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Results for "

MCL

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) ADC Payload (1) Adenosine Deaminase (2) Akt (6) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (1) Apoptosis (91) Arp2/3 Complex (1) Autophagy (7) Bacterial (2) Bcl-2 Family (143) Beta-lactamase (1) BMI1 (1) Btk (6) c-Myc (13) Calcium Channel (2) Carbonic Anhydrase (1) Caspase (16) CD19 (1) CD20 (1) CDK (32) Ceramidase (1) Checkpoint Kinase (Chk) (1) COX (2) CXCR (1) DNA Alkylator/Crosslinker (2) DNA/RNA Synthesis (11) Drug Derivative (2) Drug Isomer (6) DYRK (2) Endogenous Metabolite (1) ERK (1) Fc Receptor (FcR) (1) Ferroptosis (1) FLT3 (5) Fungal (2) GSK-3 (4) HDAC (1) Histone Acetyltransferase (1) HIV (2) HSP (1) IAP (3) IRAK (4) IRE1 (1) Isotope-Labeled Compounds (1) JAK (3) JNK (1) Ligands for Target Protein for PROTAC (1) LPL Receptor (1) MDM-2/p53 (1) Melanocortin Receptor (2) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) MMP (1) MNK (1) Molecular Glues (1) mTOR (3) MyD88 (4) Necroptosis (1) NF-κB (8) Notch (4) Organoid (1) P-glycoprotein (1) p38 MAPK (1) PARP (4) PDGFR (1) Phosphatase (2) PI3K (1) Pim (1) PIN1 (1) PPAR (1) PROTAC Linkers (1) PROTACs (11) Reactive Oxygen Species (ROS) (3) Reference Standards (12) ROS Kinase (1) Ser/Thr Kinase (1) SF3B1 (1) Small Interfering RNA (siRNA) (7) Src (2) STAT (9) Survivin (6) Syk (3) Topoisomerase (1) VEGFR (1) Virus Protease (1) Wnt (2) β-catenin (1)
By Research Areas:	Cancer (199) Cardiovascular Disease (7) Infection (7) Inflammation/Immunology (19) Metabolic Disease (6) Neurological Disease (7)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (2) Human Pre-designed siRNA Sets (3) siRNAs (7)

217

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-100741

S63845 105+ Cited Publications	Bcl-2 Family	Cancer
S63845 is a potent and selective myeloid cell leukemia 1 (MCL1) inhibitor with a K_d of 0.19 nM for human MCL1 .

HY-112218

MIK665 15+ Cited Publications S-64315	Bcl-2 Family	Cancer
MIK665 (S-64315), derived from S63845, is a myeloid cell leukemia sequence 1 *(MCL1)* inhibitor . MIK665 has an IC₅₀ of 1.81 nM for MCL1 .

HY-101533

AZD-5991 15+ Cited Publications	Bcl-2 Family	Cancer
AZD-5991 is a potent and selective *Mcl-1* inhibitor with an IC₅₀ of 0.7 nM in FRET assay and a K_d of 0.17 nM in surface plasmon resonance (SPR) assay .

HY-18628

UMI-77 4 Publications Verification	Bcl-2 Family	Cancer
UMI-77 is a selective *Mcl-1* inhibitor, which shows high binding affinity to *Mcl-1* (IC₅₀=0.31 μM). UMI-77 binds to the BH3 binding groove of *Mcl-1* with K_i of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

HY-12422

Voruciclib	CDK	Cancer
Voruciclib is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) .

HY-12468

A-1210477 15+ Cited Publications	Bcl-2 Family Apoptosis	Cancer
A-1210477 is a potent and selective inhibitor of *MCL-1* with a K_i of 0.45 nM . A-1210477 specifically binds MCL-1 and promotes apoptosis of cancer cells in an MCL-1-dependent manner .

HY-101565

Tapotoclax 5+ Cited Publications AMG-176	Bcl-2 Family	Cancer
Tapotoclax (AMG-176) is a potent, selective and orally active *MCL-1* inhibitor, with a K_i of 0.13 nM .

