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PNP

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118

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17

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2

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6

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2

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1

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1

Antibodies

11

Click Chemistry

6

Oligonucleotides

1

GMP Molecules

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-20336
    Mc-Val-Cit-PABC-PNP
    5+ Cited Publications

    Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate

    ADC Linker Others Inflammation/Immunology Cancer
    Mc-Val-Cit-PABC-PNP is a cathepsin cleavable linker for antibody-drug conjugates (ADCs) which couples the antibody element to the effecting compound. Mc-Val-Cit-PABC-PNP can be used in the synthesis of ADCs .
    Mc-Val-Cit-PABC-PNP
  • HY-41189

    ADC Linker Cancer
    Fmoc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-Val-Cit-PAB-PNP has superior plasma stability comparable to that of non-cleavable linkers .
    Fmoc-Val-Cit-PAB-PNP
  • HY-128933
    AMP-PNP tetralithium
    3 Publications Verification

    Adenylyl-imidodiphosphate tetralithium

    Potassium Channel Metabolic Disease
    AMP-PNP (Adenylyl-imidodiphosphate) tetralithium is a non-hydrolyzable ATP analog. AMP-PNP tetralithium binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP tetralithium can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
    AMP-PNP tetralithium
  • HY-136329

    ADC Linker Cancer
    β-D-glucuronide-pNP-carbonate is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    β-D-glucuronide-pNP-carbonate
  • HY-16210
    Forodesine
    Maximum Cited Publications
    20 Publications Verification

    BCX-1777; Immucillin-H

    Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Forodesine (BCX-1777) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine could induce apoptosis in leukemic cells by increasing the dGTP levels .
    Forodesine
  • HY-147164

    ADC Linker Cancer
    MC-Gly-Gly-Phe-Gly-PAB-PNP is a linker for synthesis anti-human EGFR antibody agent conjugate .
    MC-Gly-Gly-Phe-Gly-PAB-PNP
  • HY-130777A
    AMP-PNP lithium hydrate
    3 Publications Verification

    Adenylyl imidodiphosphate lithium hydrate

    Drug Derivative Metabolic Disease
    AMP-PNP (Adenylyl imidodiphosphate) lithium hydrate is a non-hydrolyzable ATP analog. AMP-PNP lithium hydrate binds to ATP binding sites competely but is not hydrolyzed by enzymes, providing stable experimental conditions for studying ATP-dependent processes. AMP-PNP lithium hydrate can also be used to study enzyme activity, kinase regulation, DNA/RNA metabolism, ion channel function, and protein complex assembly .
    AMP-PNP lithium hydrate
  • HY-136136

    ADC Linker Cancer
    Fmoc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-Val-Ala-PAB-PNP
  • HY-141142

    ADC Linker Cancer
    Boc-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Boc-Val-Cit-PAB-PNP
  • HY-W011727A
    Pyridoxal 5'-​phosphate monohydrate
    4 Publications Verification

    Pyridoxal phosphate monohydrate

    Endogenous Metabolite Amyloid-β ERK Neurological Disease Metabolic Disease Cancer
    Pyridoxal 5'-phosphate monohydrate, the active form of vitamin B6, is an essential cofactor for multiple enzymes, including aromatic l-amino acid decarboxylase that catalyzes the final stage in the production of the neurotransmitters dopamine and serotonin. Pyridoxal 5'-phosphate monohydrate is the most important coenzyme variant in the process of vitamin B6 intracellular phosphorylation and is interconvertible with other variants, including pyridoxine 5′‐phosphate (PNP) and pyridoxamine 5′‐phosphate (PMP) .
    Pyridoxal 5'-​phosphate monohydrate
  • HY-135975

    ADC Linker Cancer
    MC-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    MC-Val-Ala-PAB-PNP
  • HY-140150

    ADC Linker PROTAC Linkers Cancer
    Azido-PEG3-Val-Cit-PAB-PNP is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . Azido-PEG3-Val-Cit-PAB-PNP is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs . Azido-PEG3-Val-Cit-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azido-PEG3-Val-Cit-PAB-PNP
  • HY-140145
    Mal-PEG4-Val-Cit-PAB-PNP
    1 Publications Verification

