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Results for "

NAD substrate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (2) Aldehyde Dehydrogenase (ALDH) (1) Aldose Reductase (1) Bacterial (4) Biochemical Assay Reagents (4) Calcium Channel (1) Drug Derivative (1) Drug Intermediate (1) Endogenous Metabolite (14) Fluorescent Dye (3) Fungal (1) Glutamate Dehydrogenase (GLDH) (3) Isotope-Labeled Compounds (2) Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1) Mitochondrial Metabolism (3) NADH Dehydrogenase (1) NAMPT (2) Nucleoside Antimetabolite/Analog (1) PARP (8) PDHK (1) Phosphodiesterase (PDE) (2) Quinone Reductase (3) Reference Standards (3) Sirtuin (4) Toll-like Receptor (TLR) (1) UGT (1)
By Research Areas:	Cancer (12) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (3) Metabolic Disease (17) Neurological Disease (4)

By Targets:

17β-HSD (2)

Aldehyde Dehydrogenase (ALDH) (1)

Aldose Reductase (1)

Bacterial (4)

Biochemical Assay Reagents (4)

Calcium Channel (1)

Drug Derivative (1)

Drug Intermediate (1)

Endogenous Metabolite (14)

Fluorescent Dye (3)

Fungal (1)

Glutamate Dehydrogenase (GLDH) (3)

Isotope-Labeled Compounds (2)

Methylenetetrahydrofolate Dehydrogenase (MTHFD) (1)

Mitochondrial Metabolism (3)

NADH Dehydrogenase (1)

NAMPT (2)

Nucleoside Antimetabolite/Analog (1)

PARP (8)

PDHK (1)

Phosphodiesterase (PDE) (2)

Quinone Reductase (3)

Reference Standards (3)

Sirtuin (4)

Toll-like Receptor (TLR) (1)

UGT (1)

By Research Areas:

Cancer (12)

Cardiovascular Disease (1)

Infection (4)

Inflammation/Immunology (3)

Metabolic Disease (17)

Neurological Disease (4)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: MARCKS

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B0445A

NAD sodium 40+ Cited Publications β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium	Endogenous Metabolite	Metabolic Disease
NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

HY-137592

Nicotinamide 1,N6-ethenoadenine dinucleotide ε-NAD	Fluorescent Dye Phosphodiesterase (PDE) Glutamate Dehydrogenase (GLDH)	Others
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions .

HY-B0150S

Nicotinamide-d4 1 Publications Verification Niacinamide-d₄; Nicotinic acid amide-d₄	Sirtuin Endogenous Metabolite	Neurological Disease Cancer
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-128895

KL1333 1 Publications Verification	Quinone Reductase Mitochondrial Metabolism	Metabolic Disease
KL1333, a derivative of β-lapachone, is an orally available *NAD+* modulator. KL1333 reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL1333 improves energy metabolism and mitochondrial dysfunction in MELAS fibroblasts. KL1333 protects against Cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-12418

Stenoparib 2 Publications Verification E7449; 2X-121	PARP	Cancer
Stenoparib (E7449) is a potent PARP1 and PARP2 inhibitor and also inhibits TNKS1 and TNKS2, with IC₅₀s of 2.0, 1.0, ～50 and ～50 nM for PARP1, PARP2, TNKS1 and TNKS2, respectively, using ³²P-NAD ⁺ as substrate.

HY-163316

SIRT4-IN-1 2 Publications Verification	Sirtuin Glutamate Dehydrogenase (GLDH) PDHK	Metabolic Disease Cancer
SIRT4-IN-1 is a selective and potent Sirtuin 4 (Sirt4) inhibitor with an IC₅₀ of 16 μM for hSirt4. SIRT4-IN-1 also inhibits hSirt1, hSirt2, hSirt3, hSirt4 and hSirt6. SIRT4-IN-1 competes with acyl peptide substrate for Sirt4's acyl binding site, and is noncompetitive with NAD ⁺. SIRT4-IN-1 increases glutamate dehydrogenase (GDH) activity and rescues pyruvate dehydrogenase (PDH) activity. SIRT4-IN-1 inhibits adipocyte differentiation and suppresses Sirt4 overexpression-induced increased differentiation. SIRT4-IN-1 can be used for the researches of cancer and metabolic disease .

