1218-34-4
Chemical Structure
N-Acetyl-L-tryptophan
- CAS No.: 1218-34-4
- Formula:C13H14N2O3
- Molecular Weight:246.26
IUPAC Name: acetyl-L-tryptophan
InChIKey: DZTHIGRZJZPRDV-LBPRGKRZSA-N
SMILES: O=C(O)[C@H](CC1=CNC2=C1C=CC=C2)NC(C)=O
Biological Activity: N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases[1][2][3][4].
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N-Acetyl-L-tryptophan | 99.82% | N-Acetyl-L-tryptophan is an antagonist of the neurokinin-1 receptor (NK-1R), disrupting the binding of substance P (SP) to NK-1R. This action provides neuroprotective effects, improving memory deficits and motor impairments. N-Acetyl-L-tryptophan is also an inhibitor of cytochrome c (Cytochrome c), and it exerts antioxidant and anti-inflammatory effects by inhibiting the expression of IL-1β and the activation of caspase-1. N-Acetyl-L-tryptophan holds promise for research in neurodegenerative and inflammatory diseases. | ||||||||||||||||||||
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N-Acetyl-L-tryptophan (Standard) | 99.99% | N-Acetyl-L-tryptophan (Standard) is the analytical standard of N-Acetyl-L-tryptophan. This product is intended for research and analytical applications. N-Acetyl-L-tryptophan is an endogenous metabolite. | ||||||||||||||||||||
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References
- [1]. Sirianni A C, et al. N‐acetyl‐l‐tryptophan, but not N‐acetyl‐d‐tryptophan, rescues neuronal cell death in models of amyotrophic lateral sclerosis[J]. Journal of Neurochemistry, 2015, 134(5): 956-968. [Content Brief]
- [2]. Li H, et al. Inhibition of excessive mitophagy by N-acetyl-L-tryptophan confers hepatoprotection against Ischemia-Reperfusion injury in rats[J]. PeerJ, 2020, 8: e8665. [Content Brief]
- [3]. Thornton E, et al. The NK1 receptor antagonist N-acetyl-L-tryptophan reduces dyskinesia in a hemi-parkinsonian rodent model[J]. Parkinsonism & related disorders, 2014, 20(5): 508-513. [Content Brief]
- [4]. Fernandes J, et al. N-acetyl-L-tryptophan, a substance-P receptor antagonist attenuates aluminum-induced spatial memory deficit in rats[J]. Toxicology Mechanisms and Methods, 2018, 28(5): 328-334. [Content Brief]
