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Results for "

ME2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adrenergic Receptor (1) Amino Acid Derivatives (1) Amyloid-β (1) Androgen Receptor (1) Apoptosis (21) Autophagy (6) Bcl-2 Family (1) Biochemical Assay Reagents (8) Caspase (1) CD44 (1) Cytochrome P450 (1) DNA/RNA Synthesis (2) Drug Derivative (1) EGFR (1) Endogenous Metabolite (5) GLP Receptor (1) Glucocorticoid Receptor (1) GSK-3 (1) HIF/HIF Prolyl-Hydroxylase (1) Histone Demethylase (21) Histone Methyltransferase (39) Isotope-Labeled Compounds (4) Microtubule/Tubulin (6) Nucleoside Antimetabolite/Analog (8) Oxytocin Receptor (3) Phosphoramidites (8) PROTAC Linkers (1) PROTACs (3) Reactive Oxygen Species (ROS) (7) Reference Standards (4) Small Interfering RNA (siRNA) (6) STAT (1) Tau Protein (1) Vasopressin Receptor (2) WDR5 (1) Wee1 (1)
By Research Areas:	Cancer (66) Cardiovascular Disease (1) Endocrinology (1) Infection (1) Inflammation/Immunology (3) Metabolic Disease (10) Neurological Disease (6)
Oligonucleotides:	Nucleotide Analogs (1) Nucleoside Analogs (1) Adenine (4) Rat Pre-designed siRNA Sets (1) Cytosine (1) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (2) Uracil (2) Other Phosphoramidite (1) Phosphoramidites (8) siRNAs (6)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Targets Recommended: Measles Virus

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15648B

GSK-J4 Maximum Cited Publications 55 Publications Verification	Histone Demethylase Apoptosis	Cancer
GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 ^[2] . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-12033

2-Methoxyestradiol 30+ Cited Publications 2-ME2; NSC-659853	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-D0858

MES 4 Publications Verification 2-Morpholinoethanesulphonic acid	Biochemical Assay Reagents	Others
MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-15227

EPZ004777 5+ Cited Publications	Histone Methyltransferase Apoptosis	Inflammation/Immunology Cancer
EPZ004777 is an effective and selective DOT1L inhibitor, with IC₅₀ being 0.4 nM. EPZ004777 reduces the levels of *H3K79me2* and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 can be used for the study of leukemia ^[2] .

HY-15648F

GSK-J4 hydrochloride Maximum Cited Publications 55 Publications Verification	Histone Demethylase	Cancer
GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC₅₀s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC₅₀ of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 ^[2] .

HY-154812

Gintemetostat KTX-1001	Histone Methyltransferase CD44	Cancer
Gintemetostat (KTX-1001) is an orally active, highly specific NSD2/MMSET histone methyltransferase inhibitor with human *NSD2* IC₅₀ values ranging 0.460-2.17 nM and *NSD2* SET domain IC₅₀ of 2.32 nM and K_d values ranging 6.3-70.4 nM .Gintemetostat reduces H₃K₃₆me₂ levels, impairs multiple myeloma cell adhesion and colony formation, enhances cytotoxicity, boosts T-cell activation, and sensitizes resistant multiple myeloma cells to other agents ^[2] .Gintemetostat can be used for the research of multiple myeloma and relapsed and refractory multiple myeloma ^[2] .

HY-15648

GSK-J1 15+ Cited Publications	Histone Demethylase	Cancer
GSK-J1, a chemical probe, is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀ of 60 nM towards KDM6B.

HY-D0858A

MES monohydrate 4 Publications Verification 2-Morpholinoethanesulphonic acid monohydrate	Biochemical Assay Reagents	Others
MES (2-Morpholinoethanesulphonic acid) monohydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES monohydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2] .

HY-13808

UNC 0631 5 Publications Verification	Histone Methyltransferase	Cancer
UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC₅₀ of 4 nM. UNC 0631 potently reduces *H3K9me2* levels in MDA-MB-231 cells with an IC₅₀ of 25 nM .