HY-125877

*PROTAC Mcl1 degrader-1* 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Mcl1 degrader-1 (compound C3), a proteolysis targeting chimera (PROTAC) based on Cereblon ligand, is a potently and selectively *Mcl-1* (Bcl-2 family member) inhibitor with an IC₅₀ of 0.78 μM. PROTAC Mcl1 degrader-1 inhibits Bcl-2 with an IC₅₀ of 0.54 μM .

HY-132307

Mcl-1 inhibitor 6	Bcl-2 Family Apoptosis	Cancer
Mcl-1 inhibitor 6 is an orally active, selective myeloid cell leukemia 1 (Mcl-1) protein inhibitor with a K_d of 0.23 nM and a K_i of 0.02 μM. Mcl-1 inhibitor 6 possesses superior selectivity over other Bcl-2 family members (Bcl-2, Bcl2A1, Bcl-xL, and Bcl-w, K_d>10 μM). Mcl-1 inhibitor 6 is a potent antitumor agent .

HY-112859

VU0661013	Bcl-2 Family	Cancer
VU661013 is a potent and selective *MCL-1* inhibitor.

HY-125876

PROTAC Bcl2 degrader-1 1 Publications Verification	PROTACs Bcl-2 Family	Cancer
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC based on Cereblon ligand, which potently and selectively induces the degradation of Bcl-2 (IC₅₀, 4.94 μM; DC₅₀, 3.0 μM) and *Mcl-1* (IC₅₀, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1 (Blue: CRBN ligand, Black: linker；Pink: Mcl-1/Bcl-2 inhibitor, Nap-1).

HY-12020

TW-37 4 Publications Verification	Bcl-2 Family	Cancer
TW-37 is a potent Bcl-2 inhibitor with K_i values of 260, 290 and 1110 nM for *Mcl-1, Bcl-2* and Bcl-xL, respectively.

HY-15613

Maritoclax 5+ Cited Publications Marinopyrrole A	Bcl-2 Family	Cancer
Maritoclax (Marinopyrrole A) is a novel and specific *Mcl-1* inhibitor with an IC₅₀ value of 10.1 μM, and shows >8 fold selectivity than BCL-xl (IC₅₀ > 80 μM).

HY-162858

BRD-810	Bcl-2 Family Caspase Apoptosis	Cancer
BRD-810 is a potent and selective *MCL1* inhibitor with a K_d of 0.3 nM. BRD-810 can specifically block the BH3 binding groove of MCL1, while having little effect on other anti-apoptotic proteins (such as Bcl-2, Bcl-xL). BRD-810 effectively destroys the MCL1-BAK complex (IC₅₀ = 1.2 nM) in cancer cells, rapidly activates Caspase and induces cell apoptosis. BRD-810 can be used in the research of various cancers such as hematological tumors and solid tumors .

HY-129700

MCL-1/BCL-2-IN-2	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound 6) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor .

HY-176142

YX0798	CDK c-Myc Apoptosis Bcl-2 Family	Cancer
YX0798 is a selective and orally active CDK9 inhibitor (K_d: 0.28 nM). YX0798 downregulates the oncoprotein c-MYC and pro-survival protein *MCL-1. YX0798 disrupts the cell cycle and results in transcriptomic reprogramming, eventually leading to cell apoptosis*. YX0798 has antitumor activity .

HY-122627

CLZ-8	Bcl-2 Family Apoptosis	Cancer
CLZ-8 (Compound 8) is an orally active *Mcl-1-PUMA* interface inhibitor, with a K_i of 0.3 μM. CLZ-8 exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells .

HY-128360

dMCL1-2	PROTACs Bcl-2 Family Apoptosis Caspase	Cancer
dMCL1-2 is a potent, selective *MCL1* PROTAC degrader based on a Cereblon ligand, with a K_D value of 30 nM for binding to MCL1. dMCL1-2 induces ubiquitination and degradation of MCL1. dMCL1-2 degrades MCL1, cleaves Caspase-3, and induces Apoptosis. dMCL1-2 can be used in research related to multiple myeloma .

HY-109184

Murizatoclax 1 Publications Verification AMG 397	Bcl-2 Family	Cancer
Murizatoclax (AMG 397) is a potent, selective and orally active inhibitor of myeloid leukemia 1 (MCL-1) inhibitor, with a K_i of 15 pM. Murizatoclax competitive binds to the BH3-binding groove of MCL1 with pro-apoptotic BCL-2 family members. Murizatoclax can be used for the research of cancer .

