20448-79-7
20448-79-7
Chemical Structure
BCH
Synonym(s): 2-Amino-2-norbornanecarboxylic acid; LAT1-IN-1
- CAS No.: 20448-79-7
- Formula:C8H13NO2
- Molecular Weight:155.20
IUPAC Name: 2-aminobicyclo[2.2.1]heptane-2-carboxylic acid
InChIKey: MPUVBVXDFRDIPT-UHFFFAOYSA-N
SMILES: O=C(C1(N)C(C2)CCC2C1)O
Biological Activity: BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis[1][2][3].
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BCH | 99.13% | BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. | ||||||||||||||||||||
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BCH (Standard) | 99.84% | BCH (Standard) is the analytical standard of BCH. This product is intended for research and analytical applications. BCH (2-Amino-2-norbornanecarboxylic acid) is a selective and competitive inhibitor of large neutral amino acid transporter 1 (LAT1) significantly inhibit cellular uptake of amino acids and mTOR phosphorylation, which induces the suppression of cancer growth and apoptosis. | ||||||||||||||||||||
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References
- [1]. Ohshima Y, et al. Efficacy of system l amino acid transporter 1 inhibition as a therapeutic target in esophageal squamous cell carcinoma. Cancer Sci. 2016 Oct;107(10):1499-1505. [Content Brief]
- [2]. Singh N, et al. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. Int J Mol Sci. 2018 Dec 21;20(1). [Content Brief]
- [3]. Wang Q, et al. L-type amino acid transport and cancer: targeting the mTORC1 pathway to inhibit neoplasia. Am J Cancer Res. 2015 Mar 15;5(4):1281-94. eCollection 2015. [Content Brief]
Keywords
