143458-86-0
Chemical Structure
Neomyosuppressin
Synonym(s): Dromyosuppressin; Neb-MS; DMS
- CAS. Nr.: 143458-86-0
- Formula:C58H86N16O15
- Molecular Weight:1247.42
IUPAC Name: (6S,9S,12S,15S,18S,21S,24S,27S)-18-((1H-imidazol-5-yl)methyl)-1-amino-6-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)carbamoyl)-27-((2S,3R)-2-amino-3-hydroxybutanamido)-12-benzyl-21-(carboxymethyl)-1-imino-9-isobutyl-15,24-diisopropyl-8,11,14,17,20,23,26-heptaoxo-2,7,10,13,16,19,22,25-octaazanonacosan-29-oic acid
InChIKey: XYBRAEZMEMTADX-XESIXFTMSA-N
SMILES: [C@@H](CC1=CN=CN1)(NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CC(O)=O)=O)[C@H](C)C)=O)CC(O)=O)=O)C(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(N)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)[C@@H](C)C)=O
Biological Activity: Neomyosuppressin (Dromyosuppressin) is a myosuppressive peptide. Neomyosuppressin is isolable from head extracts of Neobellieria bullata, as well as the brains and intestines of Drosophila melanogaster. Neomyosuppressin inhibits spontaneous visceral muscle movements of isolated insect hindguts and oviducts, as well as contractions of various insect visceral muscles. Neomyosuppressin slows the heart rate of adult and pupal Drosophila without altering rhythmicity[1][2][3].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Neomyosuppressin | Neomyosuppressin (Dromyosuppressin) is a myosuppressive peptide. Neomyosuppressin is isolable from head extracts of Neobellieria bullata, as well as the brains and intestines of Drosophila melanogaster. Neomyosuppressin inhibits spontaneous visceral muscle movements of isolated insect hindguts and oviducts, as well as contractions of various insect visceral muscles. Neomyosuppressin slows the heart rate of adult and pupal Drosophila without altering rhythmicity. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Fónagy A, et al. Isolation, primary structure and synthesis of neomyosuppressin, a myoinhibiting neuropeptide from the grey fleshfly, Neobellieria bullata. Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology. 1992 Jun;102(2):239-45. [Content Brief]
- [2]. Lange AB, et al. The effects of SchistoFLRFamide on contractions of locust midgut. Peptides. 1998;19(3):459-67. [Content Brief]
- [3]. Johnson E, et al. Native and heterologous neuropeptides are cardioactive in Drosophila melanogaster. Journal of insect physiology. 2000 Aug 01;46(8):1229-1236. [Content Brief]
