2351906-71-1
2351906-71-1
Chemical Structure
Cardiomyocyte proliferation promoting agent-1
Synonym(s): (E/Z)-GA-002
- CAS No.: 2351906-71-1
- Formula:C19H23N3O3
- Molecular Weight:341.40
InChIKey: RJHQUBJDRHLKEX-PGMHBOJBSA-N
SMILES: O=C(C(C)NC1=CC=CC=C1)N/N=C(CC)\C2=CC=C(C(C)=C2O)O
Biological Activity: Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Cardiomyocyte proliferation promoting agent-1 | 99.87% | Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP. | ||||||||||||||||||||
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