23 Results for "

NK1R

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "NK1R" in MCE Product Catalog:

33
33 Publications Verification
Cat. No.: HY-P0201
CAS No.: 33507-63-0
Synonyms: Neurokinin P
Substance P (Neurokinin P) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R).
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33
33 Publications Verification
Cat. No.: HY-P0201A
CAS No.: 148470-19-3
Synonyms: Neurokinin P TFA
Substance P TFA (Neurokinin P TFA) is a CNS-penetrant neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) [1].
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1
1 Cited Publications
Cat. No.: HY-P1722
CAS No.: 129176-97-2
Target:  

Neurokinin Receptor

Research Areas:  

Inflammation/Immunology

Spantide II, an undecapeptide substance P (SP) analog, is a potent neurokinin-1 receptor (NK-1R) antagonist. Spantide II binds with NK-1R and blocks proinflammatory activities associated with SP. Spantide II can be used in the research of inflammatory skin disorders, such as psoriasis and contact dermatitis [1] .
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Cat. No.: HY-W011978
CAS No.: 1218-34-4
N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases [1] .
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Cat. No.: HY-B2078A
CAS No.: 10402-53-6
Target:  

Neurokinin Receptor

Research Areas:  

Inflammation/Immunology

Eprazinone dihydrochloride is a gent with mucolytic, secretolytic, antitussive, and bronchial antispasmodic properties. Eprazinone dihydrochloride is a neurokinin 1 receptor (NK1R) ligand. Eprazinone dihydrochloride has the potential for chronic bronchitis treatment that improved pulmonary function and arterial partial pressure of oxygen [1] .
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Cat. No.: HY-P0242
CAS No.: 86933-75-7
Neurokinin B is a tachykinin family peptide that preferentially binds to and activates NK3R over other tachykinin receptors. Neurokinin B preferentially binds to the substance P receptor (SP-N receptor) and mediates acetylcholine release from cholinergic neurons. Neurokinin B regulates the pulsatile release of Kisspeptin and GnRH, stimulates or inhibits the secretion of luteinizing hormone (HY-P2293), regulates reproductive function via metabolic signals, and drives the onset of puberty. Neurokinin B exerts vasoactive effects and induces contraction of isolated guinea pig ileum. Neurokinin B can be used in studies related to hypogonadotropic hypogonadism [1] .
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Cat. No.: HY-P0242A
CAS No.: 101536-55-4
Neurokinin B TFA is a tachykinin family peptide that preferentially binds to and activates NK3R over other tachykinin receptors. Neurokinin B TFA preferentially binds to the substance P receptor (SP-N receptor) and mediates acetylcholine release from cholinergic neurons. Neurokinin B TFA regulates the pulsatile release of Kisspeptin and GnRH, stimulates or inhibits the secretion of luteinizing hormone (HY-P2293), regulates reproductive function via metabolic signals, and drives the onset of puberty. Neurokinin B TFA exerts vasoactive effects and induces contraction of isolated guinea pig ileum. Neurokinin B TFA can be used in studies related to hypogonadotropic hypogonadism [1] .
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Cat. No.: HY-156907
CAS No.: 1274013-03-4
Purity:  99.13%
ZINC49534341 is an MRGPRX2 inverse agonist inactive against NK1R and MRGPRX4. ZINC49534341 can be used for the research of pruritus, mast cell-mediated hypersensitivity [1].
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Cat. No.: HY-P2546
CAS No.: 87468-58-4
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

Biotin-Substance P is the biotin tagged Substance P. Substance P (Neurokinin P) is a neuropeptide, acting as a neurotransmitter and as a neuromodulator in the CNS. The endogenous receptor for substance P is neurokinin 1 receptor (NK1-receptor, NK1R) [1].
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Cat. No.: HY-P0201AF
Research Areas:  