HY-15648A

GSK-J2 4 Publications Verification	Histone Demethylase	Cancer
GSK-J2 is an isomer of GSK-J1 that does not have any specific activity. GSK-J1 is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A.

HY-D0858C

MES hydrate 4 Publications Verification 2-Morpholinoethanesulphonic acid hydrate	Biochemical Assay Reagents	Others
MES (2-Morpholinoethanesulphonic acid) hydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858E

MES potassium 4 Publications Verification 2-Morpholinoethanesulphonic acid potassium	Biochemical Assay Reagents	Others
MES (2-Morpholinoethanesulphonic acid) potassium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES potassium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-152775

RK-701	Histone Methyltransferase	Cancer
RK-701 is an highly selective and non-genotoxic inhibitor of G9a with IC₅₀ value of 23-27 nM. RK-701 selectively up-regulates HbF, γ- Globin, BGLT3 expression, down-regulates H3K9me2 expression. RK-701 also has inhibition for BCL11A and ZBTB7A .

HY-13807

UNC0646 1 Publications Verification	Histone Methyltransferase	Cancer
UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC₅₀ of 6 nM. UNC0646 is also a potent GLP inhibitor (IC₅₀ <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces *H3K9me2* levels in MDA-MB-231 cells with an IC₅₀ of 26 nM .

HY-162275

JMJD1C-IN-1	Histone Demethylase Histone Methyltransferase STAT	Cancer
JMJD1C-IN-1 is an orally active and selective inhibitor of JMJD1C (IC₅₀ = 0.59 μM, K_d = 1.96 μM). JMJD1C-IN-1 inhibits the binding of JMJD1C to H3K9me2 peptide substrate in the HTRF assay (IC₅₀ = 1.47 μM). JMJD1C-IN-1 disrupts intratumoral regulatory T (Treg) cell fitness by dual mechanisms: promoting *H3K9me2* accumulation to downregulate PD1 expression and reducing STAT3 demethylation to enhance STAT3 activation. JMJD1C-IN-1 demonstrates dose-dependent antitumor efficacy in multiple mouse tumor models (MCA205 fibrosarcoma, B16-F10 melanoma, LLC lung cancer, Hepa1-6 hepatocellular carcinoma, CT26 colorectal cancer). JMJD1C-IN-1 can be used for the study of tumor immunotherapy by selectively targeting intratumoral Treg cells .

HY-12033S2

2-Methoxyestradiol-d5 2-ME2-d₅; NSC-659853-d₅	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-100360

MS049 1 Publications Verification	Histone Methyltransferase	Cancer
MS049, a chemical probe, is a potent, selective, and cell-active dual inhibitor of PRMT4 and PRMT6 with IC₅₀s of 34 nM and 43 nM, respectively. MS049 reduces levels of Med12me2a and H3R2me2a in HEK293 cells. MS049 is not toxic and does not affect the growth of HEK293 cells .

HY-145103

UNC6934	Histone Methyltransferase	Cancer
UNC6934 is a selective NSD2-PWWP1 antagonist with IC₅₀ values of 78 nM and 104 nM, and a K_a of 91 nM against human targets. UNC6934 binds to the canonical methyl-lysine binding pocket of NSD2-PWWP1 and directly competes with H3K36me2 for binding. UNC6934 induces the aggregation of NSD2 within the nucleolus, without altering ribosomal RNA transcription, global H3K36me2 levels or the proliferation of KMS-11 cells. UNC6934 can be used in studies related to multiple myeloma and diffuse intrinsic pontine glioma. ^[2]

HY-13808R

UNC 0631 (Standard)	Reference Standards Histone Methyltransferase	Cancer
UNC 0631 (Standard) is the analytical standard of UNC 0631. This product is intended for research and analytical applications. UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC₅₀ of 4 nM. UNC 0631 potently reduces *H3K9me2* levels in MDA-MB-231 cells with an IC₅₀ of 25 nM .

HY-157251

UNC8153 TFA	Histone Methyltransferase	Cancer
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein (DC₅₀ in cell U2OS is 0.35 μM) and the *H3K36me2* chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

HY-15648D

GSK-J1 lithium salt 15+ Cited Publications	Histone Demethylase	Cancer
GSK-J1 lithium salt is a potent inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A, with IC₅₀ of 60 nM towards KDM6B.

