1 Result for "

PROTAC EGFR degrader-2

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "PROTAC EGFR degrader-2" in MCE Product Catalog:

Cat. No.: HY-144304
CAS No.: 3031336-58-7
Purity:  95.61%
Target:  

PROTACs EGFR

Research Areas:  

Cancer

PROTAC EGFR degrader 2 is an EGFR-targeting PROTAC and antitumor agent. PROTAC EGFR degrader 2 induces degradation of EGFR protein via the ubiquitin-proteasome system, requiring binding to both EGFR and the VHL E3 ubiquitin ligase. PROTAC EGFR degrader 2 exerts antitumor efficacy following EGFR degradation. PROTAC EGFR degrader 2 is released from the NTR-responsive caged-PROTAC 17-1 upon activation by nitroreductase in hypoxic tumor tissues. PROTAC EGFR degrader 2 can be used for the research of non-small cell lung cancer .
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