Cancer

Substance P, FAM-labeled (TFA) is Substance P TFA (HY-P02101A) labeled with FAM fluorophore. Substance P TFA (Neurokinin P TFA) is a neuropeptide that acts as a neurotransmitter and neuromodulator in the central nervous system. The endogenous receptor of Substance P is neurokinin 1 receptor (NK1R) [1].
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Cat. No.: HY-P3801
CAS No.: 77128-69-9
Synonyms: DiMe-C7
[Glp5,(Me)Phe8,Sar9] Substance P (5-11) (DiMe-C7) is a Substance P (HY-P0201) analogue that has approximately the same effects as Substance P (HY-P0201) on neurokinin 1 receptor (NK1R) in rat brain, but with a much longer duration of action. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) selectively activates dopamine metabolism in the mesencephalon and midbrain cortex of the rat brain. [Glp5,(Me)Phe8,Sar9] Substance P (5-11) also increases motor activity and induces recovery of addictive agent-seeking behavior in rats [1] .
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Cat. No.: HY-P11312
CAS No.: 2770688-17-8
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease

[S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is a neuropeptide A analog and a peptide fragment of EB1002 (HY-P10746). [S5K, F6Y, L9mL, M10Mox] neurokinin A (4-10) is highly selective for mouse tachykinin receptors and human tachykinin receptor NK1R [1].
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Cat. No.: HY-P3852
CAS No.: 153607-26-2
Synonyms: SPR393-407
Neurokinin Receptor (393-407), rat (SPR393–407) is a rat neurokinin 1 receptor (NK1R) fragment. NK1R is rapidly internalized by endocytosis and recycled to the plasma membrane when binding to substance P (SP). Neurokinin Receptor (393-407), rat can be used in the research of neurogenic inflammation [1] .
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Cat. No.: HY-W011978S
N-Acetyl-L-tryptophan-d3 is the deuterium labeled N-Acetyl-L-tryptophan (HY-W011978). N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases [1] .
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Cat. No.: HY-19670
CAS No.: 290296-68-3
Synonyms: Ro67-5930
Target:  

Neurokinin Receptor

Research Areas:  

Neurological Disease Endocrinology

Befetupitant is a high-affinity, nonpeptide, competitive tachykinin 1 receptor (NK1R) antagonist.
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Cat. No.: HY-129423
CAS No.: 552292-58-7
Target:  

Neurokinin Receptor

Research Areas:  

Others

Telmapitant is an orally active NK1R antagonist. Telmapitant has antiemetic effect and can be used for the research of delayed onset emesis [1].
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Cat. No.: HY-131463
CAS No.: 337505-63-2
Target:  

Neurokinin Receptor

Research Areas:  

Cancer

ASN-1377642 is a NK1 receptor antagonist with a Ki value of 251 nM. ASN-1377642 shows antitumor action in breast cancer cells with NK1R-Tr high expression [1] .
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Cat. No.: HY-P81073
Synonyms: Neurokinin 1; Neurokinin 1 Receptor; NK 1 receptor; NK 1R; NK1 receptor; NK-1R; NK1R; NKIR; SPR; Substance P receptor; TAC 1R; TAC1R; Tachykinin 1 receptor; Tachykinin receptor 1; Tachykinin receptor 1; TACR1; NK1-R; NK1R

Host:  

Rabbit

Application:  

WB, ELISA, IHC-P, IHC-F, FC, ICC/IF

Reactivity:  

Human, Rat, Guinea Pig

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Cat. No.: HY-P811376

Host:  

Rabbit

Application:  

WB, IHC-P, ICC/IF, FC

Reactivity:  

Human, Mouse, Rat

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Cat. No.: HY-P2139
CAS No.: 139446-71-2
Research Areas:  

Others

Ranakinin is a NK1R agonist. Ranakinin inhibits the binding of selective NK1 radioligands to NK1 receptors. Ranakinin activates phospholipase C (Phospholipase C), thereby enhancing polyphosphoinositide hydrolysis. Ranakinin stimulates inositol phosphate production and reduces membrane polyphosphoinositide levels. Ranakinin stimulates corticosterone and aldosterone secretion [1] .
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