    ADC Linker Cancer
    Mal-PEG4-Val-Cit-PAB-PNP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-PEG4-Val-Cit-PAB-PNP
  • HY-148461

    ADC Linker Cancer
    Mal-VC-PAB-PNP is a cleavable ADC linker. Mal-VC-PAB-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-VC-PAB-PNP
  • HY-130937

    ADC Linker Cancer
    DBCO-Val-Cit-PABC-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) . DBCO-Val-Cit-PABC-PNP is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-Val-Cit-PABC-PNP
  • HY-131156

    ADC Linker Cancer
    Mal-PEG2-Val-Cit-PABA-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-PEG2-Val-Cit-PABA-PNP
  • HY-16209
    Forodesine hydrochloride
    Maximum Cited Publications
    20 Publications Verification

    BCX-1777 hydrochloride; Immucillin-H hydrochloride

    Nucleoside Antimetabolite/Analog Apoptosis Cancer
    Forodesine hydrochloride (BCX-1777 hydrochloride) is a highly potent and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50 values ranging from 0.48 to 1.57 nM for human, mouse, rat, monkey and dog PNP. Forodesine hydrochloride is a potent human lymphocyte proliferation inhibitor. Forodesine hydrochloride could induce apoptosis in leukemic cells by increasing the dGTP levels .
    Forodesine hydrochloride
  • HY-W039911

    PNP-alpha-D-Gal; PNP-α-D-Gal

    Biochemical Assay Reagents Others
    4-Nitrophenyl α-D-galactopyranoside (PNP-alpha-D-Gal) is an artificial substrate of 4-nitrophenyl (pNP) glycopyranoside for detecting α-galactosidase activity. The amount of released pNP is significantly increased when 4-Nitrophenyl α-D-galactopyranoside is used as substrates .
    4-Nitrophenyl α-D-galactopyranoside
  • HY-130932

    ADC Linker Cancer
    Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Boc-Val-Ala-PAB-PNP
  • HY-140147

    ADC Linker Cancer
    Mal-amido-PEG2-Val-Cit-PAB-PNP is a cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-amido-PEG2-Val-Cit-PAB-PNP
  • HY-112835

    PNP-G7

    Amylases Glycosidase Inflammation/Immunology
    Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside (EPS; pNP-G7) serves as a substrate for α-amylase. In the presence of an auxiliary enzyme such as α-glucosidase (α-glucosidase), Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is degraded by amylase (Amylase) to release a chromophore, enabling the measurement of amylase activity. Ethylidene-4-nitrophenyl-α-D-Maltoheptaoside is applicable for the diagnosis of pancreatitis [2].
    Ethylidene-4-nitrophenyl-a-D-Maltoheptaoside
  • HY-148425

    ADC Linker Cancer
    Mal-amide-PEG8-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-amide-PEG8-Val-Ala-PAB-PNP
  • HY-19480
    Ulodesine
    1 Publications Verification

    BCX4208

    Endogenous Metabolite Metabolic Disease
    Ulodesine is a purine nucleoside phosphorylase (PNP) inhibitor. Ulodesine inhibits PNP with IC50 value of 2.293 nM/L. Ulodesine can be used for the research of hyporucicemia .
    Ulodesine
  • HY-140144

    ADC Linker Cancer
    Mal-PEG1-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Mal-PEG1-Val-Cit-PAB-PNP
  • HY-137827

    p-Nitrophenyl β-D-Cellobioside

    Glycosidase Others
    4-Nitrophenyl β-D-Cellobioside (p-Nitrophenyl β-D-cellobioside) is a cellotriose analog. 4-Nitrophenyl β-D-Cellobioside is hydrolyzed by β-glucosidases such as TxGH116 and ThCel7B. 4-Nitrophenyl β-D-Cellobioside can also be hydrolyzed by exoglucanases and endoglucanases to produce p-nitrophenol (PNP). 4-Nitrophenyl β-D-Cellobioside can be used to detect cellulase activity .
    4-Nitrophenyl β-D-Cellobioside
  • HY-137878

