1606572-10-4
Chemical Structure
Z1456467176
- CAS No.: 1606572-10-4
- Formula:C19H23ClF3N3O3S
- Molecular Weight:465.92
InChIKey: WDUMBUFWWOATNN-UHFFFAOYSA-N
SMILES: O=C(C(CC1=CC=CC(C(F)(F)F)=C1)C)NC2=CC=CC(S(=O)(NCCN)=O)=C2.Cl
Biological Activity: Z1456467176 is an allosteric inhibitor of P2X7R. Z1456467176 binds to P2X7R, prevents ATP-induced channel opening and receptor activation, and blocks ATP-induced activation of the NLRP3-caspase-1-IL-1β pathway. Z1456467176 inhibits ATP-induced P2X7R pore formation in macrophages, as well as IL-1β secretion induced by ATP or BzATP. Z1456467176 alleviates gouty joint inflammation in rats. Z1456467176 can be used for the research of gouty arthritis[1].
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Z1456467176 | Z1456467176 is an allosteric inhibitor of P2X7R. Z1456467176 binds to P2X7R, prevents ATP-induced channel opening and receptor activation, and blocks ATP-induced activation of the NLRP3-caspase-1-IL-1β pathway. Z1456467176 inhibits ATP-induced P2X7R pore formation in macrophages, as well as IL-1β secretion induced by ATP or BzATP. Z1456467176 alleviates gouty joint inflammation in rats. Z1456467176 can be used for the research of gouty arthritis. | |||||||||||||||||||||
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Keywords