HY-15227A

EPZ004777 hydrochloride 5+ Cited Publications	Histone Methyltransferase Apoptosis	Inflammation/Immunology Cancer
EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor, with IC₅₀ being 0.4 nM. EPZ004777 hydrochloride reduces the levels of *H3K79me2* and H3K79me1, significantly down-regulating the expression of HOXA9 and MEIS1. EPZ004777 hydrochloride selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis (apoptosis) of leukemia cells. EPZ004777 hydrochloride can be used for the study of leukemia ^[2] .

HY-162749A

G9D-4 TFA	PROTACs Histone Methyltransferase Apoptosis	Cancer
G9D-4 TFA is a G9a PROTAC degrader. G9D-4 TFA induces G9a degradation, reduces *H3K9me2* levels, and prevents GLP interference via the CRBN ternary complex, proteasome and ubiquitin-like modification-dependent pathways. G9D-4 TFA exerts antiproliferative activity and induces Apoptosis in pancreatic cancer cells. G9D-4 TFA can be used for research on pancreatic cancer .

HY-168992

UNC6535	Histone Methyltransferase	Neurological Disease Cancer
UNC6535 is a covalent ligand targeting the SETDB1 triple Tudor domain (3TD) with negative allosteric modulator properties, with an IC₅₀ of 3.4 μM and a K_d of 4.2 μM. UNC6535 inhibits the methyltransferase activity of recombinant SETDB1 protein lacking the 3TD domain. UNC6535 reversibly binds to the aromatic cages of both TD2 and TD3 subdomains of SETDB1 3TD simultaneously, displacing the endogenous H3K9Me2K14Ac histone tail ligand. UNC6535 can be used in research on cancer and neurodegenerative diseases ^[2].

HY-161313

DYB-03	Histone Methyltransferase HIF/HIF Prolyl-Hydroxylase	Cancer
DYB-03 is an oral active *HIF-1α/EZH2* inhibitor. DYB-03 inhibits migration, invasion, and angiogenesis of lung cancer cells and HUVECs in vitro and in vivo. DYB-03 induces apoptosis in 2-ME2 ^- and GSK126 ^-resistant of A549 and H460 cells .

HY-128579

DW14800	Histone Methyltransferase	Cancer
DW14800 is a protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC₅₀ of 17 nM. DW14800 reduces H4R3me2s levels and enhances the transcription of HNF4α, but does not alter PRMT5 expression. Anti-cancer activity .

HY-D0858S

MES-d13	Isotope-Labeled Compounds Biochemical Assay Reagents	Others
MES-d₁₃ is the deuterium labeled MES. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2] .

HY-D0858AR

MES monohydrate (Standard) 2-Morpholinoethanesulphonic acid monohydrate (Standard)	Biochemical Assay Reagents Reference Standards	Others
MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-156285

ZZM-1220	Histone Methyltransferase Apoptosis	Cancer
ZZM-1220 is a histone lysine methyltransferase G9a/GLP covalent inhibitor with IC₅₀s of of 458 nM and 924 nM, respectively. ZZM-1220 inhibits H3K9me2 in cells and significantly induces apoptosis of triple-negative breast cancer (TNBC) cells and blocks the cell cycle in the G2/M phase .

HY-157251A

UNC8153	Histone Methyltransferase	Cancer
UNC8153 is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2)-targeted degrader with a K_d of 24 nM. UNC8153 reduces the cellular levels of both NSD2 protein (DC₅₀ in cell U2OS is 0.35 μM) and the *H3K36me2* chromatin mark. UNC8153 contains a simple warhead that confers proteasome-dependent degradation of NSD2 .

HY-44062

G9a-IN-1	Histone Methyltransferase	Inflammation/Immunology Cancer
G9a-IN-1 (Compound 113) is a G9a protein inhibitor. G9A/EHMT2 is a nuclear histone lysine methyltransferase that catalyzes histone H3 lysine 9 dimethylation (H3K9me2), which is a reversible modification generally associated with transcriptional gene silencing. G9a-IN-1 can be used for the research of autoimmune disorders or cancer .