    PNP-α-NeuNAc

    Biochemical Assay Reagents Others
    2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) is a classic chromogenic substrate for neuraminidase. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid releases p-nitrophenol upon enzymatic hydrolysis, allowing quantification of enzyme activity and inhibitory effects via spectrophotometry. 2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid (PNP-α-NeuNAc) acts as a sialyl donor in the process of enzyme-catalyzed trans-sialylation .
    2-O-(p-Nitrophenyl)-α-D-N-acetylneuraminic acid
  • HY-148399

    Drug-Linker Conjugates for ADC Cancer
    Mal-VC-PAB-PNP-CDN-A is a drug-Linker conjugates for ADC .
    Mal-VC-PAB-PNP-CDN-A
  • HY-114430
    Fmoc-Phe-Lys(Boc)-PAB-PNP
    1 Publications Verification

    ADC Linker Others
    Fmoc-Phe-Lys(Boc)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
    Fmoc-Phe-Lys(Boc)-PAB-PNP
  • HY-136154

    ADC Linker Cancer
    Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-Glu-(Boc)-Val-Cit-PAB-PNP
  • HY-151726

    ADC Linker Others
    Azido-PEG(4)-Val-Cit-PAB-PNP is a cleavable peptide ADC linker. Azido-PEG(4)-Val-Cit-PAB-PNP is a click chemistry reagent containing an azide group. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups.
    Azido-PEG(4)-Val-Cit-PAB-PNP
  • HY-134420

    PNP α-L-Fuc

    Biochemical Assay Reagents Others
    p-Nitrophenyl α-L-fucoside (PNP α-L-Fuc) is a substrate for the determination of α-L-fucosidase .
    p-Nitrophenyl α-L-fucoside
  • HY-P2724

    PNP

    Endogenous Metabolite Metabolic Disease
    Purine nucleoside phosphorylase, Microorganism (PNP) is a key enzyme in purine metabolism, which is involved in the purine rescue pathway. The deficiency of Purine nucleoside phosphorylase resulted in impaired T cell function. In the presence of inorganic orthophosphate as the second substrate, Purine nucleoside phosphorylase catalyzes the breaking of the glycosidic bond between ribose and deoxyribonucleoside to generate purine base and ribose (deoxyribose) -1-phosphate .
    Purine nucleoside phosphorylase, Microorganism
  • HY-P11295

    ADC Linker Cancer
    Fmoc-GGFG-PAB-PNP is an ADC linker used in the synthesis of antibody-drug conjugates (ADC) .
    Fmoc-GGFG-PAB-PNP
  • HY-134354A

    ADP-ribose-PNP disodium

    Poly(ADP-ribose) Glycohydrolase (PARG) Others
    pNP-ADPr disodium is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr disodium can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .
    pNP-ADPr disodium
  • HY-W190913

    ADC Linker Cancer
    DBCO-PEG4-Val-Cit-PAB-PNP is a cleavable ADC linker. The Val-Cit will specifically be cleaved by Cathepsin B. PNP can be substituted by amine-containing payload. DBCO enable click chemistry with azide molecules.
    DBCO-PEG4-Val-Cit-PAB-PNP
  • HY-W591374

    ADC Linker Cancer
    DBCO-PEG4-Val-Ala-PAB-PNP is a cleavable ADC linker. The Val-Ala linkers can be cleaved by Cathepsin B. The DBCO groups is commonly used for Click Chemistry reactions. PEG spacer improves the compound's aqueous solubility. PNP is a good leaving group.
    DBCO-PEG4-Val-Ala-PAB-PNP
  • HY-173161

    ADC Linker Cancer
    Mc-d-Val-d-Cit-PAB-PNP is a cleavable ADC linker that can be used for synthesizing antibody-drug conjugates (ADCs) .
    Mc-d-Val-d-Cit-PAB-PNP
  • HY-106934A
    Peldesine dihydrochloride
    1 Publications Verification

