Search Result
Results for "
Lipid-1
" in MedChemExpress (MCE) Product Catalog:
12
Biochemical Assay Reagents
7
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-113378
-
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β-Hydroxybutyric acid
|
Endogenous Metabolite
|
Metabolic Disease
|
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3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .
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-
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- HY-112754A
-
DOTAP chloride
Maximum Cited Publications
14 Publications Verification
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
Liposome
|
Cancer
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
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- HY-W010452
-
|
β-Hydroxybutyric acid sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
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- HY-D0213
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-
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- HY-W145667
-
-
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- HY-W583868
-
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1,2-POPE; 16:0-18:1 PE
|
Liposome
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Others
|
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines [1] .
|
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-
- HY-156630
-
|
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Liposome
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Others
|
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
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- HY-B1513
-
|
|
Environmental Pollutants
SARS-CoV
Microtubule/Tubulin
|
Infection
Metabolic Disease
Cancer
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α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .
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- HY-158790
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Ferroptosis
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Cancer
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(R)-HTS-3 is an lysophosphatidylcholine acyltransferase 3 (LPCAT3) inhibitor, with an IC50 of 0.09 μM. (R)-HTS-3 suppresses the C20:4 content of PE, PC, and PS, while promoting a correspondingelevation in C22:4 phospholipids and a paradoxical increase in C20:4 phosphatidylinositol (PI) lipids .
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- HY-77490
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Endogenous Metabolite
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Metabolic Disease
|
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(R)-(-)-1,3-Butanediol is the R-enantiomer of 1,3-Butanediol (HY-77490A). (R)-(-)-1,3-Butanediol exhibits anti-diabetic property in rats. (R)-(-)-1,3-Butanediol can be used as flavoring and fragrance agents. (R)-(-)-1,3-Butanediol is used to regulate the metabolism of carbohydrate and lipid. .
|
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- HY-W010452S1
-
|
β-Hydroxybutyric acid-13C4 sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
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3-Hydroxybutyric acid- 13C4 sodium is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
|
-
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- HY-113378S
-
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β-Hydroxybutyric acid-d4 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
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3-Hydroxybutyric acid-d4 (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .
|
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- HY-112768
-
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Liposome
|
Others
|
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PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20 [1].
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- HY-W015780
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|
|
Environmental Pollutants
Endogenous Metabolite
|
Metabolic Disease
|
|
1,4-Dimethoxybenzene is an endogenous metabolite. 1,4-Dimethoxybenzene has an anti-anxiety effect, increasing atherogenic index (AI) levels in rabbits and inducing sedentary behavior. Sedentary behavior may increase blood cholesterol levels and disrupt blood lipids .
1,4-Dimethoxybenzene considers to be not clastogenic in the in vivo micronucleus test .
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- HY-112754AGL
-
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1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
|
Liposome
|
Others
|
|
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
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-
-
- HY-153136
-
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Liposome
|
Others
|
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LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids [1] .
|
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- HY-W010452R
-
|
β-Hydroxybutyric acid sodium (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
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- HY-B0589C
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|
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Cytochrome P450
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Metabolic Disease
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(3S,5S)-Atorvastatin is a inactive enantiomer of Atorvastatin. (3S,5S)-Atorvastatin can activate pregnane X receptor (PXR). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
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- HY-150116
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Liposome
|
Others
|
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Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
|
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- HY-113378R
-
|
β-Hydroxybutyric acid (Standard)
|
Reference Standards
Endogenous Metabolite
|
Metabolic Disease
|
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3-Hydroxybutyric acid (Standard) is the analytical standard of 3-Hydroxybutyric acid. This product is intended for research and analytical applications. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids[1].
|
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- HY-135380
-
|
|
Drug Intermediate
|
Cardiovascular Disease
|
|
Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
|
-
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- HY-156630A
-
|
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Liposome
|
Others
|
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
|
-
-
- HY-W725309
-
|
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate sodium
|
Biochemical Assay Reagents
|
Others
|
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18:0-18:1 PA (1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate) sodium is an anionic lipid .