HY-162749

G9D-4	PROTACs Histone Methyltransferase Apoptosis	Cancer
G9D-4 is a G9a PROTAC degrader. G9D-4 induces G9a degradation, reduces *H3K9me2* levels, and prevents GLP interference via the CRBN ternary complex, proteasome and ubiquitin-like modification-dependent pathways. G9D-4 exerts antiproliferative activity and induces Apoptosis in pancreatic cancer cells. G9D-4 can be used for research on pancreatic cancer .

HY-150510

MS8511	Histone Methyltransferase	Neurological Disease Cancer
MS8511 is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC₅₀ values of 100 nM (G9a) and 140 nM (GLP), and K_d values of 44 nM (G9a) and 46 nM (GLP). MS8511 reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader−Willi syndrome (PWS) .

HY-66025

*Fmoc-Lys(Me)2-OH hydrochloride*	Amino Acid Derivatives	Others
Fmoc-Lys(Me)2-OH HCl is a lysine derivative .

HY-RS08271

ME2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ME2 Human Pre-designed siRNA Set A contains three designed siRNAs for ME2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ME2 Human Pre-designed siRNA Set A ME2 Human Pre-designed siRNA Set A

HY-RS24141

Me2 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Me2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Me2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Me2 Rat Pre-designed siRNA Set A Me2 Rat Pre-designed siRNA Set A

HY-RS17680

Me2 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Me2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Me2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Me2 Mouse Pre-designed siRNA Set A Me2 Mouse Pre-designed siRNA Set A

HY-P4397

*(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin*	Oxytocin Receptor	Endocrinology
(d(CH2)51,Tyr(Me)2,Thr4,Orn8,des-Gly-NH29)-Vasotocin, an oxytocin receptor antagonist, abolishes oxytocin-enhanced inhibitory postsynaptic currents in CA1 pyramidal neurons .

HY-D0858D

MES hemisodium 4 Publications Verification 2-Morpholinoethanesulphonic acid hemisodium	Biochemical Assay Reagents	Others
MES (2-Morpholinoethanesulphonic acid) hemisodium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hemisodium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-15313C

CBB1007 trihydrochloride 2 Publications Verification	Histone Demethylase	Metabolic Disease Cancer
CBB1007 trihydrochloride is a reversible and selective LSD1 inhibitor with an IC₅₀ of 5.27 µM for human LSD1. CBB1007 trihydrochloride significantly blocks the demethylase activity of LSD1 on H3K4Me2 and H3K4Me. CBB1007 trihydrochloride shows selectivity for LSD1 over LSD2 or JARID1A, and induces differentiation-related genes in pluripotent cells. CBB1007 trihydrochloride is studied in non-pluripotent cancer research, targeting teratocarcinoma, embryonic carcinoma, and seminoma ^[2].

HY-150510A

MS8511 hydrochloride	Histone Methyltransferase	Neurological Disease Cancer
MS8511 (hydrochloride) is a selective G9a/GLP covalent irreversible inhibitor by targeting a cysteine residue at the substrate binding site, with IC₅₀ values of 100 nM (G9a) and 140 nM (GLP), and K_d values of 44 nM (G9a) and 46 nM (GLP). MS8511 (hydrochloride) reduces the cellular H3K9me2 level and enhances antiproliferation activity. MS8511 (hydrochloride) can be used for the research of several types of cancers including brain, breast, ovarian, lung, bladder, melanoma, colorectal cancer, and other disease such as Alzheimer’s disease (AD), sickle cell disease, Prader−Willi syndrome (PWS) .

HY-120766

NCDM-32B	Histone Demethylase	Cancer
NCDM-32B is a potent and selective KDM4 inhibitor, with IC₅₀ values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global *H3K9me3/me2* levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824). NCDM-32B can be used for the study of breast cancer ^[2].