HY-125027

Isobutyl-deoxynyboquinone IB-DNQ	Quinone Reductase	Cancer
Isobutyl-deoxynyboquinone (IB-DNQ) is a selective substrate for NAD(P)H:quinone oxidoreductase (NQO1). Isobutyl-deoxynyboquinone can be used for the research of anticancer .

HY-P3185

beta-Galactose dehydrogenase	Biochemical Assay Reagents	Metabolic Disease
Beta-galactose dehydrogenase is a selective catalyst for β-galactose. Under pH 8.6 conditions, beta-galactose dehydrogenase catalyzes the oxidation of β-galactose, produced by the hydrolysis of lactose by β-galactosidase, with nicotinamide adenine dinucleotide (NAD) to produce reduced nicotinamide adenine dinucleotide (NADH). Beta-galactose dehydrogenase specifically mediates this oxidation reaction for the quantitative detection of the substrate, used in the analysis of lactose concentration in samples such as breast milk .

HY-117029

NAAD sodium 1 Publications Verification Deamido NAD sodium	Endogenous Metabolite	Metabolic Disease
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-B0306

Prothionamide Protionamide	Bacterial	Infection
Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with *NAD* to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

HY-15046

EB-47 5 Publications Verification	PARP	Cardiovascular Disease Inflammation/Immunology
EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM. EB-47 mimics the substrate NAD ⁺ and extends from the nicotinamide to the adenosine subsite .

HY-131009

Fluorescein-NAD+	PARP	Others
Fluorescein-NAD+ is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.

HY-134279

8-Br-NAD+ sodium	Calcium Channel	Others
8-Br-NAD+ sodium is an NAD+ derivative that acts as a substrate for transfer to diversely modified ADP-ribosylated molecules .

HY-B0445B

α-NAD α-Nicotinamide Adenine Dinucleotide	Mitochondrial Metabolism Endogenous Metabolite	Metabolic Disease
α-NAD (α-Nicotinamide Adenine Dinucleotide) serves as a substrate for reninase, functions as an analog of β-NAD, affects the kinetics of NAD-dependent enzymes, and also plays a critical role as a cofactor in mitochondrial redox reactions .

HY-W002555

4-Aminonicotinic acid	Drug Intermediate	Others
4-Aminonicotinic acid is a building block, that can be used for synthesis of pharmaceutical agents. 4-Aminonicotinic acid can be used as the substrate or inhibitor in the research of NAD(P)H metabolism and the activity of related enzymes .

HY-108631

EB-47 dihydrochloride 5 Publications Verification	PARP	Inflammation/Immunology
EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM. EB-47 mimics the substrate NAD ⁺?and extends from the nicotinamide to the adenosine subsite .

HY-B0150S2

Nicotinamide-13C6 Niacinamide-¹³C₆; Nicotinic acid amide-¹³C₆	Endogenous Metabolite Sirtuin	Neurological Disease Cancer
Nicotinamide- ¹³C₆ is the ¹³C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0150S1

Nicotinamide-15N,13C3 Niacinamide-¹⁵N,¹³C₃; Nicotinic acid amide-¹⁵N,¹³C₃	Isotope-Labeled Compounds Endogenous Metabolite Sirtuin	Neurological Disease Cancer
Nicotinamide- ¹⁵N, ¹³C₃ is the ¹³C-labeled and ¹⁵N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-125147

A-1293201	NAMPT	Cancer
A-1293201 is a substrate-independent NAMPT inhibitor with antitumor activity. A-1293201 effectively reduces the total cellular NAD ⁺/NADH (NADt) level, subsequently leading to ATP depletion and cancer cell death. In addition, A-1293201 can effectively overcome the acquired resistance mechanism of the NAMPT Y18 mutant to CHS-828 (HY-10079) .

HY-B0445AR

NAD sodium (Standard) β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard)	Endogenous Metabolite Reference Standards	Metabolic Disease
NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

HY-131009A

Fluorescein-NAD+ sodium	PARP	Others
Fluorescein-NAD+ sodium is an alternative to radiolabeled NAD and a substrate for ADP-ribosylation. Fluorescein-NAD+ sodium can be used in PARP assays by fluorescence microscopy. Extinction Coefficient: 262 nm.

HY-137673

2'-Deoxy-NAD+	NADH Dehydrogenase	Others
2'-Deoxy-NAD+ is a noncompetitive inhibitor for NAD ⁺ with a K_i of 32 μM. 2'-Deoxy-NAD+ can be utilized as a substrate to study the ADP-ribosyl transfer reaction .