|
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- HY-135377
-
|
(2E)-2,3-Dehydroxy Atorvastatin
|
Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
|
Atorvastatin 3-Deoxyhept-2E-Enoic Acid ((2E)-2,3-Dehydroxy Atorvastatin) is an impurity of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
|
-
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- HY-W015851S
-
|
3-Hydroxybutyric acid-13C sodium
|
Isotope-Labeled Compounds
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutanoic acid-13C- 13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
|
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- HY-N15799
-
-
-
- HY-133878
-
-
-
- HY-135381
-
|
|
Drug Metabolite
|
Cardiovascular Disease
|
|
3-Oxo Atorvastatin is an impurity of 3-Oxo Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
|
-
-
- HY-W010452S2
-
|
β-Hydroxybutyric acid-13C2 sodium
|
Endogenous Metabolite
|
Metabolic Disease
|
|
3-Hydroxybutyric acid- 13C2 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
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- HY-125818B
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Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate
|
DNA/RNA Synthesis
|
Metabolic Disease
|
|
Cytidine-5'-triphosphate sodium hydrate (Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate) is the sodium hydrate form of Cytidine-5'-triphosphate (HY-125818). Cytidine-5'-triphosphate sodium hydrate is a nucleoside triphosphate, that is invovled in biosynthesis of DNA, RNA and lipid .
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- HY-139231
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-
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- HY-136346
-
|
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Drug Metabolite
|
Cardiovascular Disease
|
|
2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
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- HY-126852
-
|
P-Hydroxyatorvastatin lactone; 4-ATL
|
Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
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4-Hydroxy Atorvastatin lactone is a metabolite of Atorvastatin (HY-B0589). Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
-
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- HY-135379
-
|
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Drug Metabolite
|
Cardiovascular Disease
|
|
Atorvastatin acetonide is an impurity of Atorvastatin, and extracted from patent WO2011131605A1, Compound 4. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
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- HY-W341713
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Drug Intermediate
|
Others
|
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Hepta-O-acetyl-α-D-lactosyl bromide (Compound 4) is a brominated lactoside. Hepta-O-acetyl-α-D-lactosyl bromide is a synthetic substrate for perfluoroalkyl-labeled lactose lipids .
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- HY-135375
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Drug Metabolite
|
Metabolic Disease
Inflammation/Immunology
|
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O-Methyl Atorvastatin (hemicalcium) is an impurity of Atorvastatin. Atorvastatin is an orally active 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, has the ability to effectively decrease blood lipids .
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- HY-W338792
-
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1-Decanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine
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Endogenous Metabolite
|
Others
|
|
1-Decanoyl-sn-glycero-3-phosphocholine (1-Decanoyl-2-hydroxy-sn-glycero-3-phosphatidylcholine) is a lipidic compound that can be found in sperm membrane lipids .
|
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- HY-136346S
-
|
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Drug Metabolite
|
Cardiovascular Disease
|
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Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
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- HY-135380R
-
|
|
Drug Intermediate
Reference Standards
|
Cardiovascular Disease
|
|
Atorvastatin acetonide tert-butyl ester (Standard) is the analytical standard of Atorvastatin acetonide tert-butyl ester. This product is intended for research and analytical applications. Atorvastatin acetonide tert-butyl ester is a useful pharmaceutical intermediate in the preparation of Atorvastatin salts. Atorvastatin is an orally active HMG-CoA reductase inhibitor and has the ability to effectively decrease blood lipids .
|
-
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- HY-147018
-
|
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Liposome
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Others
|
|
1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate is a PEG lipid. 1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate can be used for researching drug delivery [1].
|
-
![1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate](//file.medchemexpress.com/product_pic/hy-147018.gif)
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- HY-165427
-
|
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Liposome
|
Cancer
|
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Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems [1].
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-
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- HY-N15795
-
-
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- HY-180651
-
-
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- HY-N15787
-
-
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- HY-N15769
-
-
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- HY-179548
-
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Drug Derivative
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Others
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Photoclick palmitic acid is a derivative of the long-chain saturated fatty acid palmitic acid (HY-N0830). The photoclick-type long-chain saturated fatty acid has been used as a probe for studying protein lipidation .
