886

LATS-IN-2	Large Tumor Suppressor (LATS) YAP	Others
LATS-IN-2 is an efficiently acting *LATS* (large tumor suppressor kinase) inhibitor. LATS-IN-2 shows potent inhibitory activity against *LATS1* with an IC₅₀ value of 1.3 nM. LATS-IN-2 suppresses the phosphorylation of YAP by inhibiting *LATS* kinase activity. LATS-IN-2 increases the thickness of the epidermis in mice. LATS-IN-2 can be used for the study of ocular diseases such as limbal stem cell deficiency and corneal endothelial dysfunction .

HY-175247

DDO-4033	Large Tumor Suppressor (LATS) E1/E2/E3 Enzyme YAP	Cancer
DDO-4033 is a SPOP inhibitor (IC₅₀ = 16.9 μM, K_d = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research .

HY-175649

LATS1/2-IN-1	Large Tumor Suppressor (LATS) YAP	Cancer
LATS1/2-IN-1 is a potent and selective *LATS1* and *LATS2* inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against *LATS1* and *LATS2* with IC₅₀ values of 4.4 nM and 5.5 nM as determined via r ³³P functional assay. LATS1/2-IN-1 displays cellular IC₅₀ values of 136 nM for *LATS1* and 36.0 nM for *LATS2* as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing .

HY-N3999

Venuloside A ESK246	Others	Cancer
Venuloside A is a potent inhibitor of *LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀* of 8.12 μM .

HY-130504

Propargyl-PEG1-acid 1 Publications Verification	PROTAC Linkers	Cancer
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-164401

QBS10072S	EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker	Neurological Disease Cancer
QBS10072S is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a *LAT1*-targeting domain and a cytotoxic domain. QBS10072S exhibits inhibitory potency against LAT1-mediated substrate uptake (IC₅₀ = 21 μM) of approximately 50-fold higher than that against LAT2 (IC₅₀ = 1100 μM). QBS10072S enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S can be used for the research of glioblastoma and aggressive T-cell lymphoma .

HY-120139A

(R)-KMH-233	ASCT	Cancer
(R)-KMH-233 is the isomer of KMH-233 (HY-120139), and can be used as an experimental control. KMH-233, a potent, reversible and selective l-type amino acid transporter 1 (LAT1) inhibitor, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM) .

HY-108540R

BCH (Standard) 2-Amino-2-norbornanecarboxylic acid (Standard); LAT1-IN-1 (Standard)	Apoptosis Reference Standards	Cancer
BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis .

HY-147165A

VT02956 hydrochloride	YAP Large Tumor Suppressor (LATS)	Cancer
VT02956 is a *LATS* inhibitor (IC₅₀: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids . VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-RS07539

LATS2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LATS2 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LATS2 Human Pre-designed siRNA Set A LATS2 Human Pre-designed siRNA Set A

HY-RS23797

Lats1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats1 Rat Pre-designed siRNA Set A Lats1 Rat Pre-designed siRNA Set A

HY-RS07538

LATS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LATS1 Human Pre-designed siRNA Set A contains three designed siRNAs for LATS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LATS1 Human Pre-designed siRNA Set A LATS1 Human Pre-designed siRNA Set A

HY-RS18181

Lats2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats2 Mouse Pre-designed siRNA Set A Lats2 Mouse Pre-designed siRNA Set A

HY-RS24655

Lats2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lats2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats2 Rat Pre-designed siRNA Set A Lats2 Rat Pre-designed siRNA Set A

HY-RS07536

LAT Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LAT Human Pre-designed siRNA Set A contains three designed siRNAs for LAT gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LAT Human Pre-designed siRNA Set A LAT Human Pre-designed siRNA Set A

HY-RS16816

Lat Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat Mouse Pre-designed siRNA Set A Lat Mouse Pre-designed siRNA Set A

HY-RS07537

LAT2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LAT2 Human Pre-designed siRNA Set A contains three designed siRNAs for LAT2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LAT2 Human Pre-designed siRNA Set A LAT2 Human Pre-designed siRNA Set A

HY-RS21361

Lat2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat2 Mouse Pre-designed siRNA Set A Lat2 Mouse Pre-designed siRNA Set A

HY-129934S

Latanoprost ethyl amide-d4 Lat-NEt-d₄	Isotope-Labeled Compounds Prostaglandin Receptor	Endocrinology
Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

HY-129934

Latanoprost ethyl amide Lat-NEt	Prostaglandin Receptor	Endocrinology
Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides.