HY-127127

Deamino-NAD	Endogenous Metabolite	Others
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-137673A

2'-Deoxy-NAD+ sodium	Endogenous Metabolite	Others
2'-Deoxy-NAD+ sodium is the sodium salt form of 2'-Deoxy-NAD+ (HY-137673). 2'-Deoxy-NAD+ sodium is a noncompetitive inhibitor of NAD+ with a Ki of 32 μM. 2'-Deoxy-NAD+ sodium can be used as a substrate to study ADP-ribosyl transfer reactions.

HY-127127A

Deamino-NAD sodium	Aldehyde Dehydrogenase (ALDH) Endogenous Metabolite	Metabolic Disease
Deamino-NAD sodium is a structural analog of NAD+ (HY-B0445). Deamino-NAD sodium is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

HY-137592A

Nicotinamide 1,N6-ethenoadenine dinucleotide sodium ε-NAD sodium	Fluorescent Dye	Others
Nicotinamide 1,N6-ethenoadenine dinucleotide (ε-NAD) sodium, a fluorescent analogue of NAD, is able to serve as a substrate for the bacterial toxincatalyzed G-ADP ribosylation of signal-transducing G-proteins. Nicotinamide 1,N6-ethenoadenine dinucleotide sodium can be used as a fluorescent substrate for the studies of the ADP ribosylation reaction .

HY-128895A

KL1333 hydrochloride	Mitochondrial Metabolism Quinone Reductase	Metabolic Disease
KL1333 hydrochloride is an orally active NAD ⁺ modulator that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, leading to increased intracellular NAD ⁺ levels through NADH oxidation. Elevated NAD ⁺ levels trigger activation of SIRT1 and AMPK, and subsequently activate PGC-1α. KL1333 hydrochloride improves energy metabolism and mitochondrial dysfunction in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) fibroblasts. KL1333 hydrochloride protects against cisplatin-induced ototoxicity in mouse cochlear cultures .

HY-134280

8-Br-NHD+ Nicotinamide 8-Br-hypoxanthine dinucleotide	Drug Derivative	Others
8-Br-NHD+ (Nicotinamide 8-Br-hypoxanthine dinucleotide) is a derivative of NAD+ (nicotinamide adenine dinucleotide) that acts as a potential substrate, competitive inhibitor or modulator of enzymes that interact with β-NAD+. 8-Br-NHD+ can be used to synthesize a cyclic ADP nucleotide (cADPR) analog .

HY-134355

ADPRP	PARP	Others
ADPRP is an intranuclear enzyme whose main activity is to use NAD+ (nicotinamide adenine dinucleotide) as a substrate to add ADP-ribose units to chromatin-bound proteins, including the ADPRP enzyme itself. This process, called poly(ADP-ribosylation), is a post-translational modification that regulates the interaction between DNA and nuclear proteins .

HY-156735

HSD17B13-IN-2	17β-HSD	Cancer
HSD17B13-IN-2 is an HSD17B13 inhibitor with human IC₅₀ values of 0.18 μM (with β-estradiol as substrate) and 0.25 μM (with Leukotriene B4 as substrate), and it exhibits selectivity for human HSD17B11. HSD17B13-IN-2 binds to the active site of HSD17B13 in an NAD ⁺-dependent manner, interacts with the bound NAD ⁺ cofactor, and stabilizes human HSD17B13 protein to prevent its aggregation. HSD17B13-IN-2 reduces the conversion of β-estradiol to estrone in cellular assays. HSD17B13-IN-2 can be used in studies related to nonalcoholic fatty liver disease .

HY-156736

HSD17B13-IN-3	17β-HSD	Cancer
HSD17B13-IN-3 (compound 2) is a potent hydroxysteroid 17ß-dehydrogenase 13 (HSD17B13) inhibitor with IC₅₀s of 0.38 μM and 0.45 μM in biochemical assays using both β-estradiol or Leukotriene B4 (LTB4) as substrate and NAD ⁺ as cofactor. HSD17B13-IN-3 shows low cell penetration .

