Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
P2X7 channel
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "P2X7 channel" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P1137
CAS No.: 955091-53-9
Target:
Research Areas:
Target:
Research Areas:
JNJ-42253432 is a CNS-penetrant, high-affinity and orally active P2X7 antagonist, with pKi values of 9.1 and 7.9 for rat and human P2X7 channels, respectively .
Cat. No.: HY-P705903
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: P2RX7; Purinergic Receptor P2X, Ligand Gated Ion channel, 7; Purinergic Receptor P2X 7; Purinergic Receptor P2X7; P2X7; Purinergic Receptor; Purnergic Receptor P2X 7; P2X Purinoceptor; P2X Purinoceptor 7; P2X7 Isoform Q; ATP Receptor; P2X7 Isoform O; P2Z
Species:
Human
Source:
E. coli
Cat. No.: HY-124300
CAS No.: 1627900-41-7
Target:
Research Areas:
JNJ-54166060 is a potent and selective P2X7 receptor antagonist, with IC50s of 4/115/72 nM for human/rat/mouse P2X7 receptor, respectively .
Cat. No.: HY-184711
CAS No.: 1606572-10-4
Research Areas:
Z1456467176 is an allosteric inhibitor of P2X7R. Z1456467176 binds to P2X7R, prevents ATP-induced channel opening and receptor activation, and blocks ATP-induced activation of the NLRP3-caspase-1-IL-1β pathway. Z1456467176 inhibits ATP-induced P2X7R pore formation in macrophages, as well as IL-1β secretion induced by ATP or BzATP. Z1456467176 alleviates gouty joint inflammation in rats. Z1456467176 can be used for the research of gouty arthritis .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