HY-N8847R

α-Ionone (Standard) alpha-Ionone (Standard)	Reference Standards Hippo (MST) YAP	Cancer
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-RS17343

Lats1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lats1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lats1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lats1 Mouse Pre-designed siRNA Set A Lats1 Mouse Pre-designed siRNA Set A

HY-183147A

LAT1-IN-2 hydrochloride	Amino acid Transporter	Cancer
LAT1-IN-2 hydrochloride is an orally active anticancer agent, as well as a *LAT1* substrate and tubulin-binding agent. LAT1-IN-2 hydrochloride relies on LAT1 for cellular uptake, disrupts microtubule formation by binding to the colchicine site of tubulin, and induces actin depolymerization to transform cells into a spherical shape. LAT1-IN-2 hydrochloride effectively inhibits tumor growth in xenograft mice. Compared with Etoposide (HY-13629), LAT1-IN-2 hydrochloride shows higher distribution in tumor tissues, lower distribution in major organs, and better tolerability. LAT1-IN-2 hydrochloride has been applied in studies related to esophageal cancer .

HY-164401A

QBS10072S dihydrochloride	EAAT DNA/RNA Synthesis DNA Alkylator/Crosslinker	Neurological Disease Cancer
QBS10072S dihydrochloride is a bifunctional chemotherapeutic agent that can cross the blood-brain barrier (BBB), comprising a *LAT1*-targeting domain and a cytotoxic domain. QBS10072S dihydrochloride exhibits inhibitory potency against LAT1-mediated substrate uptake (IC₅₀ = 21 μM) of approximately 50-fold higher than that against LAT2 (IC₅₀ = 1100 μM). QBS10072S dihydrochloride enters LAT1-expressing tumor cells via LAT1-mediated active transport, induces DNA interstrand crosslinking, and causes DNA damage and cell death. QBS10072S dihydrochloride can be used for the research of glioblastoma and aggressive T-cell lymphoma .

HY-RS23256

Lat Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat Rat Pre-designed siRNA Set A Lat Rat Pre-designed siRNA Set A

HY-RS27880

Lat2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lat2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Lat2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lat2 Rat Pre-designed siRNA Set A Lat2 Rat Pre-designed siRNA Set A

HY-183513

L-Ala-BPA	FAP	Cancer
L-Ala-BPA is a boron delivery agent. L-Ala-BPA is transported into tumor cells via PEPT1/2 and LAT-1 (SLC7A5) pathways and is rapidly cleaved systemically by endogenous proteases including FAP to yield L-BPA (HY-W087830). L-Ala-BPA shows antitumor activity and can be used for the research of Boron Neutron Capture Therapy (BNCT) .

HY-182254

AChE/BChE-IN-35	Cholinesterase (ChE)	Neurological Disease
AChE/BChE-IN-35, Tacrine (HY-111338) derivative, is a brain-penetrant dual AChE/BChE inhibitor with an Electric Eel AChE IC₅₀ of 123.66 nM, human AChE IC₅₀ of 122.34 nM, and equine BChE IC₅₀ of 488.00 nM. AChE/BChE-IN-35 undergoes LAT1-mediated active transport across cell membranes. AChE/BChE-IN-35 exhibits enhanced brain exposure with slower brain tissue elimination. AChE/BChE-IN-35 can be used for the research of alzheimer's disease .

HY-14889

Fluciclovine	ASCT Amino acid Transporter Amino Acid Derivatives	Cancer
Fluciclovine is an amino acid analogue that can enter cells by targeting the amino acid transporters on the cell surface (mainly ASCT2 and *LAT1*). After being labeled with ¹⁸F, ¹⁸F-fluciclovine can be used as an imaging agent for positron emission tomography (PET) for prostate diagnosis imaging .

