1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. NAAD sodium salt

NAAD sodium salt (Synonyms: Deamido nad sodium salt)

Cat. No.: HY-117029
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NAAD sodium salt (Deamido nad sodium salt), a functional NAD+ precursor, is the substrate of glutamine-dependent NAD+ synthetase. NAAD sodium salt is used to study the structure of nicotinate mononucleotide adenylyltransferases.

For research use only. We do not sell to patients.

NAAD sodium salt Chemical Structure

NAAD sodium salt Chemical Structure

CAS No. : 104809-30-5

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Description

NAAD sodium salt (Deamido nad sodium salt), a functional NAD+ precursor, is the substrate of glutamine-dependent NAD+ synthetase. NAAD sodium salt is used to study the structure of nicotinate mononucleotide adenylyltransferases[1][2].

In Vitro

In peripheral blood mononuclear cells (PBMC), NAAD is only expected to be produced in biosynthesis of NAD+ from tryptophan and NA2, was elevated from less than 20 nM to as high as 0.91 μM[1].
Nicotinamide adenine dinucleotide synthetases (NADS) catalyze the amidation of nicotinic acid adenine dinucleotide (NAAD) to yield the enzyme cofactor nicotinamide adenine dinucleotide (NAD)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice, when nicotinic acid (NA) is provided by oral gavage, liver NA peaked (340 pmol/mg) in 15 min. Hepatic NA appearance is followed by an expected peak of 220 NAAD at 1 h post gavage and a rise in hepatic NAD+ from 990 baseline to 2200 at 2 h[1].
NAAD is reported in mouse liver when 500 mg/kg of radioactive nicotinamide (Nam) is injected intraperitoneally (IP) into the body cavity of mice. However, NAAD is observed in kidneys, ovaries, lung, heart and brain in addition to liver in mice IP-injected with 500 mg/kg of NA but not Nam[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

686.39

Formula

C₂₁H₂₅N₆NaO₁₅P₂

CAS No.
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NAAD sodium salt
Cat. No.:
HY-117029
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