MMP2-IN-2

By Targets:	Apoptosis (3) Biochemical Assay Reagents (2) Calcium Channel (1) COX (2) Ferroptosis (1) Integrin (1) Mitochondrial Metabolism (1) MMP (9) NF-κB (1) Protease Activated Receptor (PAR) (1) Reactive Oxygen Species (ROS) (1) STAT (1) Toll-like Receptor (TLR) (1) VEGFR (1)
By Research Areas:	Cancer (9) Cardiovascular Disease (1) Inflammation/Immunology (1)
Oligonucleotides:	Polymers (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-MaleimidoethylamINe hydrochloride	Biochemical Assay Reagents	Cancer
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare *MMP-2*-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-SuccINimidyl ester	Biochemical Assay Reagents MMP	Cancer
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of *MMP-2*-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize *MMP-2*-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

HY-147745

*MMP2-IN-2*	MMP	Cancer
MMP2-IN-2 (compound 42) is a potent and selective *MMP-2* (matrix metalloproteinases) inhibitor, with an IC₅₀ of 4.2 μM. MMP2-IN-2 also shows inhibitory activity against MMP-13, MMP-9 and MMP-8, with IC₅₀ values of 12, 23.3, and 25 μM, respectively .

HY-N16129

Diplacone Nymphaeol A; PropolIN C	COX Reactive Oxygen Species (ROS) Calcium Channel Ferroptosis Mitochondrial Metabolism MMP	Inflammation/Immunology Cancer
Diplacone is an orally active geranyl flavanone. It is isolated from the fruits of Paulownia tomentosa. Diplacone reduces COX-2 levels and increases the *pro-MMP2/MMP2* ratio. It induces ferroptosis-mediated cell death. Diplacone enhances mitochondrial Ca ²⁺ influx and ROS production. It possesses anti-inflammatory and free radical-scavenging activities. Diplacone can be used in research related to ulcerative colitis and non-small cell lung cancer .

HY-N7385

Nudol	MMP Apoptosis	Cancer
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and MMP-9 activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-165386

TU-100	Toll-like Receptor (TLR) NF-κB STAT MMP COX VEGFR	Cancer
TU-100 is a Japanese herbal medicine. TU-100 exhibits anti-cancer effects by regulating cancer-associated fibroblasts (CAFs) in the TME. TU-100 can antagonize the M2 polarization phenotype of macrophages in the tumor microenvironment by suppressing the TLR4/NF-κB/STAT3 axis. TU-100 can inhibit the high expression of *MMP-2, COX-2*, and VEGF in TAMs .

HY-P5764

TRAP-14 amide	Protease Activated Receptor (PAR) Integrin MMP	Cardiovascular Disease
TRAP-14 amide, a proteinase activated receptor (PAR)-activating peptide, is a PAR agonist with an EC₅₀ of 24 μM. TRAP-14 amide significantly induces platelet aggregation through ADP- and *MMP-2*-dependent pathways with Aspirin (HY-14654)-insensitivity. TRAP-14 amide also effectively increases glycoprotein (GP) Ib and GPIIb/IIIa surface expression and ADP release .

HY-P11746

GPLGIAGQC	MMP	Cancer
GPLGIAGQC is an *MMP2*-cleavable peptide . In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by *MMP2* between the glycine and isoleucine residues. After *MMP2*-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles .

Cat. No.	Product Name	Type

HY-W068119A

N-(2-Aminoethyl)maleimide hydrochloride 2-MaleimidoethylamINe hydrochloride	Biochemical Assay Reagents
N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare *MMP-2*-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .

