896657-58-2
Chemical Structure
MGH-CP1
- CAS No.: 896657-58-2
- Formula:C20H24N4OS
- Molecular Weight:368.50
IUPAC Name: 2-((4H-1,2,4-triazol-3-yl)thio)-N-(4-((3r,5r,7r)-adamantan-1-yl)phenyl)acetamide
InChIKey: UUKXOVBCMOZQNC-XLWGHNRJSA-N
SMILES: O=C(CSC1=NN=CN1)NC2=CC=C(C=C2)C3(C[C@H](C4)C5)C[C@H]5C[C@H]4C3
Biological Activity: MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion[1].
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MGH-CP1 | 99.56% | MGH-CP1 is a potent and orally active TEAD2 and TEAD4 auto-palmitoylation inhibitor with IC50s of 710 nM and 672 nM, respectively. MGH-CP1 can decrease the palmitoylation levels of endogenous or ectopically expressed TEAD proteins in cells. MGH-CP1 can suppress Myc expression, inhibit epithelial over-proliferation, and induce apoptosis when together with Lats1/2 deletion. | ||||||||||||||||||||
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Keywords
