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LPL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	LPL Receptor (2) Apoptosis (2) CaMK (1) COX (2) Endogenous Metabolite (2) ERK (1) Isotope-Labeled Compounds (1) JNK (1) Lipase (2) LXR (1) NF-κB (1) NO Synthase (1) PCSK9 (1) Phosphodiesterase (PDE) (1) Piezo Channel (1) PPAR (2) Reference Standards (2) Small Interfering RNA (siRNA) (4) Stearoyl-CoA Desaturase (SCD) (1)
By Research Areas:	Cancer (7) Cardiovascular Disease (2) Inflammation/Immunology (3) Metabolic Disease (6)
Oligonucleotides:	Nucleoside Analogs (1) Rat Pre-designed siRNA Sets (1) Inosine (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (2) siRNAs (4)

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Targets Recommended: LPL Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P4153

Enlicitide chloride MK-0616 chloride	PCSK9	Cardiovascular Disease
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC₅₀ of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders .

HY-P2752

Lipoprotein lipase, Pseudomonas sp LPL	Endogenous Metabolite	Metabolic Disease Cancer
Lipoprotein lipase, Pseudomonas sp (LPL) is a multifunctional enzyme from adipose tissue, heart and skeletal muscle, islets and macrophages. Lipoprotein lipase promotes normal lipoprotein metabolism, delivery and utilization of tissue-specific substrates. Lipoprotein lipase catalyzes the rate-limiting step of lipids in blood circulation .

HY-N5015

Rosmanol 1 Publications Verification	COX	Inflammation/Immunology Cancer
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-128671

6-Thioinosine 6TI; 6-Mercaptopurine riboside	PPAR LXR JNK NO Synthase	Metabolic Disease
6-Thioinosine (6TI) is a purine antimetabolite and an anti-adipogenic agent. 6-Thioinosine reduces the mRNA levels of PPARγ and C/EBPα and downregulates the mRNA levels of PPARγ target genes (LPL, CD36, aP2, and LXRα). 6-Thioinosine exerts its anti-adipogenic effects by downregulating PPARγ through JNK-dependent iNOS upregulation. 6-Thioinosine can be used to study adipocyte dysfunction .

HY-117549

Ibrolipim NO-1886	Lipase	Cardiovascular Disease
Ibrolipim (NO-1886) is an orally active lipoprotein lipase (LPL)-promoting agent. Ibrolipim decreases plasma triglycerides, increases high-density lipoprotein cholesterol levels. Ibrolipim has renoprotective and hypolipidemic effects .

HY-116538

(10E,12Z)-Octadeca-10,12-dienoic acid 1 Publications Verification trans-10,cis-12 CLA2	Endogenous Metabolite PPAR NF-κB Stearoyl-CoA Desaturase (SCD) Lipase	Metabolic Disease Inflammation/Immunology Cancer
(10E,12Z)-Octadeca-10,12-dienoic acid (trans-10,cis-12 CLA2) is an orally active PPARα activator and inhibits adipocyte differentiation. (10E,12Z)-Octadeca-10,12-dienoic acid and its downstream metabolites have various antioxidant and antitumor activities. (10E,12Z)-Octadeca-10,12-dienoic acid can induce proinflammatory cytokines and chemokines, which would lead to decreased adipogenesis and insulin resistance in adipose tissue. (10E,12Z)-Octadeca-10,12-dienoic acid can affect many aspects of milk fat synthesis. (10E,12Z)-Octadeca-10,12-dienoic acid reduces expression of lipogenic enzymes and inhibits the desaturation of fatty acids. (10E,12Z)-Octadeca-10,12-dienoic acid can reduce lipoprotein lipase (LPL) activity in cultured 3T3-L1 adipocytes and enhance triacylglycerol release from these cells. (10E,12Z)-Octadeca-10,12-dienoic acid decreases the expression of hepatic stearoyl-CoA desatyrase mRNA in mice. (10E,12Z)-Octadeca-10,12-dienoic acid is associated with changes in mucosal NF-κB and Cyclin D1 protein levels in mice .

HY-165607S

MCB-22-174	Piezo Channel Isotope-Labeled Compounds ERK CaMK	Metabolic Disease
MCB-22-174 is a deuterated Piezo1 agonist, with an EC₅₀ value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca ²⁺ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) .

HY-101395A

W146 TFA 5 Publications Verification	LPL Receptor Apoptosis	Metabolic Disease Cancer
W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC₅₀ value of 398 nM.

HY-RS07772

LPL Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LPL Human Pre-designed siRNA Set A contains three designed siRNAs for LPL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LPL Human Pre-designed siRNA Set A LPL Human Pre-designed siRNA Set A

HY-RS23635

Lpl Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lpl Rat Pre-designed siRNA Set A contains three designed siRNAs for Lpl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lpl Rat Pre-designed siRNA Set A Lpl Rat Pre-designed siRNA Set A

HY-RS07563

LCP1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
LCP1 Human Pre-designed siRNA Set A contains three designed siRNAs for LCP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

LCP1 Human Pre-designed siRNA Set A LCP1 Human Pre-designed siRNA Set A

HY-N5015R

Rosmanol (Standard)	Reference Standards COX	Inflammation/Immunology Cancer
Rosmanol (Standard) is the analytical standard of Rosmanol. This product is intended for research and analytical applications. Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-RS17184

Lpl Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Lpl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lpl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Lpl Mouse Pre-designed siRNA Set A Lpl Mouse Pre-designed siRNA Set A

HY-101395AR

W146 TFA (Standard)	LPL Receptor Reference Standards Apoptosis	Metabolic Disease Cancer
W146 (TFA) (Standard) is the analytical standard of W146 (TFA) (HY-101395A). This product is intended for research and analytical applications. W146 TFA is a selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1) with an EC50 value of 398 nM.