HY-181743

Piezo1 agonist 2	Piezo Channel Amino acid Transporter Drug Derivative	Neurological Disease
Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes *LAT1*. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases .

Cat. No.	Product Name	Type

HY-W087830

L-p-Boronophenylalanine L-BPA	Biochemical Assay Reagents
L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and *L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT)*. When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .

L-p-Boronophenylalanine

L-BPA

Biochemical Assay Reagents

L-p-Boronophenylalanine is a boron-containing substrate for L-type amino acid transporters (L_AT1 and L_AT2). L-p-Boronophenylalanine enters tumor cells by competing with natural amino acids for LAT, selectively accumulating boron in cancer cells. L-p-Boronophenylalanine can be used in boron neutron capture therapy (BNCT). When boron-10 captures thermal neutrons, a nuclear reaction occurs, producing high-energy alpha particles and lithium nuclei, which kill cancer cells at close range with little damage to surrounding tissues. L-p-Boronophenylalanine can be used in cancer research, especially glioblastoma and anaplastic astrocytoma .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-16929

Latrunculin A 10+ Cited Publications LAT-A	Macrolide Antibiotics Animals Classification of Application Fields Antibiotics Marine natural products Other Diseases Sponge Disease Research Anticancer Disease Research Fields Source Classification	Arp2/3 Complex
Latrunculin A (LAT-A), found in the red sea sponge Latrunculia magnifica, is a G-actin polymerization inhibitor. Latrunculin A binds to actin monomers and inhibits polymerization of actin with K_ds of 0.1, 0.4, 4.7 μM and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin and G-actin, respectively. Latrunculin A has effective anti-metastatic properties for cancer research. Latrunculin A blocks cell migration .

HY-N8847

α-Ionone alpha-Ionone	Structural Classification Natural Products Asteraceae Sonchus erzincanicusV.A.Matthews Plants Source Classification	Environmental Pollutants Hippo (MST) YAP Apoptosis Olfactory Receptor Large Tumor Suppressor (LATS)
α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the *LATS-YAP-TAZ* signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

HY-N3999

Venuloside A ESK246	Other Monoterpenes Terpenoids Pittosporaceae Plants Pittosporum venulosum F.Muell. Source Classification	Others
Venuloside A is a potent inhibitor of *LAT3. Venuloside A inhibits the leucine uptake in LNCaP prostate cancer cells with an IC₅₀* of 8.12 μM .

HY-N8847R

α-Ionone (Standard) alpha-Ionone (Standard)	Asteraceae Sonchus erzincanicusV.A.Matthews Plants Source Classification	Reference Standards Hippo (MST) YAP
α-Ionone (Standard) is the analytical standard of α-Ionone. This product is intended for research and analytical applications. α-Ionone (alpha-Ionone) is an activator of the olfactory receptor OR10A6. α-Ionone induces apoptosis by activating OR10A6 and increasing the phosphorylation of the LATS-YAP-TAZ signaling axis in the Hippo pathway. α-Ionone can inhibit tumor formation both in vivo and in vitro .

Species:	Human (3)
Tag:	His (3) Strep (2) Myc (1) GST (2)
Source:	sf9 insect cells (1) Sf9 insect cells (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705846

	LATS2-MOB1A-1-MST2 Protein, Human (Active, sf9, His, GST, Strep) LATS2-MOB1A-1-MST2 complex	Human	sf9 insect cells

HY-P703258

	LATS1-MOB1A-1-MST2 Protein, Human (Active, sf9, His, GST, StrepⅡ) WARTS	Human	Sf9 insect cells

HY-P704000

	LATS1 Protein, Human (His, Myc) Large tumor suppressor homolog 1; WARTS protein kinase (h-warts); WARTS	Human	E. coli
	LATS1 Protein, Human (His, Myc) is the recombinant human-derived LATS1 protein, expressed by E. coli, with C-Myc & N-10*His tag.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Species
Source
Tag
Accession
Gene ID
Molecular Weight
Purity
Endotoxin Level
Biological Activity
Appearance
Formulation
Storage & Stability
Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-129934S