HY-B0306S

Prothionamide-d5 Protionamide-d₅	Isotope-Labeled Compounds Bacterial	Infection
Prothionamide-d₅ is deuterium labeled Prothionamide (HY-B0306). Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with *NAD* to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

HY-B0306R

Prothionamide (Standard) Protionamide (Standard)	Reference Standards Bacterial	Infection
Prothionamide (Standard) is the analytical standard of Prothionamide (HY-B0306). This product is intended for research and analytical applications. Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with *NAD* to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

HY-134392A

6-Alkyne-NAD+ sodium	Nucleoside Antimetabolite/Analog	Others
6-Alkyne-NAD+ sodium is a nicotinamide adenine dinucleotide (NAD) analogue. 6-Alkyne-NAD+ sodium can be used as a fluorescent probe coupled with fluorescent labels for marking ADP-ribose polymerase substrate proteins .

HY-E70990

Diaphorase (NADH), Bacillus megaterium	Biochemical Assay Reagents	Metabolic Disease
Diaphorase (NADH), Bacillus megaterium (EC 1.6.99.3) is an enzyme that catalyzes the chemical reaction NAD (P)H + H+ + a quinone? NAD (P)+ + a hydroquinone. The 4 substrates of this enzyme are NADH, NADPH, H+, and quinone, whereas its 3 products are NAD+, NADP+, and hydroquinone.

HY-136263

Biotin-NAD+	PARP	Cancer
Biotin-NAD ⁺ is a PARylation donor and also a substrate of poly (ADP-ribose) polymerase-1 (PARP1). Under the mediation of PARP1, Biotin-NAD ⁺ undergoes poly (ADP-ribosyl) ation to generate biotinylated poly (ADP-ribose) polymers. Biotin-NAD ⁺ can be used for pull-down assays of PARylated proteins in renal epithelial cells. Biotin-NAD ⁺ is applicable to cancer-related research .

HY-E71009

N-Acylmannosamine 1-Dehydrogenase, Pseudomonas sp.	Biochemical Assay Reagents	Metabolic Disease
N-Acylmannosamine 1-Dehydrogenase, Pseudomonas sp. (EC 1.1.1.233) acts on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The two substrates of this enzyme are N-acyl-D-mannosamine and NAD+, whereas its 3 products are N-acyl-D-mannosaminolactone, NADH, and H+.

HY-P3186B

Glucose dehydrogenase, Pseudomonas sp.	Endogenous Metabolite	Metabolic Disease
Glucose dehydrogenase, Pseudomonas sp. (EC 1.1.1.47) is an oxidoreductase that acts on the CH-OH group of a donor molecule and uses NAD ⁺ or NADP ⁺ as an acceptor. The three substrates of glucose dehydrogenase are β-D-glucose, NAD ⁺, and NADP ⁺, while its four products are D-gluconic acid-1,5-lactone, NADH, NADPH, and H ⁺.

HY-E70891

β-Galactose Dehydrogenase S, Pseudomonas fluorescens	Endogenous Metabolite	Metabolic Disease
β-Galactose Dehydrogenase S, Pseudomonas fluorescens (EC 1.1.1.48) belongs to the oxidoreductase family and is an oxidoreductase that acts on the CH-OH group as a donor and uses NAD+ or NADP+ as an acceptor. β-Galactose Dehydrogenase S, Pseudomonas fluorescens, is involved in galactose metabolism. The enzyme's two substrates are D-galactose and NAD+, while its three products are D-galactonide-1,4-lactone, NADH, and H+.

HY-P2901A

3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni	Aldose Reductase	Metabolic Disease
3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni (EC 1.1.1.50) belongs to the oxidoreductase family. Its three substrates are androstenedione, NAD+, and NADP+, while its four products are 5α-androstane-3,17-dione, NADH, NADPH, and H+. 3α-Hydroxysteroid Dehydrogenase, Pseudomonas testosteroni, acts on the CH-OH group of the donor molecule, with NAD+ or NADP+ as the acceptor.

HY-179598

SARM1-IN-8	Toll-like Receptor (TLR)	Neurological Disease
SARM1-IN-8 (compound 6) is a competitive SARM1 base-exchange inhibitor. SARM1-IN-8 shows competitive inhibition of SARM1 ^Δ1-27 activity with respect to the NAD ⁺ substrate .