HY-119601

GRI918013	Phosphodiesterase (PDE)	Cancer
GRI918013 (compound 1) is a selective and competitive autotaxin (ATX/NPP2) inhibitor with anti-invasive and anti-metastatic activity. GRI918013 competitively binds to ATX, blocking lipid substrates such as lysophosphatidylcholine (LPC) from entering the ATX active site, thereby inhibiting ATX-mediated hydrolysis of LPC to lysophosphatidic acid (LPA), and consequently inhibiting ATX-LPA axis-related tumor cell invasion and metastasis. GRI918013 inhibits ATX-mediated hydrolysis of the LPL substrate FS-3 (IC₅₀=31.42 nM, K_i=12.98 nM). GRI918013 can be used in research on cancer invasion and metastasis, such as melanoma, and can also serve as a tool compound for ATX-LPA axis-related diseases such as fibrotic diseases, neuropathic pain, and cholestatic pruritus .

Cat. No.	Product Name	Target	Research Area

HY-P4153

Enlicitide chloride MK-0616 chloride	PCSK9	Cardiovascular Disease
Enlicitide chloride is an orally active inhibitor for PCSK9 that blocks the interaction between LPL receptor and PSCK9, with an IC₅₀ of 2.5 nM. Enlicitide chloride can be used in the study of cardiovascular diseases such as atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome or related cardiovascular and cardiometabolic disorders .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N5015

Rosmanol 1 Publications Verification	Classification of Application Fields Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	COX
Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

HY-N5015R

Rosmanol (Standard)	Paramacrolobium coeruleum (Taub.) J.Léonard Labiatae Phenols Polyphenols Plants Source Classification	Reference Standards COX
Rosmanol (Standard) is the analytical standard of Rosmanol. This product is intended for research and analytical applications. Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect.

Species:	Human (2)
Tag:	His (2)
Source:	P. pastoris (1) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71750

	LCP1 Protein, Human (P.pastoris, His) CP64; L plastin; L-plastin; Larval cuticle protein 1; LC64P; LCP-1; LCP1; LPL; LPLastin; Lymphocyte cytosolic protein 1; Plastin 2; Plastin-2; PLS2; PLSL_HUMAN	Human	P. pastoris
	LCP1 Protein, an actin-binding regulator, plays a crucial role in T-cell activation, responding to costimulation signals through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69 and interacts with AIF1 and actin. LCP1's involvement in immune responses and T-cell activation underscores its significance in cellular processes. LCP1 Protein, Human (P.pastoris, His) is the recombinant human-derived LCP1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P70221

	Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His) rHuAcyl-protein thioesterase 2/LYPLA2, His; Acyl-Protein Thioesterase 2; APT-2; Lysophospholipase II; LPL-II; LysoPLA II; LYPLA2; APT2	Human	E. coli
	Acyl-protein thioesterase 2/LYPLA2 Protein, Human (His) a protein palmitoyl thioesterase, is a cytosolic enzyme that catalyze depalmitoylation of membrane-anchored, growth-associated protein-43 (GAP-43).

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Cat. No.	Product Name	Chemical Structure

HY-165607S

MCB-22-174
MCB-22-174 is a deuterated Piezo1 agonist, with an EC₅₀ value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca ²⁺ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) .

MCB-22-174

MCB-22-174 is a deuterated Piezo1 agonist, with an EC₅₀ value of 6.28 μM. MCB-22-174 remarkably activates the CaMKII/ERK signaling pathway and initiates Ca ²⁺ influx in rMSCs. MCB-22-174 significantly decreases the expression of chondrogenesis markers (Comp, Acan) and adipogenesis markers (Lpl, Fabp4) in MSCs. MCB-22-174 can effectively improve bone quality in hind-limb unloading (HU) model rats. MCB-22-174 can be used for the study of disuse osteoporosis (OP) .

Host:	Rabbit (5)
Reactivity:	Human (5) Rat (3) Mouse (3)
Application:	IHC-P (4) ICC/IF (3) IF-Tissue (1) IHC-F (1) WB (5) FC (1)
Isotype:	IgG (5)
Conjugation:	Non-conjugated (5)
Clonality:	Monoclonal (4) Recombinant (4)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85262

	Lipoprotein Lipase Antibody (YA4954) LPL; LIPD; Lipoprotein lipase; LPL	WB, IHC-P, IHC-F, IF-Tissue	Human
	Lipoprotein Lipase Antibody (YA4954) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to Lipoprotein Lipase.

HY-P81831

	Lipoprotein Lipase Antibody (YA1576) LPL; LIPD; Lipoprotein lipase; LPL	WB, IHC-P	Human
	Lipoprotein Lipase Antibody (YA1576) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lipoprotein Lipase.

HY-P82197

	Plastin L Antibody (YA1942) CP64; L plastin; LC64P; LCP1; LPL; LPLastin; Plastin 2; PLS2	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Plastin L Antibody (YA1942) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Plastin L.

HY-P82452

	Lysophospholipase 1 Antibody (YA2197) APT1; hAPT1; LPL1; LYPLA1; Lysophospholipase 1; LYSOPLA; LysoPLA I	WB, ICC/IF, FC	Human, Mouse, Rat
	Lysophospholipase 1 Antibody (YA2197) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Lysophospholipase 1.

HY-P810677

	Lysophospholipase 1 Antibody (YA9935) APT1; hAPT1; LPL1; LYPLA1; Lysophospholipase 1; LYSOPLA; LysoPLA I	WB, ICC/IF, IHC-P	Human, Mouse, Rat
	Lysophospholipase 1 Antibody (YA9935) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Lysophospholipase 1.