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- HY-112754AS
-
|
|
Isotope-Labeled Compounds
Liposome
|
Cancer
|
|
DOTAP-d9 chloride is the deuterium labeled DOTAP chloride (HY-112754A). DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
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- HY-W583868S
-
|
1,2-POPE-d62; 16:0-18:1 PE-d62
|
Isotope-Labeled Compounds
|
Others
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62 (1,2-POPE-d62) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines [1] .
|
-
| Cat. No. |
Product Name |
Type |
-
- HY-112754AGL
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
|
Fluorescent Dyes
|
|
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
|
| Cat. No. |
Product Name |
Type |
-
- HY-112754A
-
DOTAP chloride
Maximum Cited Publications
14 Publications Verification
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
Biochemical Assay Reagents
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
- HY-W145667
-
Mannan
1 Publications Verification
|
Biochemical Assay Reagents
|
|
Mannan is an orally active polysaccharide compound that binds to the mannose receptor (MR). Mannan promotes bacterial uptake and endosomal degradation by binding to MR, thereby enhancing the production of IL-12 in immune cells. Mannan enhances ROS production. Mannan modulates immunity, inhibits Aflatoxin B1 (HY-N6615)-induced toxicity, and reduces lipid .
|
-
- HY-W583868
-
|
1,2-POPE; 16:0-18:1 PE
|
Biochemical Assay Reagents
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines [1] .
|
-
- HY-156630
-
|
|
Biochemical Assay Reagents
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
|
-
- HY-112768
-
|
|
Biochemical Assay Reagents
|
|
PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20 [1].
|
-
- HY-112754AGL
-
|
1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
|
Biochemical Assay Reagents
|
|
DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
|
-
- HY-153136
-
|
|
Biochemical Assay Reagents
|
|
LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids [1] .
|
-
- HY-150116
-
-
- HY-156630A
-
|
|
Biochemical Assay Reagents
|
|
Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
|
-
- HY-W725309
-
|
1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate sodium
|
Biochemical Assay Reagents
|
|
18:0-18:1 PA (1-Stearoyl-2-oleoyl-sn-glycero-3-phosphate) sodium is an anionic lipid .
|
-
- HY-125818B
-
|
Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate
|
Biochemical Assay Reagents
|
|
Cytidine-5'-triphosphate sodium hydrate (Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate) is the sodium hydrate form of Cytidine-5'-triphosphate (HY-125818). Cytidine-5'-triphosphate sodium hydrate is a nucleoside triphosphate, that is invovled in biosynthesis of DNA, RNA and lipid .
|
-
- HY-147018
-
|
|
Biochemical Assay Reagents
|
|
1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate is a PEG lipid. 1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate can be used for researching drug delivery [1].
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W010452S1
-
|
|
|
3-Hydroxybutyric acid- 13C4 sodium is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
|
-
-
- HY-113378S
-
|
|
|
3-Hydroxybutyric acid-d4 (sodium) is the deuterium labeled 3-Hydroxybutyric acid. 3-Hydroxybutyric acid (β-Hydroxybutyric acid) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid can modulate the properties of membrane lipids .
|
-
-
- HY-W015851S
-
|
|
|
3-Hydroxybutanoic acid-13C- 13C (sodium) is the 13C labeled 3-Hydroxybutanoic acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium (β-Hydroxybutyric acid sodium) is a metabolite that is elevated in type I diabetes. 3-Hydroxybutyric acid sodium can modulate the properties of membrane lipids .
|
-
-
- HY-W010452S2
-
|
|
|
3-Hydroxybutyric acid- 13C2 (sodium) is the 13C labeled 3-Hydroxybutyric acid sodium (HY-W010452). 3-Hydroxybutyric acid sodium is a metabolite that is elevated in type I diabetes, and can modulate the properties of membrane lipids .
|
-
-
- HY-136346S
-
|
|
|
Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids .
|
-
-
- HY-112754AS
-
|
|
|
DOTAP-d9 chloride is the deuterium labeled DOTAP chloride (HY-112754A). DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
-
- HY-W583868S
-
|
|
|
1-Palmitoyl-2-oleoyl-sn-glycero-3-PE-d62 (1,2-POPE-d62) is the deuterium labeled 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines [1] .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-112754A
-
DOTAP chloride
Maximum Cited Publications
14 Publications Verification
1,2-Dioleoyl-3-trimethylammonium-propane chloride
|
|
Cationic Lipids
|
|
DOTAP chloride is a useful and effective cationic lipid for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) with out the use of helper lipid .
