Neomyosuppressin
Neomyosuppressin (Dromyosuppressin) is a myosuppressive peptide. Neomyosuppressin is isolable from head extracts of Neobellieria bullata, as well as the brains and intestines of Drosophila melanogaster. Neomyosuppressin inhibits spontaneous visceral muscle movements of isolated insect hindguts and oviducts, as well as contractions of various insect visceral muscles. Neomyosuppressin slows the heart rate of adult and pupal Drosophila without altering rhythmicity.
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- CAS No.: 143458-86-0
- Formule: C58H86N16O15
- Masse moléculaire:1247.42
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
Synthetic neomyosuppressin (0.086 nM) completely inhibits spontaneous visceral muscle movements of isolated hindgut tissues from Leucophaea maderae at a threshold concentration of 0.086 nM, and exhibits reversible, dose-dependent responses[1].
Synthetic neomyosuppressin (0.34 nM) inhibits spontaneous visceral muscle movements of isolated Locusta migratoria (migratory locust) oviduct tissues at a threshold concentration of 0.34 nM, and elicits a reversible, dose-dependent response[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Canton-S (early pupae, P1 stage)[3]
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Dosage:1 mM
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Administration:injection into the dorsal caudal end near the heart; single injection
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Result:Decreased mean baseline heart rate from 2.32 Hz to 1.64 Hz, representing a significant 29.2% reduction (P<0.05).
Decreased baseline rhythmicity score from 0.68 to 0.51, a 25.4% reduction.
Chemical Information
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CAS No. 143458-86-0
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Masse moléculaire 1247.42
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Formule C58H86N16O15
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SMILES
[C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CC(O)=O)=O)[C@H](C)C)=O)CC(O)=O)=O)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)[C@@H](C)C)=O
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Synonyms
Dromyosuppressin; Neb-MS; DMS
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Sequence
Thr-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2
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Sequence Shortening
TDVDHVFLRF-NH2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Fónagy A, et al. Isolation, primary structure and synthesis of neomyosuppressin, a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1992 Jun;102(2):239-45. [Content Brief]
[2]. Lange AB, et al. The effects of SchistoFLRFamide on contractions of locust midgut. Peptides. 1998;19(3):459-67. [Content Brief]
[3]. Johnson E, et al. Native and heterologous neuropeptides are cardioactive in Drosophila melanogaster. Journal of insect physiology. 2000 Aug 01;46(8):1229-1236. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Neomyosuppressin Related Classifications
HY-P1724 Related Classifications
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Keywords
- Neomyosuppressin
- 143458-86-0
- Dromyosuppressin
- Neb-MS
- DMS
- Others
- Locusta migratoria
- insect hindgut
- Leucophaea maderae
- Drosophila heart
- Neobellieria bullata
- Drosophila melanogaster
- insect myosuppressins/FM(L)RFamide peptide family
- insect visceral muscles
- Drosophila melanogaster Canton-S pupae
- insect oviduct
- Inhibitor
- inhibitor
- inhibit