27 Results for "

MRC1

" in MedChemExpress (MCE) Product Catalog:
Products (27)

27 Results for "MRC1" in MCE Product Catalog:

64
64 Publications Verification
Cat. No.: HY-18234A
CAS No.: 103476-89-7
Leupeptin hemisulfate is a broad-spectrum protease inhibitor. Leupeptin hemisulfate inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin hemisulfate reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc 1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin hemisulfate inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin hemisulfate is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections [1] .
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2
2 Cited Publications
Cat. No.: HY-P81214
Synonyms: Mannose Receptor; C-type lectin domain family 13 member D; CD 206; CD206; CD206 antigen; CLEC13D; CLEC13DL; Macrophage mannose receptor; Mannose receptor C type 1; MMR; MRC 1; MRC-1; MRC1_HUMAN; Macrophage mannose receptor 1; MRC1L1; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1.

Host:  

Rabbit

Application:  

WB

Reactivity:  

Human, Rat

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1
1 Cited Publications
Cat. No.: HY-P83714M
Synonyms: MMR; MR; MRC1; macrophage mannose receptor; mannose receptor

Host:  

Rat

Application:  

FC

Reactivity:  

Mouse

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1
1 Cited Publications
Cat. No.: HY-P86350
Synonyms: MRC1; CLEC13D; CLEC13DL; MRC1L1; Macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; C-type lectin domain family 13 member D-like; Macrophage mannose receptor 1-like protein 1; CD206

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, IP, ELISA

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-18234
CAS No.: 55123-66-5
Leupeptin is a broad-spectrum protease inhibitor. Leupeptin inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc 1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections [1] .
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Cat. No.: HY-P10894
CAS No.: 2283322-63-2
Research Areas:  

Cancer

mUNO is a tumor-homing peptide (mUNO, sequence: "CSPGAK") that specifically binds to mouse CD206, targeting tumor-associated macrophages that express CD206/MRC1. mUNO can interact with human recombinant CD206 [1].
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Cat. No.: HY-RS08641
Research Areas:  

Others

MRC1 Human Pre-designed siRNA Set A contains three designed siRNAs for MRC1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS26113
Research Areas:  

Others

Mrc1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Mrc1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-18234C
CAS No.: 24125-16-4
Leupeptin Ac-LL hydrochloride is a broad-spectrum protease inhibitor. Leupeptin Ac-LL hydrochloride inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin Ac-LL hydrochloride reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc 1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin Ac-LL hydrochloride inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin Ac-LL hydrochloride is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections [1] .
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Cat. No.: HY-107509
CAS No.: 885104-09-6
Purity:  99.93%
Target:  

mGluR

Research Areas:  

Neurological Disease

LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease [1] .
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Cat. No.: HY-169859
CAS No.: 3035217-40-1
EP4 receptor antagonist 7 (Compound 14) is an antagonist of the prostaglandin E2 (PGE2) receptor subtype EP4 with an IC50 value of 1.1 nM. EP4 receptor antagonist 7 inhibits PGE2-induced β-arrestin recruitment in HEK293 cells with an IC50 value of 0.9 nM. EP4 receptor antagonist 7 decreases PGE2-induced expression of mRNA encoding IL-4, macrophage mannose receptor 1 (Mrc1), chitinase-like protein 3 (Chil3), chemokine (C-X-C) motif ligand 1 (Cxcl1), triggering receptor expressed on myeloid cells 2 (Trem2), and arginase-1 (Arg1), in RAW 264.7 macrophages. EP4 receptor antagonist 7 combined with an anti-PD-1 antibody inhibits tumor growth and increases infiltration of CD 8+ T cells into tumors in a CT26 murine colon cancer model [1].
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Cat. No.: HY-RS19618
Research Areas:  

Others

Mrc1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mrc1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-18234B
CAS No.: 24365-47-7
Leupeptin Ac-LL is a broad-spectrum protease inhibitor. Leupeptin Ac-LL inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin Ac-LL reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc 1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin Ac-LL inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin Ac-LL is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections [1] .
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Cat. No.: HY-18234AR
CAS No.: 103476-89-7
Leupeptin hemisulfate (Standard) is the analytical standard of Leupeptin hemisulfate (HY-18234A). This product is intended for research and analytical applications. Leupeptin hemisulfate is a broad-spectrum protease inhibitor. Leupeptin hemisulfate inhibits serine, cysteine and threonine proteases, and regulates autophagy. Leupeptin hemisulfate reduces the expression levels of LC3B, iNOS, Cox-2, Beclin-1 and the level of endopeptidases; increases the levels of p62, Arg 1, Msr 1 and Mrc 1; and blocks the upregulation of p-PTEN, p-NF-κB, p-PI3K, p-Akt, p-p38 and ERK1/2. Leupeptin hemisulfate inhibits NO, ROS, proinflammatory cytokines, the IFN-γ/IL-10 ratio, phagolysosome fusion, mammalian lysosomal hydrolase activity and SARS-CoV-2 replication; and reverses impaired autophagic flux. Leupeptin hemisulfate is applicable to research related to chronic inflammatory diseases, edema, skin tumorigenesis, COVID-19 and respiratory infections [1] .
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Cat. No.: HY-P11462
CAS No.: 2305574-44-9
Research Areas:  

Cancer

UNO peptide is a MRC1-expressing TAMs (MEMs)-targeting peptide. UNO peptide targets CD206 on MEMs across a spectrum of solid tumors. UNO peptide can be used in the research of MEMs in breast cancer [1].
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Cat. No.: HY-P705166
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MMR; CD206; hMR; MRC1; CLEC13D; CLEC13DL; MRC1L1
Species:  
Source:  
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Cat. No.: HY-P78736
Purity:  ≥ 95%, as determined by Bis-Tris PAGE.
Synonyms: MMR; CD206; hMR; MRC1; CLEC13D; CLEC13DL; MRC1L1
Species:  
Source:  
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Cat. No.: HY-107509R
CAS No.: 885104-09-6
Research Areas:  

Neurological Disease

LY2389575 hydrochloride (Standard) is the analytical standard of LY2389575 (hydrochloride) (HY-107509). This product is intended for research and analytical applications. LY2389575 hydrochloride is a selective and noncompetitive mGlu3 negative allosteric modulator (NAM), with an IC50 value of 190 nM. LY2389575 hydrochloride induces an increase in Mrc1 levels. LY2389575 hydrochloride also independently amplifies Amyloid beta (Aβ) toxicity and can be used in study of Alzheimer's disease [1] .
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Cat. No.: HY-P705249
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1
Species:  
Source:  
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Cat. No.: HY-P702528
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: CD206; CLEC13D; CLEC13Dmacrophage mannose receptor 1; C-type lectin domain family 13 member D; mannose receptor, C type 1; MMR; MMRCD206 antigen; MRC1
Species:  
Source:  
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