N-(2-Aminoethyl)maleimide hydrochloride

2-MaleimidoethylamINe hydrochloride

Biochemical Assay Reagents

N-(2-Aminoethyl)maleimide (2-Maleimidoethylamine) hydrochloride is a selective covalent binding agent for thiol groups (RSGs), covalently binding to thiols via an irreversible thioether bond to prepare MMP-2-sensitive nanosystems. Under near-neutral conditions, the maleimide group in N-(2-Aminoethyl)maleimide hydrochloride binds to thiol groups via a nucleophilic addition reaction, and can be used to modify polymers or biological interfaces, enhancing mucosal adhesion and regulating the surface charge of biological interfaces. N-(2-Aminoethyl)maleimide hydrochloride can optimize the adhesion performance of drug delivery carriers and cell interactions with biological interfaces, and is applied in transmucosal drug delivery systems (such as drug carriers for oral and bladder sites) and biomaterial surface engineering research, providing support for tissue implantation, regeneration, and related drug delivery .

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-SuccINimidyl ester	Biochemical Assay Reagents
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of *MMP-2*-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize *MMP-2*-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

m-PEG2000-NHS ester

mPEG2000-SC; mPEG2000-SuccINimidyl ester

Biochemical Assay Reagents

m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

Cat. No.	Product Name	Target	Research Area

HY-P2213

GPLGIAGQ	MMP Apoptosis	Cancer
GPLGIAGQ, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-P2213A

GPLGIAGQ TFA	MMP Apoptosis	Cancer
GPLGIAGQ TFA, a MMP2-cleavable polypeptide, is used as a stimulus-sensitive linker in both liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. GPLGIAGQ TFA can be used to synthesis unique MMP2-targeted photosensitizer in photodynamic therapy (PDT) .

HY-P5764

TRAP-14 amide	Protease Activated Receptor (PAR) Integrin MMP	Cardiovascular Disease
TRAP-14 amide, a proteinase activated receptor (PAR)-activating peptide, is a PAR agonist with an EC₅₀ of 24 μM. TRAP-14 amide significantly induces platelet aggregation through ADP- and *MMP-2*-dependent pathways with Aspirin (HY-14654)-insensitivity. TRAP-14 amide also effectively increases glycoprotein (GP) Ib and GPIIb/IIIa surface expression and ADP release .

HY-P11746

GPLGIAGQC	MMP	Cancer
GPLGIAGQC is an *MMP2*-cleavable peptide . In nanoparticle-drug conjugation systems, GPLGIAGQC is cleaved by *MMP2* between the glycine and isoleucine residues. After *MMP2*-mediated hydrolysis of GPLGIAGQC, the Fc fragment is exposed on the surface of nanoparticles .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N16129

Diplacone Nymphaeol A; PropolIN C	Structural Classification Flavonoids Flavones Paulownia tomentosa (Thunb.) Steud. Scrophulariaceae Plants Source Classification	COX Reactive Oxygen Species (ROS) Calcium Channel Ferroptosis Mitochondrial Metabolism MMP
Diplacone is an orally active geranyl flavanone. It is isolated from the fruits of Paulownia tomentosa. Diplacone reduces COX-2 levels and increases the *pro-MMP2/MMP2* ratio. It induces ferroptosis-mediated cell death. Diplacone enhances mitochondrial Ca ²⁺ influx and ROS production. It possesses anti-inflammatory and free radical-scavenging activities. Diplacone can be used in research related to ulcerative colitis and non-small cell lung cancer .

HY-N7385

Nudol	Orchidaceae Phenols Polyphenols Plants Source Classification Epigeneium rotundatum (Lindl.) Summerh.	MMP Apoptosis
Nudol is a phenanthrene compound that has anti-cancer activity. Nudol inhibits cell proliferation, induces cell apoptosis. Nudol inhibits *MMP-2M* and MMP-9 activity (K_i: 988.9 nM, 1.76 μM, respectively). Nudol can be used in the research of cancers, such as osteosarcoma .

Cat. No.	Product Name		Classification

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-SuccINimidyl ester		Polymers
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of *MMP-2*-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize *MMP-2*-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
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MMP2-IN-2

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

NaturalProducts

Oligonucleotides

Natural
Products