    BCX 34 dihydrochloride

    Nucleoside Antimetabolite/Analog HIV Infection Inflammation/Immunology Cancer
    Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research .
    Peldesine dihydrochloride
  • HY-W015996

    PNP-GalNAc

    Fluorescent Dye Others
    4-Nitrophenyl-N-acetyl-α-D-galactosaminide (pNP-GalNAc) can be used as a chromogenic substrate for N-acetyl-D-galactosaminase. 4-Nitrophenyl-N-acetyl-α-D-galactosaminide is cleaved by N-acetyl-D-galactosaminase to generate a yellow solution. The enzyme activity is quantitatively determined by absorbance detection .
    4-Nitrophenyl-N-acetyl-α-D-galactosaminide
  • HY-121106
    9-Deazaguanine
    1 Publications Verification

    DNA/RNA Synthesis Others
    9-Deazaguanine is a nucleoside analog with potent inhibitory activity against purine nucleoside phosphorylase (PNP) .
    9-Deazaguanine
  • HY-144628

    ADC Linker Cancer
    Fmoc-Asn-Pro-Val-PABC-PNP (compound 6) is a potent ADC Linker .
    Fmoc-Asn-Pro-Val-PABC-PNP
  • HY-151740

    ADC Linker Others
    4-Pentynoyl-Val-Ala-PAB-PNP is a cleavable ADC linker, that has been used to synthesis cryptophycin conjugates . 4-Pentynoyl-Val-Ala-PAB-PNP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    4-Pentynoyl-Val-Ala-PAB-PNP
  • HY-129350

    ADC Linker Cancer
    Fmoc-Phe-Lys(Trt)-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-Phe-Lys(Trt)-PAB-PNP
  • HY-136108

    ADC Linker Cancer
    Fmoc-Gly3-Val-Cit-PAB-PNP is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) .
    Fmoc-Gly3-Val-Cit-PAB-PNP
  • HY-134354

    ADP-ribose-PNP

    Poly(ADP-ribose) Glycohydrolase (PARG) Others
    pNP-ADPr is a colorimetric substrate that used for the first continuous Poly(ADP-ribose) glycohydrolase (PARG) and ADP-ribosyl hydrolase 3 (ARH3) activity assays. pNP-ADPr can be used for the research of poly(ADP-ribose)polymerase (PARP) enzymes .
    pNP-ADPr
  • HY-20336G

    ADC Linker Cancer
    Mc-Val-Cit-PABC-PNP GMP is a GMP grade Mc-Val-Cit-PABC-PNP (HY-20336). GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC linker. Mc-Val-Cit-PABC-PNP can be used in the synthesis of antibody-drug conjugates (ADCs) .
    Mc-Val-Cit-PABC-PNP
  • HY-147021

    ADC Linker Cancer
    MC-Val-D-Cit-PAB-PNP is a cleavable peptide linker molecule used in the synthesis of antibody-drug conjugates (ADCs). MC-Val-D-Cit-PAB-PNP contains a maleimidocaproyl (Mc) group that can be conjugated to an antibody and a p-nitrophenol (PNP) group that allows the peptide to be linked to antitumor compounds.
    MC-Val-D-Cit-PAB-PNP
  • HY-129361

    ADC Linker Cancer
    Fmoc-Ala-Ala-Asn-PABC-PNP is a peptide cleavable ADC linker .
    Fmoc-Ala-Ala-Asn-PABC-PNP
  • HY-158199

    ADC Linker Cancer
    BCN-HS-PEG2-bis(PNP) (Compound 62) is a p-nitrophenyl-containing ADC linker that can be used to further couple ADC cytotoxins with peptide linkers. BCN-HS-PEG2-bis(PNP) can conjugate with vc-PABC-MMAE (HY-15162) to form Drug-Linker Conjugates for ADC .
    BCN-HS-PEG2-bis(PNP)
  • HY-153486

    Biochemical Assay Reagents Others
    N3-VC-PAB-PNP is the intermediate of bicyclic peptide ligand STING conjugates . N3-VC-PAB-PNP is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N3-VC-PAB-PNP

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