2 Results for "

Licoflavone C

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Licoflavone C" in MCE Product Catalog:

1
Licoflavone C
Licoflavone C
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Cat. No.: HY-N4183
CAS No.: 72357-31-4
Category:  

Flavonoids Leguminosae Flavones Phenols Polyphenols Plants Disease Research Fields Glycyrrhiza uralensis Fisch. Cancer

Target:  

Apoptosis Caspase Estrogen Receptor/ERR

Licoflavone C is a broad-spectrum antiviral inhibitor with estrogen-like properties. Licoflavone C binds to viral endonuclease (CEN) and inhibits the replication of various bunyaviruses including severe fever with thrombocytopenia syndrome virus (SFTSV) and lymphocytic choriomeningitis virus in a non-substrate competitive manner. The IC50 values of Licoflavone C against SFTSV CEN and SFTSV CEN are 35.5 μM and 135.8 μM, respectively, and its Kd value against SFTSV CEN is 9.53 μM. After viral entry into cells, Licoflavone C reduces viral loads in mouse tissues in a dose-dependent manner, and exhibits extremely low cytotoxicity and genotoxicity. Licoflavone C induces apoptosis by increasing caspase 3/7 activity, blocks the cell cycle, and alleviates chemotherapy-induced chromosomal damage. Licoflavone C is applicable to the research on severe fever with thrombocytopenia syndrome and related viral infection mechanisms .
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Licoflavone B
Licoflavone B
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Cat. No.: HY-N4184
CAS No.: 91433-17-9
Category:  

Glycyrrhiza inflata Batal. Flavones Plants Infection Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Parasite Influenza Virus ATP Synthase c-Myc p38 MAPK Apoptosis

Licoflavone B is an orally active flavonoid, with IC50 values of 23.78 μM and 31.5 μM against SmATPase and SmADPase of Schistosoma mansoni, respectively. Licoflavone B selectively targets viral RdRp, inhibits viral replication, and reduces the expression levels of viral NP and PB2. Licoflavone B inhibits c-Myc expression and suppresses cancer cell proliferation. Licoflavone B disrupts the tegument of worms, reduces egg production, and induces the death of adult Schistosoma mansoni. Licoflavone B blocks the activation of the MAPK pathway, maintains colonic barrier integrity, inhibits colonic cell apoptosis, and reshapes the gut microbiota. Licoflavone B can be used in research related to influenza, multiple myeloma, schistosomiasis, and ulcerative colitis .
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