HY-129702

MCL-1/BCL-2-IN-4	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-4 (Compound 7) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor .

HY-129681

MCL-1/BCL-2-IN-1	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-2 (Compound Nap-1) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor with IC₅₀s of 4.45 and 3.18 μM, respectively .

HY-16695

MIM1 Inhibitor of MCL-1	Bcl-2 Family	Cancer
MIM-1 is an inhibitor of myeloid cell factor 1 (Mcl-1).

HY-15805

KIN-8194	Src Btk	Cancer
KIN-8194 is an orally active dual inhibitor of HCK and BTK, with IC₅₀ values of 0.915 and <0.495 nM, respectively. KIN-8194 impairs growth and integrin-mediated adhesion of BTKi-resistant mantle cell lymphoma (MCL). KIN-8194 overcomes ibrutinib (HY-10997) resistance with a survival benefit in TMD-8 ABC DLBCL xenografted mice .

HY-101778

ML311 EU-5346	Bcl-2 Family	Cancer
ML311 is a potent and selective inhibitor of the *Mcl-1/Bim* interaction.

HY-13408

(+)-Apogossypol Apogossypol; NSC736630	Bcl-2 Family	Cancer
(+)-Apogossypol is a pan-BCL-2 antagonist. (+)-Apogossypol binds to *Mcl-1, Bcl-2* and Bcl-xL with EC₅₀s of 2.6, 2.8 and 3.69 µM, respectively.

HY-16669

Mcl1-IN-1	Bcl-2 Family	Cancer
Mcl1-IN-1 is an inhibitor of myeloid cell factor 1 (Mcl-1) (IC₅₀=2.4 µM).

HY-155472

Mcl-1 inhibitor 17	Bcl-2 Family	Cancer
Mcl-1 inhibitor 17 is a Mcl-1 protein inhibitor. Mcl-1 inhibitor 17 can be used for the research of cancer and other diseases .

HY-122830

DD-03-171	PROTACs Btk NF-κB	Cardiovascular Disease Cancer
DD-03-171 is a PROTAC BTK degrader. DD-03-171 inhibits mantle cell lymphoma (MCL) cell proliferation (IC₅₀ = 5.1 nM) and prolongs the survival of mice bearing a lymphoma PDX model by degrading BTK, IKFZ1, and IKFZ3. DD-03-171 also inhibits platelet function and thrombosis. (Pink: BTK ligand 9 (HY-168292); Black: linker (HY-28875); Blue: Thalidomide-NH-CH2-COOH (HY-131717)) .

HY-12527

Pyridoclax 1 Publications Verification MR-29072	Bcl-2 Family	Cancer
Pyridoclax is a potential *Mcl-1* inhibitor.

HY-12422A

Voruciclib hydrochloride	CDK	Cancer
Voruciclib hydrochloride is an orally active and selective CDK inhibitor with K_i values of 0.626 nM-9.1 nM. Voruciclib hydrochloride potently blocks CDK9, the transcriptional regulator of MCL-1. Voruciclib hydrochloride represses expression of MCL-1 in multiple models of diffuse large B-cell lymphoma (DLBCL) .

HY-158783

SACLAC	Ceramidase Bcl-2 Family LPL Receptor Apoptosis	Neurological Disease
SACLAC, a Ceramide analog, is a potent and covalent acid ceramidase (ASAH1; AC) inhibitor with a K_i of 97.1 nM. SACLAC effectively blocks AC activity and induces a decrease in sphingosine 1-phosphate (S1P) and total ceramide levels. SACLAC reduces the levels of splicing factor SF3B1 and alternative Mcl-1 mRNA splicing, increases pro-apoptotic Mcl-1S levels to induce apoptosis in acute myeloid leukemia (AML) cells. SACLAC reduces the leukemic burden in human AML xenograft mouse models .

