86933-75-7
Chemical Structure
Neurokinin B
- CAS No.: 86933-75-7
- Formula:C55H79N13O14S2
- Molecular Weight:1210.42
SMILES: CSCC[C@@H](C(N)=O)NC([C@H](CC(C)C)NC(CNC([C@H](C(C)C)NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@H](CC(O)=O)NC([C@@H](NC([C@H](CCSC)NC([C@@H](N)CC(O)=O)=O)=O)CC2=CN=CN2)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)=O
Biological Activity: Neurokinin B is a tachykinin family peptide that preferentially binds to and activates NK3R over other tachykinin receptors. Neurokinin B preferentially binds to the substance P receptor (SP-N receptor) and mediates acetylcholine release from cholinergic neurons. Neurokinin B regulates the pulsatile release of Kisspeptin and GnRH, stimulates or inhibits the secretion of luteinizing hormone (HY-P2293), regulates reproductive function via metabolic signals, and drives the onset of puberty. Neurokinin B exerts vasoactive effects and induces contraction of isolated guinea pig ileum. Neurokinin B can be used in studies related to hypogonadotropic hypogonadism[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Neurokinin B | 98.48% | Neurokinin B is a tachykinin family peptide that preferentially binds to and activates NK3R over other tachykinin receptors. Neurokinin B preferentially binds to the substance P receptor (SP-N receptor) and mediates acetylcholine release from cholinergic neurons. Neurokinin B regulates the pulsatile release of Kisspeptin and GnRH, stimulates or inhibits the secretion of luteinizing hormone (HY-P2293), regulates reproductive function via metabolic signals, and drives the onset of puberty. Neurokinin B exerts vasoactive effects and induces contraction of isolated guinea pig ileum. Neurokinin B can be used in studies related to hypogonadotropic hypogonadism. | ||||||||||||||||||||
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References
- [1]. Navarro VM. Interactions between kisspeptins and neurokinin B. Adv Exp Med Biol. 2013;784:325-47. [Content Brief]
- [2]. Jayasena CN, et al. Effects of neurokinin B administration on reproductive hormone secretion in healthy men and women. The Journal of clinical endocrinology and metabolism. 2014 Jan;99(1):E19-27. [Content Brief]
- [3]. Billings HJ, et al. Neurokinin B acts via the neurokinin-3 receptor in the retrochiasmatic area to stimulate luteinizing hormone secretion in sheep. Endocrinology. 2010 Aug;151(8):3836-46. [Content Brief]
- [4]. Laufer R, et al. Neurokinin B is a preferred agonist for a neuronal substance P receptor and its action is antagonized by enkephalin. Proceedings of the National Academy of Sciences of the United States of America. 1985 Nov;82(21):7444-8. [Content Brief]