HY-179427

NSD2/H3K36me2 modulator-1	Histone Methyltransferase Apoptosis Reactive Oxygen Species (ROS)	Cancer
NSD2/H3K36me2 modulator-1 is an orally active *NSD2/H3K36me2* modulator. NSD2/H3K36me2 modulator-1 competitively binds to the SAM pocket of NSD2, potently inhibits NSD2 expression and suppresses H3K36me2 methylation. NSD2/H3K36me2 modulator-1 reverses epithelial-mesenchymal transition (EMT), inhibits cell migration, and induces G0/G1 phase arrest and apoptosis. NSD2/H3K36me2 modulator-1 induces decreased Mitochondrial membrane potential (MMP) and subsequent Reactive oxygen species (ROS) generation. NSD2/H3K36me2 modulator-1 can be used to research the NSD2-targeting epigenetic anticancer strategies for hepatocellular carcinoma (HCC) .

HY-154224

*2’-O-Me-2-thio-U-3’-phos phoramidite*	Nucleoside Antimetabolite/Analog Phosphoramidites	Cancer
2’-O-Me-2-thio-U-3’-phos phoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc .

HY-12033S1

2-Methoxyestradiol-13C6 2-ME2-¹³C₆; NSC-659853-¹³C₆	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-P2253

*H3K27(Me2) (15-34)*	Histone Demethylase	Cancer
H3K27(Me2) (15-34), a histone peptide, is a repressive chromatin mark derived from human histone. Polycomb Repressive Complex 2 (PRC2) is a multiprotein complex that catalyzes the methylation of H3K27(Me) ^[2].

HY-12033S

2-Methoxyestradiol-13C,d3	Isotope-Labeled Compounds Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite	Cancer
2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-15648FR

GSK-J4 hydrochloride (Standard)	Histone Demethylase	Cancer
GSK-J4 (hydrochloride) (Standard) is the analytical standard of GSK-J4 (hydrochloride). This product is intended for research and analytical applications. GSK-J4 hydrochloride is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 hydrochloride inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK-J4 hydrochloride is a cell permeable proagent of GSK-J1 ^[2] .

HY-15648BR

GSK-J4 (Standard)	Histone Demethylase Apoptosis	Cancer
GSK-J4 (Standard) is the analytical standard of GSK-J4. This product is intended for research and analytical applications. GSK-J4 is a potent dual inhibitor of H3K27me3/me2-demethylases JMJD3/KDM6B and UTX/KDM6A with IC50s of 8.6 and 6.6 μM, respectively. GSK-J4 inhibits LPS-induced TNF-α production in human primary macrophages with an IC50 of 9 μM. GSK J4 is a cell permeable proagent of GSK-J1 ^[2] . GSK-J4 induces endoplasmic reticulum stress-related apoptosis .

HY-P5006

*(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin* d(CH2)5[Tyr(ME)2, Dab5]AVP	Vasopressin Receptor	Cardiovascular Disease
(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin (d(CH2)5[Tyr(Me)2, Dab5]AVP) is a specific antagonist of vasopressin V_1a receptor, with a pA₂ of 6.71 .

Cat. No.	Product Name	Type

HY-D0858

MES 4 Publications Verification 2-Morpholinoethanesulphonic acid	Biochemical Assay Reagents
MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858A

MES monohydrate 4 Publications Verification 2-Morpholinoethanesulphonic acid monohydrate	Biochemical Assay Reagents
MES (2-Morpholinoethanesulphonic acid) monohydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES monohydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2] .

HY-D0858C

MES hydrate 4 Publications Verification 2-Morpholinoethanesulphonic acid hydrate	Biochemical Assay Reagents
MES (2-Morpholinoethanesulphonic acid) hydrate is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hydrate is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858E

MES potassium 4 Publications Verification 2-Morpholinoethanesulphonic acid potassium	Biochemical Assay Reagents
MES (2-Morpholinoethanesulphonic acid) potassium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES potassium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858AR

MES monohydrate (Standard)

2-Morpholinoethanesulphonic acid monohydrate (Standard)

Biochemical Assay Reagents

MES (monohydrate) (Standard) is the analytical standard of MES (monohydrate). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858D

MES hemisodium 4 Publications Verification 2-Morpholinoethanesulphonic acid hemisodium	Biochemical Assay Reagents
MES (2-Morpholinoethanesulphonic acid) hemisodium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hemisodium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

HY-D0858DR

MES hemisodium (Standard)

2-Morpholinoethanesulphonic acid hemisodium (Standard)

Biochemical Assay Reagents

MES (hemisodium) (Standard) is the analytical standard of MES (hemisodium). This product is intended for research and analytical applications. MES (2-Morpholinoethanesulphonic acid) hemisodium is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES hemisodium is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2].