HY-112591

NSC260594 XMH95	Apoptosis HIV Wnt Bcl-2 Family	Cancer
NSC260594 induces Apoptosis. NSC260594 binds the shallow groove of the *Mcl-1* protein, and inhibits Mcl-1 expression through down-regulation of Wnt signaling proteins. NSC260594 can also recognize G9-G10-A11-G12 RNA tetraloop of HIV and prevent the binding of the Gag protein within the 5’-UTR. NSC260594 inhibits tumor growth, and can be used for research of Triple-negative breast cancers (TNBCs) .

HY-P991225

BI-1206	Fc Receptor (FcR) CD20	Inflammation/Immunology Cancer
BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL) .

HY-163681

Zamzetoclax	Bcl-2 Family	Cancer
Zamzetoclax (compound 1) is a potential *Mcl-1* inhibitor .

HY-101533A

AZD-5991 Racemate	Bcl-2 Family	Cancer
AZD-5991 Racemate is the racemate of AZD-5991. AZD-5991 Racemate is a *Mcl-1* inhibitor with an IC₅₀ of <3 nM in FRET assay.

HY-148203

Mcl-1 inhibitor 9	Bcl-2 Family	Cancer
Mcl-1 inhibitor 9 (example 2) is a myeloid cell leukemia 1 (Mcl-1) inhibitor with IC₅₀ value of 0.21889 nM. Mcl-1 inhibitor 9 shows anti-tumor activity .

HY-129701

MCL-1/BCL-2-IN-3	Bcl-2 Family	Cancer
MCL-1/BCL-2-IN-3 (Compound 2) is a potent and selective *Mcl-1* and Bcl-2 dual inhibitor with IC₅₀s of 5.95 and 4.78 μM, respectively .

HY-RS08230

MCL1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA) Bcl-2 Family	Others
MCL1 Human Pre-designed siRNA Set A contains three designed siRNAs for MCL1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MCL1 Human Pre-designed siRNA Set A MCL1 Human Pre-designed siRNA Set A

HY-164466

CAD204520	Calcium Channel Notch	Cancer
CAD204520, a SERCA inhibitor (IC₅₀ = 0.34 μM), targets mutated over wild type NOTCH1 proteins in T-cell acute lymphoblastic leukemia (T-ALL) and mantle cell lymphoma (MCL). CAD204520 can be used for T-ALL and MCL research .

HY-139453A

LP-284	DNA Alkylator/Crosslinker	Cancer
LP-284 is a potent DNA alkylating agent that kills solid tumours. LP-284 can be used in the studies of hematologic cancers with compromised DNA repair, such as mantle cell lymphoma (MCL) .

HY-150507

JNJ-4355 JNJ-78394355	Bcl-2 Family	Cancer
JNJ-4355, a chemical probe, is a highly potent *MCL-1* (myeloid cell leukemia-1) inhibitor, with K_I of 18 pM. JNJ-4355 shows antitumor activity .

HY-178008

Mcl-1-IN-16	Bcl-2 Family Caspase Apoptosis	Cancer
Mcl-1-IN-16 is an effective macrocyclic myeloid cell leukemia 1 (Mcl-1) inhibitor with a K_i of below 0.08 nM. Mcl-1-IN-16 maintains high selectivity (>50,000-fold) for Mcl-1 over other antiapoptotic Bcl-2 family members Bcl-2 and Bcl-xL. Mcl-1-IN-16 leads to the activation of caspase-3/7, thereby initiating cell apoptosis. Mcl-1-IN-16 achieves tumor regression in a lung cancer-derived tumor xenograft mice model. Mcl-1-IN-16 can be used in the research of solid tumor such as nonsmall cell lung cancer (NSCLC) .

HY-178910

Mcl-1-IN-20	Bcl-2 Family Apoptosis	Cancer
Mcl-1-IN-20 (Compound 26d) is a *Mcl-1* inhibitor with K_is of 0.59, 6.6 and 3.6 μM against *Mcl-1, Bcl-xL* and Bcl-2. Mcl-1-IN-20 exhibits significant anti-proliferative activity against pancreatic cancer cells and can induce apoptosis in BxPC-3 cells. Mcl-1-IN-20 can be used for the study of pancreatic cancer .