Latanoprost ethyl amide-d4

Latanoprost ethyl amide-d₄ (Lat-NEt-d₄) is deuterium labeled Latanoprost ethyl amide. Latanoprost ethyl amide (Lat-NEt) is a latanoprost analog in which the C-1 carboxyl group has been modified to an N-ethyl amide. Prostaglandin esters have been shown to have ocular hypotensive activity.1 Prostaglandin N-ethyl amides were recently introduced as alternative prostaglandin ocular hypotensive prodrugs. Although it has been claimed that prostaglandin ethyl amides are not converted to the free acids in vivo, studies in our laboratories have shown that bovine and human corneal tissue converts the N-ethyl amides of various prostaglandins to the free acids with a conversion rate of about 2.5 μg/g corneal tissue/hr. Lat-NEt would be expected to show the typical intraocular effects of Latanoprost free acid, but with the much slower hydrolysis pharmacokinetics of the prostaglandin N-amides .

Host:	Rabbit (2)
Reactivity:	Human (2) Rat (1) Mouse (2) Rabbit (1)
Application:	IHC-P (1) ICC/IF (2) IP (1) IHC-F (1) WB (2) ELISA (2)
Isotype:	IgG (2)
Conjugation:	Non-conjugated (2)
Clonality:	Polyclonal (1) Monoclonal (1)
Modification:	Phosphorylated (1) Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81210

	*phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody* 1 Publications Verification LATS1 +LATS2 (phospho T1079 + T1041); Serine/threonine protein kinase LATS2; KPM; Large tumor supressor, homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS, large tumor suppressor, homolog 2 (Drosophila); LATS1 +LATS2 (phospho T1079 + T1041); p-LATS1 +LATS2(Thr1079 +Thr1041); RGD1564085; Serine/threonine protein kinase LATS1; WARTS; WARTS protein kinase; wts; 4932411G09Rik; AV277261; AW208599; AW228608; FLJ13161; LATS1_HUMAN.	WB, ELISA, IHC-P, IHC-F, ICC/IF	Human, Mouse, Rabbit
	phospho-LATS1+LATS2 (Thr1079 +Thr1041) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to phospho-LATS1+LATS2 (Thr1079 +Thr1041).

HY-P86304

	LATS1 Antibody (YA5996) Serine/threonine-protein kinase LATS1; Large tumor suppressor homolog 1; WARTS protein kinase; h-warts;	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	LATS1 Antibody (YA5996) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to LATS1.

Compare Products


Products	In-stock - + Add to Cart
Cat. No.
Host
Reactivity
Application
Dilution Ratio
Molecular Weight
Conjugation
Clonality
Immunogen
Appearance
Isotype
Gene ID
SwissProt ID
Purity
Formulation
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name		Classification

HY-175247

DDO-4033		Alkynes
DDO-4033 is a SPOP inhibitor (IC₅₀ = 16.9 μM, K_d = 15.1 μM). DDO-4033 impairs the malignant migration, invasion, and proliferation of clear cell renal cell carcinoma (ccRCC) cell lines. DDO-4033 disrupts SPOP recruitment to its substrate LATS1, inhibits its polyubiquitination and subsequent degradation, and upregulates LATS1 expression. DDO-4033 has promising antitumor activity and is promising for renal cell carcinoma research .

HY-130504

Propargyl-PEG1-acid 1 Publications Verification		Alkynes PROTAC Synthesis
Propargyl-PEG1-acid is a PEG-based PROTAC linker can be used in the synthesis of BTK-CRBN PROTACs Ibrutinib(HY-10997)-based PROTAC 4 and PROTAC 5. PROTAC 5 causes the degradation of BTK and induces the degradation of CSK, LYN, and LAT2 at 10 μM . Propargyl-PEG1-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

LATS

Inhibitors & Agonists

Biochemical Assay Reagents

NaturalProducts

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Natural
Products