132172-61-3
Chemical Structure
DOTAP chloride
Synonym(s): 1,2-Dioleoyl-3-trimethylammonium-propane chloride
- CAS No.: 132172-61-3
- Formula:C42H80ClNO4
- Molecular Weight:698.54
IUPAC Name: N,N,N-trimethyl-2,3-bis(oleoyloxy)propan-1-aminium chloride
InChIKey: KSXTUUUQYQYKCR-LQDDAWAPSA-M
SMILES: CCCCCCCC/C=C\CCCCCCCC(OCC(OC(CCCCCCC/C=C\CCCCCCCC)=O)C[N+](C)(C)C)=O.[Cl-]
Biological Activity:
DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) chloride is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP chloride promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP chloride can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design
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DOTAP chloride | 99.95% | DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) chloride is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP chloride promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP chloride can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design |
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DOTAP chloride (GMP Like) | DOTAP chloride (GMP Like) is the GMP Like class DOTAP chloride (HY-112754A). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) chloride is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP chloride promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP chloride can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design |
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DOTAP-d9 chloride | DOTAP-d9 (1,2-Dioleoyl-3-trimethylammonium-propane-d9) chloride is the deuterated-labeled DOTAP (chloride) (HY-112754A). DOTAP (1,2-Dioleoyl-3-trimethylammonium-propane) chloride is a cationic lipid reagent, a cationic derivative of trimethylammonium, linked to two 18-carbon fatty acid tails, each with a single olefin group. DOTAP methylsulfat can self-assemble with negatively charged ions (such as DNA) to form complexes, which can be adsorbed to the cell membrane surface and enter the cell by electrostatic interaction and endocytosis, respectively. DOTAP chloride promotes endosomal membrane fusion with its own hydrophobic domain, releases DNA into the cytoplasm, and exerts gene delivery function. DOTAP chloride can be widely used in research fields such as gene therapy, cell transfection, and non-viral vector design |
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Similarity Score 1.00
HY-1651211,2-Dioleoyl-3(R)-trimethylammoniumpropane chloride -
Similarity Score 1.00
HY-1651221,2-Dioleoyl-3(S)-trimethylammoniumpropane chloride -
Similarity Score 0.94
HY-W127426DOTAP mesylate -
Similarity Score 0.93
HY-W127378DOTAP methylsulfate -
Similarity Score 0.92
HY-142995DODAP hydrochloride -
Similarity Score 0.91
HY-130751DODAP -
Similarity Score 0.91
HY-W800776DORI -
Similarity Score 0.88
HY-115767(±)-1,2-Diolein -
Similarity Score 0.88
HY-115767S(±)-1,2-Diolein-CC3 -
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References
- [1]. Kim BK, et al. DOTAP/DOPE ratio and cell type determine transfection efficiency with DOTAP-liposomes. Biochim Biophys Acta. 2015 Oct;1848 (10 Pt A) :1996-2001. [Content Brief]
- [2]. Crook K, et al. Inclusion of cholesterol in DOTAP transfection complexes increases the delivery of DNA to cells in vitro in the presence of serum. Gene Ther. 1998 Jan;5 (1) :137-43. [Content Brief]