HY-178010

Mcl-1-IN-17	Bcl-2 Family Apoptosis	Cancer
Mcl-1-IN-17 (Compound 25) is an orally active Myeloid Cell Leukemia 1 (Mcl-1) inhibitor with a K_i < 0.08  nM. Mcl-1-IN-17 has a significant antiproliferative activity (GI₅₀s of 39 and 105  nM for H929 and A427 cells, respectively) and inhibits cell apoptosis. Mcl-1-IN-17 can be used for hematological and solid cancers research .

HY-159707

MCL1020	Checkpoint Kinase (Chk)	Cardiovascular Disease Cancer
MCL1020 is a CHK1 inhibitor with an IC₅₀ of 1.61 μM. MCL1020 properly occupies the ATP pocket by interacting with a diverse range of the sites of CHK1 kinase. MCL1020 can be used for the study of hematologic malignancies .

HY-100762

Mcl1-IN-11	Bcl-2 Family	Cancer
Mcl1-IN-11 (Compound G) is a selective *Mcl-1* inhibitor, less potent at Bcl-2, with K_is of 0.06 and 4.2 μM, respectively .

HY-145826

Mcl-1 inhibitor 8	Bcl-2 Family	Cancer
Mcl-1 inhibitor 8 is a *MCL-1* inhibitor, example 228, extracted from patent WO2019222112 .

HY-145825

Mcl-1 inhibitor 7	Bcl-2 Family	Cancer
Mcl-1 inhibitor 7 is a potent *Mcl-1* inhibitor, example 35, extracted from patent WO2020097577A .

HY-163293

Mcl-1 inhibitor 18	Bcl-2 Family	Cancer
Mcl-1 inhibitor 18 (compound 57) is a myeloid cell leukemia 1 (Mcl-1) inhibitor, and can be used for study of cancer .

HY-133015

Mcl-1 inhibitor 3	Bcl-2 Family	Cancer
Mcl-1 inhibitor 3 (compound 1) is a highly potent and orally activate macrocyclic *Mcl-1* inhibitor (K_i= 0.061 nM; IC₅₀=19 nM in an OPM-2 cell viability assay). Mcl-1 inhibitor 3 shows good pharmacokinetic properties and excellent in vivo efficacy without toxicity . .

Cat. No.	Product Name	Target	Research Area

HY-P2343

BH3 hydrochloride	Apoptosis	Cancer
BH3 hydrochloride, a BBB penetrated peptide, provoke apoptosis either by direct activation of pro-apoptotic Bax/Bak or by neutralizing anti-apoptotic Bcl-2 proteins (Bcl-2, Bcl-XL, Bcl-w, Mcl-1 and A-1) via their BH3 domian .

HY-107627

MCL0020	Melanocortin Receptor	Inflammation/Immunology
MCL0020 is a potent and selective melanocortin MC4 receptor antagonist, with an IC₅₀ of 11.63 nM. MCL0020 dose-dependently and significantly attenuates restraint stress-induced anorexia without affecting food intake .

HY-P4095

NoxaBH3	CXCR	Cancer
NoxaBH3 is a cysteine-based cross-linked peptide with increased cell permeability and higher inhibitory activity against Mcl-1. NoxaBH3 binds to the endogenous CXCR4 ligand to produce ubiquitin-Noxabh3 conjugate. NoxaBH3 is then delivered to cancer cells .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99956

Zilovertamab vedotin VLS-101; MK-2140	Antibody-Drug Conjugates (ADCs) Apoptosis	Cancer
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer .

HY-P99258

Brontictuzumab OMP 52M51; Anti-Human NOTCH1 Recombinant Antibody	Notch	Cancer
Brontictuzumab (OMP 52M51) is a monoclonal antibody (MAb) that inhibits Notch1 signal. Brontictuzumab selectively binds the negative regulatory region of the Notch1. Brontictuzumab inhibits tumor cell proliferation. Brontictuzumab can be used in the research of leukemia and lymphoma .

HY-P991225

BI-1206	Fc Receptor (FcR) CD20	Inflammation/Immunology Cancer
BI-1206 is a recombinant and antagonistic human monoclonal antibody targeting FcγRIIB (CD32B). BI-1206 can block CD20 internalization induced by Rituximab (HY-P9913) itself or combined with others including Ibrutinib (HY-10997), Venetoclax (HY-15531), and CHOP. BI-1206 can enhance or recover the activity of Rituximab or other anti-CD20 monoclonal antibodies. BI-1206 has cytolytic activity against malignant B cells. BI-1206 can be studied for cancer research such as mantle cell lymphoma (MCL) .