|
-
- HY-W583868
-
|
1,2-POPE; 16:0-18:1 PE
|
|
Phospholipids
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1-Palmitoyl-2-oleoyl-sn-glycero-3-PE (1,2-POPE; 16:0-18:1 PE) is a phosphatidylethanolamine (PE) lipid. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can induce lipid bilayer to form a hexagonal phase (HII) structure in an acidic environment and promote membrane fusion. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can enhance the endosomal escape ability of lipid nanoparticles (LNPs) and improve the cellular delivery efficiency of nucleic acid drugs such as mRNA. 1-Palmitoyl-2-oleoyl-sn-glycero-3-PE can be used for LNP carrier targeting of gene therapy and mRNA vaccines [1] .
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- HY-156630
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Cationic Lipids
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
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- HY-B1513
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Others
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α-Cyclodextrin (α-CD) is a soluble fiber derived from corn. α-Cyclodextrin can deplete sphingolipids and phospholipids from cell membranes. α-Cyclodextrin interacts with tubulin. α-Cyclodextrin improves defenses against SARS-CoV-2 infection. α-Cyclodextrin enhances the anticancer efficacy of Crcumin (HY-N0005) against breast, lung and cervical cancer. α-Cyclodextrin has beneficial effects on body weight and blood lipids .
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- HY-112768
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Pegylated Lipids
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PEG2000-DMPE can be used to synthsis a LNP. PEG2000-DMPE enhances the entrapment efficiency depending on the increasing portion in the liposome. The optimal formulation for animal study is that DMPC/PEG2000-DMPE/CH=50/5/45 at the weight ratio of drug/lipid=1/20 [1].
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- HY-153136
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Cationic Lipids
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LNP Lipid-1 (Method B) is a lipid compound. LNP Lipid-1 is involved in the synthesis of lipid nanoparticles compositions. LNP Lipid-1 has potential applications in the transport of biologically active substances such as small molecule agents, proteins, and nucleic acids [1] .
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- HY-150116
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Cationic Lipids
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Lipid 1 is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).
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- HY-156630A
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Cationic Lipids
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Ionizable lipid-1 (compound II-10) is an ionizable lipid (pKa=6.16) that can be used to prepare lipid nanoparticles (LNP) with bilayer structure [1].
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- HY-125818B
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Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate
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Nucleotide Analogs
Cytidine Nucleotide
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Cytidine-5'-triphosphate sodium hydrate (Cytidine triphosphate sodium hydrate; 5'-CTP sodium hydrate) is the sodium hydrate form of Cytidine-5'-triphosphate (HY-125818). Cytidine-5'-triphosphate sodium hydrate is a nucleoside triphosphate, that is invovled in biosynthesis of DNA, RNA and lipid .
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- HY-147018
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Pegylated Lipids
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1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate is a PEG lipid. 1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate can be used for researching drug delivery [1].
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- HY-165427
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Cationic Lipids
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Lipid 11 (Compound Lipid 1) is a cationic lipid for nucleic acid delivery. Lipid 11 forms lipid nanoparticles (LNPs) through electrostatic binding with nucleic acids (such as ceDNA). Lipid 11 forms complexes with negatively charged nucleic acids via cationic amine groups, which can be endocytosed by cells to release nucleic acids for activity. Lipid 11 is promising for research of gene therapy drug delivery systems [1].
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Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-112754AGL
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1,2-Dioleoyl-3-trimethylammonium-propane chloride (GMP Like)
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Liposome
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Others
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DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP chloride is a cationic lipid with good membrane fusion ability and biocompatibility. DOTAP chloride (GMP Like) can be used as an excipient for transient and stable transfection DNA (plasmids, bacmids) and modified nucleic acids (antisense oligonucleotides) without the use of helper lipid .
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![1-Octylnonyl 8-[[8-[(1-ethylnonyl)oxy]-8-oxooctyl](2-hydroxyethyl)amino]octanoate](http://file.medchemexpress.com/product_pic/hy-147018.gif)