HY-DY1108

Nicotinamide 1,N6-ethenoadenine dinucleotide (solution) ε-NAD (solution)	Glutamate Dehydrogenase (GLDH) Phosphodiesterase (PDE) Fluorescent Dye	Others
Nicotinamide 1,N6-ethenoadenine dinucleotide (solution) (ε-NAD (solution)) is a fluorescent analog of NAD. Nicotinamide 1,N6-ethenoadenine dinucleotide can be cleaved by phosphodiesterase I (from C. adamanteus venom) and binds to bovine liver glutamate dehydrogenase. Nicotinamide 1,N6-ethenoadenine dinucleotide can serve as a substrate for G-ADP ribosylation of G proteins catalyzed by bacterial toxins. Nicotinamide 1,N6-ethenoadenine dinucleotide can be used as a fluorescent substrate for the study of ADP ribosylation reactions . Solvent and concentration: ddH2O: 20 mM

HY-W714186

Etaconazol Etaconazole	Bacterial Fungal	Infection
Etaconazol (Etaconazole) is an azole fungicide. Etaconazol possesses endocrine-disrupting potential and inhibits placental steroidogenesis by suppressing 3β-hydroxysteroid dehydrogenase (3β-HSD1). Etaconazol binds to the NAD ⁺/steroid-binding site of the target enzyme and acts on both the free enzyme and enzyme-substrate complex to inhibit their activity .

HY-W006081

3-Methyl-2-nitrophenol	UGT	Others
3-Methyl-2-nitrophenol is a UDP-glucuronyltransferase (EC 2.4.1.17) acceptor substrate that can be confirmed to undergo glucuronidation catalyzed by the enzyme to form a glucuronide conjugate. 3-Methyl-2-nitrophenol functions as a substrate for conjugation, with glucuronidation forming a glucuronide conjugate that eliminates the parent compound’s characteristic yellow color. 3-Methyl-2-nitrophenol has higher lipid solubility that contributes to high glucuronidation conversion rate, and exhibits lower absorbance at 340 nm to act as a less interfering substrate for the NADH-NAD ⁺-linked UDP-glucuronyltransferase assay .

HY-E70922

Yeast 6-Phosphogluconic Dehydrogenase	Endogenous Metabolite	Metabolic Disease
Yeast 6-Phosphogluconic Dehydrogenase (EC 1.1.1.44) belongs to the oxidoreductase family. It is an oxidoreductase that acts on the CH-OH group of the donor molecule and uses NAD+ or NADP+ as the acceptor. Yeast 6-Phosphogluconic Dehydrogenase has two substrates: 6-phosphate-D-gluconic acid and NADP+, and three products: D-ribulose-5-phosphate, CO2, and NADPH.

HY-E70945

6-Phosphogluconic Dehydrogenase, Sheep	Endogenous Metabolite	Metabolic Disease
6-Phosphogluconic Dehydrogenase, Sheep (EC 1.1.1.44) belongs to the oxidoreductase family. Its two substrates are 6-phosphate-D-gluconic acid and NADP+, and its three products are D-ribulose-5-phosphate, CO2, and NADPH. 6-Phosphogluconic Dehydrogenase, Sheep (EC 1.1.1.44) refers to an oxidoreductase that acts on the CH-OH group of the donor molecule and uses NAD+ or NADP+ as the acceptor.

HY-E70977

6-phospho-D-gluconate dehydrogenase, E. coli	Biochemical Assay Reagents	Metabolic Disease
6-phospho-D-gluconate dehydrogenase, E. coli (EC 1.1.1.44) is an oxidoreductase that acts on the CH-OH group of a donor molecule and uses NAD+ or NADP+ as an acceptor. The two substrates of 6-phospho-D-gluconate dehydrogenase, E. coli (EC 1.1.1.44) are 6-phospho-D-gluconate and NADP+, while its three products are D-ribulose-5-phosphate, CO2, and NADPH.

HY-108631R

EB-47 dihydrochloride (Standard)	Reference Standards PARP	Inflammation/Immunology
EB-47 dihydrochloride (Standard) is the analytical standard of EB-47 (dihydrochloride) (HY-108631). This product is intended for research and analytical applications. EB-47 dihydrochloride, a potent and selective PARP-1/ARTD-1 inhibitor with an IC₅₀ value of 45 nM, shows modest potency against ARTD5 with an IC₅₀ value of 410 nM. EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite .

HY-182567

Nampt-IN-19	NAMPT	Cancer
Nampt-IN-19 is an orally active and non-substrate nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with a human K_i of 5.6 nM. Nampt-IN-19 blocks NAD ⁺ biosynthesis from Nicotinamide (HY-B0150). Nampt-IN-19 acts as an antiproliferative agent in cancer cells. Nampt-IN-19 has preclinical pharmacokinetic properties supporting oral antitumor activity in mouse xenograft models. Nampt-IN-19 can be used for the research of colorectal cancer .