HY-P991899

IKS03 Antibody LCB73 Antibody	ADC Antibody CD19	Cancer
IKS03 Antibody (LCB73 Antibody) is an anti-human CD19 antibody. IKS03 Antibody can generate antibody drug conjugate (ADC) (IKS03) with a pyrrolobenzodiazepine (PBD) dimer payload. IKS03 Antibody can be used for the study of diffuse large B-cell lymphoma (DLBCL) and mantle cell lymphoma (MCL) .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0087

Gambogic Acid 5+ Cited Publications Beta-Guttiferrin	Natural Products Classification of Application Fields Guttiferae Plants Garcinia hanburyi Hook. f. Disease Research Fields Cancer	Bcl-2 Family Autophagy
Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-X_L, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and *Mcl-1* with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N0831

Jaceosidin 5+ Cited Publications	Laburnum anagyroides Medic. Flavonoids Classification of Application Fields Flavones Phenols Polyphenols Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Bcl-2 Family COX Apoptosis
Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .

HY-W040129

Chromomycin A3 1 Publications Verification	Microorganisms Source Classification	DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase
Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-N0763

Angelicin Maximum Cited Publications 11 Publications Verification Isopsoralen	Classification of Application Fields Leguminosae Coumarins Phenylpropanoids Psoralea corylifolia L. Plants Disease Research Fields Source Classification Cancer	Apoptosis Virus Protease NF-κB p38 MAPK JNK Caspase
Angelicin is a furanocoumarin compound that functions as an inhibitor of NF-κB and MAPK signaling pathways, exhibiting anti-inflammatory, antiviral, and antitumor activities. It suppresses the lytic replication of γ-herpesviruses, such as MHV-68, early during viral infection, potentially inhibiting RTA gene expression (IC₅₀=28.95 μM). Angelicin also mitigates inflammation by inhibiting the phosphorylation and nuclear translocation of NF-κB, and the phosphorylation of p38 and JNK. Furthermore, it induces apoptosis in neuroblastoma cells by downregulating anti-apoptotic proteins like Bcl-2, Bcl-xL, and *Mcl-1, while activating caspase-9* and caspase-3.

HY-118341

Clitocine	Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification Cancer	Apoptosis Bcl-2 Family
Clitocine, an adenosine nucleoside analog isolated from mushroom, is a potent and efficacious readthrough agent. Clitocine acts as a suppressor of nonsense mutations and can induce the production of p53 protein in cells harboring p53 nonsense-mutated alleles. Clitocine can induce apoptosis in multidrug-resistant human cancer cells by targeting Mcl-1. Anticancer activity .

HY-15464

(R)-(-)-Gossypol 3 Publications Verification AT-101; R-(-)-gossypol acetic acid	Malvaceae Classification of Application Fields Gossypium Phenols Plants Disease Research Fields Cancer Source Classification	Bcl-2 Family Autophagy
(R)-(-)-Gossypol (AT-101) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, *Mcl-1* and Bcl-xL proteins with K_is of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

HY-N8146

Bruceantinol	Infection Triterpenes Simaroubaceae Classification of Application Fields Brucea antidysenterica J.F.Mill. Terpenoids Plants Disease Research Fields Brucea javanica (L.) Merr. Source Classification Cancer	STAT Bcl-2 Family Ser/Thr Kinase Survivin c-Myc Apoptosis Necroptosis CDK
Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC₅₀ = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of *MCL-1, PTTG1, survivin* and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells .

HY-N3913

Furowanin A	Flavonoids Leguminosae Plants Derris taiwaniana (Hayata) Z. Q. Song Isoflavones Source Classification	STAT Bcl-2 Family
Furowanin A is a flavonoid with anti-neoplastic effects. Furowanin A inhibits *STAT3/Mcl-1* axis to suppress proliferation, block cell cycle progression, induce apoptosis and promote autophagy. Furowanin A potently inhibits colorectal cancer (CRC) cells .