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-12033

2-Methoxyestradiol 30+ Cited Publications 2-ME2; NSC-659853	Monophenols Classification of Application Fields Disease markers Phenols Endocrine diseases Endogenous metabolite Disease Research Fields Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite
2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-12033R

2-Methoxyestradiol (Standard) 2-ME2 (Standard); NSC-659853 (Standard)	Structural Classification Monophenols Disease markers Phenols Endocrine diseases Endogenous metabolite Steroids Cancer Source Classification	Microtubule/Tubulin Reactive Oxygen Species (ROS) Apoptosis Autophagy Endogenous Metabolite Reference Standards
2-Methoxyestradiol (Standard) is the analytical standard of 2-Methoxyestradiol. This product is intended for research and analytical applications. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

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HY-P71918A

	NAD-ME Protein, Human (His) Malate dehydrogenase; Malic enzyME 2; Malic enzyME 2 mitochondrial; Malic enzyME 2 NAD+; dependent mitochondrial; Malic enzyME mitochondrial; Malic enzyME NAD+; dependent mitochondrial; MAOM_HUMAN; ME 2; ME2; mitochondrial; NAD dependent malic enzyME mitochondrial; NAD ME; NAD-dependent malic enzyME; NAD-ME; ODS1; Pyruvic malic carboxylase	Human	E. coli
	NAD-ME, a mitochondrial malic enzyme, relies on NAD and catalyzes the oxidative decarboxylation of malate to pyruvate within the mitochondria. Essential for cellular energy metabolism and the tricarboxylic acid (TCA) cycle, NAD-ME links metabolic pathways, influencing energy production and precursor molecule generation. Its enzymatic role is pivotal for balancing cellular redox reactions and meeting the cell's metabolic demands. NAD-ME Protein, Human (His) is the recombinant human-derived NAD-ME protein, expressed by E. coli , with C-6*His labeled tag.

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Source
Tag
Accession
Gene ID
Molecular Weight
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Shipping
Free Sample	Yes No
Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Cat. No.	Product Name	Chemical Structure

HY-12033S2

2-Methoxyestradiol-d5

2-Methoxyestradiol-d₅ is the deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-D0858S

MES-d13
MES-d₁₃ is the deuterium labeled MES. MES (2-Morpholinoethanesulphonic acid) is a kind of amphoteric ion buffer, the buffer capacity ranging pH 5.5-7.0. As a Good's buffer, MES is widely used in biochemistry and molecular biology experiments, such as cell culture, enzyme activity determination, electrophoresis and protein studies ^[2] .

HY-12033S1

2-Methoxyestradiol-13C6

2-Methoxyestradiol- ¹³C₆ is the ¹³C-labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-12033S

2-Methoxyestradiol-13C,d3

2-Methoxyestradiol- ¹³C,d₃ is the ¹³C- and deuterium labeled 2-Methoxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa ^[2] .

HY-168968S

ZJY-54
ZJY-54 is an orally active dual-target inhibitor of EGFR/LSD1, with IC₅₀ values of 3.8 nM and 0.6 μM, respectively. ZJY-54 can inhibit the proliferation of non-small cell lung cancer cells, induce the accumulation of H3K4me2 and H3K9me2, and inhibit the phosphorylation of the EGFR signaling pathway. ZJY-54 has anti-tumor activity .

