1320288-17-2
Chemical Structure
UNC0646
- CAS No.: 1320288-17-2
- Formula:C36H59N7O2
- Molecular Weight:621.90
IUPAC Name: N-(1-cyclohexylpiperidin-4-yl)-2-(4-isopropyl-1,4-diazepan-1-yl)-6-methoxy-7-(3-(piperidin-1-yl)propoxy)quinazolin-4-amine
InChIKey: OUKWLRHRXOPODD-UHFFFAOYSA-N
SMILES: COC1=CC2=C(NC3CCN(C4CCCCC4)CC3)N=C(N5CCN(C(C)C)CCC5)N=C2C=C1OCCCN6CCCCC6
Biological Activity: UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM[1].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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UNC0646 | 99.38% | UNC0646 is a potent and selective histone methyltransferase G9a inhibitor with an IC50 of 6 nM. UNC0646 is also a potent GLP inhibitor (IC50 <15 nM) and highly selective for G9a/GLP over SETD7, SUV39H2, SETD8 and PRMT3. UNC0646 reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 26 nM. | ||||||||||||||||||||
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Similarity Score 0.90
HY-13808RUNC 0631 (Standard) -
Similarity Score 0.76
HY-13980UNC0642 -
Similarity Score 0.70
HY-10929UNC0224 -
Similarity Score 0.70
HY-110093UNC0638 hydrate -
Similarity Score 0.70
HY-103364ARC-021 dihydrochloride (Standard) -
Similarity Score 0.70
HY-15273UNC0638 -
Similarity Score 0.70
HY-103364RC-021 (Standard) -
Similarity Score 0.70
HY-159989UNC10142 -
Similarity Score 0.69
HY-187077UNC0642-C3-COOH -
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