HY-N17676

3-Tridecylphenol	Structural Classification Monophenols Ginkgoaceae Phenols Plants Ginkgo biloba Source Classification	Bcl-2 Family
3-Tridecylphenol is a cardanol. 3-Tridecylphenol can be isolated from K. hookeriana. 3-Tridecylphenol shows K_i values of >23 μM and >33 μM in BclxL/Bak and *Mcl-1/Bid* displacement assays, respectively. 3-Tridecylphenol can be used in cancer research .

HY-N0831R

Jaceosidin (Standard)	Laburnum anagyroides Medic. Flavonoids Classification of Application Fields Phenols Plants Compositae Inflammation/Immunology Disease Research Fields Source Classification	Reference Standards Bcl-2 Family COX Apoptosis
Jaceosidin (Standard) is the analytical standard of Jaceosidin. This product is intended for research and analytical applications. Jaceosidin is a flavonoid isolated from Artemisia vestita, induces apoptosis in cancer cells, activates Bax and down-regulates Mcl-1 and c-FLIP expression . Jaceosidin exhibits anti-cancer , anti-inflammatory activities, decreases leves of inflammatory markers, and suppresses COX-2 expression and NF-κB activation .

HY-N0087R

Gambogic Acid (Standard) Beta-Guttiferrin (Standard)	Structural Classification Natural Products Guttiferae Plants Garcinia hanburyi Hook. f.	Reference Standards Bcl-2 Family Autophagy
Gambogic Acid (Standard) is the analytical standard of Gambogic Acid. This product is intended for research and analytical applications. Gambogic Acid (Beta-Guttiferrin) is derived from the gamboges resin of the tree Garcinia hanburyi. Gambogic Acid (Beta-Guttiferrin) inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC₅₀s of 1.47 μM, 1.21 μM, 2.02 μM, 0.66 μM, 1.06 μM and 0.79 μM.

HY-N7175

5,8-Epidioxyergosta-6,9(11),22-trien-3-ol 9,11-Dehydroergosterol peroxide; 9(11)-DHEP	Classification of Application Fields Solanum lyratum Thunberg Solanaceae Plants Disease Research Fields Steroids Source Classification Cancer	Apoptosis Endogenous Metabolite
5,8-Epidioxyergosta-6,9(11),22-trien-3-ol (9,11-Dehydroergosterol peroxide), an important steroid from medicinal mushroom, exerts antitumor activity in several tumor types. 5,8-Epidioxyergosta-6,9(11),22-trien-3-ol inhibits HT29 cell growth by inducing CDKN1A expression, thus causing cell cycle arrest and apoptosis .

HY-W040129R

Chromomycin A3 (Standard)	Microorganisms Source Classification	Reference Standards Bacterial Fungal Apoptosis Antibiotic
Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg ²⁺. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .

HY-N16746

Nordentatin	Structural Classification Rutaceae Coumarins Phenylpropanoids Plants Clausena excavata N. L. Burman Source Classification	GSK-3 Bcl-2 Family MMP Caspase
Nordentatin is a selective inhibitor targeting GSK-3 with anticancer activity. Nordentatin can inhibit the phosphorylation of GSK-3, downregulate the anti-apoptotic protein *Mcl-1* and activate caspase-3 to induce apoptosis (apoptosis). Nordentatin also inhibits the expression of migration-related protein MMP-9 and exerts anti-proliferation and anti-migration activities. Nordentatin is used in research into cancers such as neuroblastoma .

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HY-P703986

	CD23/Fc epsilon RII Protein, Human (Biotinylated, HEK293, His, Avi) BLAST-2; CD23; CD23A; CLEC4J; FCE2; IGEBF; FCER2; FcεRII; Fcr; Fcgr; Fc receptor; CLEC-6; CLECSF8; MCL; MGC40078; MPCL; Fcer2a; Ly-42	Human	HEK293
	CD23 or Fc epsilon receptor II (Fc epsilon RII) is a low-affinity receptor for immunoglobulin E (IgE) and complements receptor 2 (CR2/CD21). CD23 is present on B cells, regulates IgE production and B cell differentiation, and aids in IgE-dependent antigen uptake. CD23/Fc epsilon RII Protein, Human (Biotinylated, HEK293, His, Avi) is the recombinant human-derived CD23/Fc epsilon RII protein, expressed by HEK293, with N-Avi and N-His labeled tag.