HY-182355

MTHFD2-IN-7	Methylenetetrahydrofolate Dehydrogenase (MTHFD)	Cancer
MTHFD2-IN-7 is an orally active, selective MTHFD2 inhibitor with IC₅₀ values of 0.038 μM and 7.44 μM against human hMTHFD1 and hMTHFD2, respectively. MTHFD2-IN-7 exerts its function by binding to the substrate-binding site of MTHFD2 and maintaining interactions with *NAD+. Verified by TSA and DARTS assays, MTHFD2-IN-7 not only binds effectively to the target protein, but also possesses Caco-2* permeability and liver microsomal metabolic stability. MTHFD2-IN-7 exhibits favorable pharmacokinetic properties in mice. MTHFD2-IN-7 also significantly inhibits cancer cell proliferation and reduces tumor volume, and serves as a promising small-molecule tool for acute myeloid leukemia research .

Cat. No.	Product Name	Type

HY-B0445A

NAD sodium

40+ Cited Publications

β-DPN sodium; β-NAD sodium; β-Nicotinamide Adenine Dinucleotide sodium

Biochemical Assay Reagents

NAD sodium is an orally effective cofactor and homeostatic regulator. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions that oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria, which indirectly generates ATP. NAD sodium can be used for the research of non-alcoholic fatty liver disease, obesity, and glucose intolerance .

HY-B0445AR

NAD sodium (Standard)

β-DPN sodium (Standard); β-NAD sodium (Standard); β-Nicotinamide Adenine Dinucleotide sodium (Standard)

Biochemical Assay Reagents

NAD sodium (Standard) is the analytical standard of NAD sodium. This product is intended for research and analytical applications. NAD (β-Nicotinamide Adenine Dinucleotide) sodium is an analogue of NAD. NAD sodium can be reduced to β-nicotinamide adenine dinucleotide (NADH) during coupling with reactions which oxidize organic substrates. NAD sodium can be converted to β-nicotinamide adenine dinucleotide (NADH) and passes to the inside of mitochondria that indirectly generates ATP .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-117029

NAAD sodium 1 Publications Verification Deamido NAD sodium	Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
NAAD sodium (Deamido nad sodium), a functional NAD ⁺ precursor, is the substrate of glutamine-dependent NAD ⁺ synthetase. NAAD sodium is used to study the structure of nicotinate mononucleotide adenylyltransferases .

HY-127127

Deamino-NAD	Microorganisms Source Classification	Endogenous Metabolite
Deamino-NAD is a structural analog of NAD+ (HY-B0445). Deamino-NAD is involved in glycolysis as a substrate for rabbit muscle glyceraldehyde 3-phosphate dehydrogenase (GPDH), with a K_m of 2300 pm, and a K_d of 112 pm .

Cat. No.	Product Name	Chemical Structure

HY-B0150S

Nicotinamide-d4 1 Publications Verification
Nicotinamide-d₄ is the deuterium labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0150S2

Nicotinamide-13C6
Nicotinamide- ¹³C₆ is the ¹³C-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0150S1

Nicotinamide-15N,13C3
Nicotinamide- ¹⁵N, ¹³C₃ is the ¹³C-labeled and ¹⁵N-labeled Nicotinamide. Nicotinamide is a form of vitamin B3 that plays essential roles in cell physiology through facilitating NAD+ redox homeostasis and providing NAD+ as a substrate to a class of enzymes that catalyze non-redox reactions. Nicotinamide is an inhibitor of SIRT1.

HY-B0306S

Prothionamide-d5

Prothionamide-d₅ is deuterium labeled Prothionamide (HY-B0306). Prothionamide is an orally active thioamide antibacterial agent. Prothionamide is a substrate of OCT1 with a K_m value of 805.8 μM. Prothionamide reacts with NAD to form a covalent adduct, with the adduct being a tight-binding inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae InhA. Prothionamide can effectively inhibit the growth of Mycobacterium tuberculosis (MIC = ~0.5 µg/mL) and Mycobacterium leprae. Prothionamide is used in the research of tuberculosis and leprosy .

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NAD substrate

Inhibitors & Agonists

Biochemical Assay Reagents

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Isotope-Labeled Compounds

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