Host:	Mouse (4) Rabbit (4)
Reactivity:	Human (8) Rat (8) Mouse (8)
Application:	IHC-P (3) ICC/IF (7) IF-Tissue (1) IP (4) WB (8) ChIP (1) ELISA (2)
Isotype:	IgG (3) IgG1 (3) IgG/Kappa (1)
Conjugation:	Non-conjugated (8)
Clonality:	Monoclonal (6) Recombinant (1)
Modification:	Methylated (5) Unmodified (1)

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HY-P83310

	ME2 Antibody (YA3055) ODS1	WB, ICC/IF	Human, Mouse, Rat
	ME2 Antibody (YA3055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ME2.

HY-P83310A

	ME2 Antibody (YA3055)(PBS only) ODS1	WB, ICC/IF	Human, Mouse, Rat
	ME2 Antibody (YA3055) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to ME2.

HY-P80643

	DiMethyl-Histone H3 Antibody (YA783) H3K27ME2; H3 histone; HIST1H3A; Histone cluster 1; H3a	WB, ICC/IF, IP	Human, Mouse, Rat
	DiMethyl-Histone H3 Antibody (YA783) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DiMethyl-Histone H3.

HY-P80643A

	DiMethyl-Histone H3 Antibody (YA783)(PBS only) H3K27ME2; H3 histone; HIST1H3A; Histone cluster 1; H3a	WB, ICC/IF, IP	Human, Mouse, Rat
	DiMethyl-Histone H3 Antibody (YA783) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to DiMethyl-Histone H3.

HY-P80176

	Histone H3 (tri methyl K9) Antibody (YA734) H3K9ME3; H3 histone family MEmber E pseudogene; H3 histone family, MEmberA; H3/A; H31_HUMAN; H3F3; H3FA; Hist1h3a; HIST1H3B; HIST1H3C; HIST1H3D; HIST1H3E; HIST1H3F; HIST1H3G; HIST1H3H; HIST1H3I; HIST1H3J; HIST3H3; histone 1, H3a; Histone cluster 1, H3a; Histone H3 3 pseudogene; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; HistoneH3/l; H3K9ME2; HistoneH3(triMEthylK9)	WB, IHC-P, ICC/IF, IF-Tissue	Human, Mouse, Rat
	Histone H3 (tri methyl K9) Antibody (YA734) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Histone H3 (tri methyl K9).

HY-P86113

	Histone H3 (Di Methyl Lys4) Antibody (YA5805) H3K4ME2; HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3.1; Histone H3.2; Histone H3/m; Histone H3/o; H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; Histone H3.3; H3F3C; Histone H3.3C; Histone H3.5	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	Histone H3 (Di Methyl Lys4) Antibody (YA5805) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H3 (Di Methyl Lys4).

HY-P86148

	Histone H3 (Di Methyl Lys9) Antibody (YA5840) H3K9ME2; HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; HIST2H3A; HIST2H3C; H3F2; H3FM; HIST2H3D; Histone H3.2; Histone H3/m; Histone H3/o; H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; Histone H3.3	WB, IHC-P, ICC/IF, IP, ChIP, ELISA	Human, Mouse, Rat
	Histone H3 (Di Methyl Lys9) Antibody (YA5840) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H3 (Di Methyl Lys9).

HY-P85670

	Histone H3 (Di Methyl Lys79) Antibody (YA5362) H3K79ME2; HIST1H3A; H3FA; HIST1H3B; H3FL; HIST1H3C; H3FC; HIST1H3D; H3FB; HIST1H3E; H3FD; HIST1H3F; H3FI; HIST1H3G; H3FH; HIST1H3H; H3FK; HIST1H3I; H3FF; HIST1H3J; H3FJ; Histone H3.1; Histone H3/a; Histone H3/b; Histone H3/c; Histone H3/d; Histone H3/f; Histone H3/h; Histone H3/i; Histone H3/j; Histone H3/k; Histone H3/l; HIST2H3A; HIST2H3C; H3F2; H3FM; HIST2H3D; Histone H3.2; Histone H3/m; Histone H3/o; H3F3A; H3.3A; H3F3; PP781; H3F3B; H3.3B; Histone H3.3	WB	Human, Mouse, Rat
	Histone H3 (Di Methyl Lys79) Antibody (YA5362) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Histone H3 (Di Methyl Lys79).

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ME2

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