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HY-18628S

UMI-77-d4
UMI-77-d₄ is the deuterium labeled UMI-77. UMI-77 is a selective Mcl-1 inhibitor, which shows high binding affinity to Mcl-1 (IC50=0.31 μM). UMI-77 binds to the BH3 binding groove of Mcl-1 with Ki of 490 nM, showing selectivity over other members of anti-apoptotic Bcl-2 members.

Host:	Mouse (4) Rabbit (4)
Reactivity:	Human (8) Rat (3) Mouse (4)
Application:	IHC-P (5) ICC/IF (6) IP (3) WB (6) FC (5) ELISA (5)
Isotype:	IgG (3) IgG1 (4) IgG/Kappa (1)
Conjugation:	Non-conjugated (8) Biotin (1)
Clonality:	Monoclonal (5) Monoclonal Antibody (1) Recombinant (3)
Modification:	Unmodified (6)

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HY-P84507

	MCL1 Antibody (YA4204) EAT, MCL1L, MCL1S	WB, IHC-P, ICC/IF, ELISA	Human
	MCL1 Antibody (YA4204) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCL1.

HY-P84507A

	MCL1 Antibody (YA4204)(PBS only) EAT, MCL1L, MCL1S	WB, IHC-P, ICC/IF, ELISA	Human
	MCL1 Antibody (YA4204) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to MCL1.

HY-P86177

	MCL1 Antibody (YA5869) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein MCL-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/MCL1; MCL1/EAT	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	MCL1 Antibody (YA5869) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P85269

	MCL1 Antibod (YA4961) MCL1; BCL2L3; Induced myeloid leukemia cell differentiation protein MCL-1; Bcl-2-like protein 3; Bcl2-L-3; Bcl-2-related protein EAT/MCL1; MCL1/EAT	WB, ICC/IF, IP, FC	Human, Mouse, Rat
	MCL1 Antibody (YA4961) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to MCL1.

HY-P84693

	CD368 Antibody (YA4390) CLEC4D; MCL; MPCL; CLEC6; CLEC-6; CLECSF8; Dectin-3	FC, ELISA	Human
	CD368 Antibody (YA4390) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD368.

HY-P80508

	MCL1 Antibody (YA303)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
	MCL1 Antibody (YA303) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to MCL1.

HY-P84693A

	CD368 Antibody (YA4390)(PBS only) CLEC4D; MCL; MPCL; CLEC6; CLEC-6; CLECSF8; Dectin-3	FC, ELISA	Human
	CD368 Antibody (YA4390) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to CD368.

HY-P86907

	HUWE1 Antibody (YA6600) ARF binding protein 1 antibody; ARF BP1 antibody; ARF-binding protein 1 antibody; ARF-BP1 antibody; ARFBP1 antibody; BJ-HCC-24 tumor antigen antibody; E3 ubiquitin protein ligase HUWE1 antibody; E3 ubiquitin-protein ligase HUWE1 antibody; HECT antibody; HECT domain protein LASU1 antibody; ARF binding protein 1 antibody; ARF BP1 antibody; ARF-binding protein 1 antibody; ARF-BP1 antibody; ARFBP1 antibody; BJ-HCC-24 tumor antigen antibody; E3 ubiquitin protein ligase HUWE1 antibody; E3 ubiquitin-protein ligase HUWE1 antibody; HECT antibody; HECT domain protein LASU1 antibody; HECT UBA and WWE domain containing protein 1 antibody; HectH9 antibody; Homologous to E6AP carboxyl terminus homologous protein 9 antibody; Huwe1 antibody; HUWE1_HUMAN antibody; Ib772 antibody; Large structure of UREB1 antibody; LASU1 antibody; MCL 1 ubiquitin ligase E3 antibody; MCL-1 ubiquitin ligase E3 antibody; Mule antibody; UBA and WWE domain-containing protein 1 antibody; Upstream regulatory element-binding protein 1 antibody; URE-B1 antibody; URE-binding protein 1 antibody; UREB1 antibody;	WB, IHC-P, ICC/IF, FC	Human, Mouse, Rat
	HUWE1 Antibody (YA6600) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to HUWE1.

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