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Results for "

Platinum

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Antibody (1) AMPK (1) Antibiotic (1) Antibody-Drug Conjugates (ADCs) (2) Apoptosis (17) Autophagy (2) Bacterial (2) Bcl-2 Family (5) Biochemical Assay Reagents (11) Cadherin (1) Calmodulin (2) CaMK (1) Caspase (2) Checkpoint Kinase (Chk) (2) COX (1) DNA Alkylator/Crosslinker (8) DNA/RNA Synthesis (9) Drug Derivative (3) Drug Intermediate (3) Drug Metabolite (1) EGFR (1) ER-phagy (1) ERK (1) Eukaryotic Initiation Factor (eIF) (1) Ferroptosis (4) Folate Receptor (FR) (2) Glutathione Peroxidase (1) IFNAR (1) IKK (1) JAK (2) Lipoxygenase (1) MAP3K (2) MAPKAPK2 (MK2) (2) MDM-2/p53 (2) MMP (1) MOFs (1) NF-κB (2) Nucleoside Antimetabolite/Analog (1) PARP (2) PD-1/PD-L1 (2) PDGFR (1) Peptide-Drug Conjugates (PDCs) (1) PERK (1) Pyroptosis (1) Reactive Oxygen Species (ROS) (6) Reference Standards (2) STAT (2) STING (2) TGF-β Receptor (1) TrxR (1) VEGFR (2)
By Research Areas:	Cancer (52) Endocrinology (2) Infection (3)

By Targets:

ADC Antibody (1)

AMPK (1)

Antibiotic (1)

Antibody-Drug Conjugates (ADCs) (2)

Apoptosis (17)

Autophagy (2)

Bacterial (2)

Bcl-2 Family (5)

Biochemical Assay Reagents (11)

Cadherin (1)

Calmodulin (2)

CaMK (1)

Caspase (2)

Checkpoint Kinase (Chk) (2)

COX (1)

DNA Alkylator/Crosslinker (8)

DNA/RNA Synthesis (9)

Drug Derivative (3)

Drug Intermediate (3)

Drug Metabolite (1)

EGFR (1)

ER-phagy (1)

ERK (1)

Eukaryotic Initiation Factor (eIF) (1)

Ferroptosis (4)

Folate Receptor (FR) (2)

Glutathione Peroxidase (1)

IFNAR (1)

IKK (1)

JAK (2)

Lipoxygenase (1)

MAP3K (2)

MAPKAPK2 (MK2) (2)

MDM-2/p53 (2)

MMP (1)

MOFs (1)

NF-κB (2)

Nucleoside Antimetabolite/Analog (1)

PARP (2)

PD-1/PD-L1 (2)

PDGFR (1)

Peptide-Drug Conjugates (PDCs) (1)

PERK (1)

Pyroptosis (1)

Reactive Oxygen Species (ROS) (6)

Reference Standards (2)

STAT (2)

STING (2)

TGF-β Receptor (1)

TrxR (1)

VEGFR (2)

By Research Areas:

Cancer (52)

Endocrinology (2)

Infection (3)

Inhibitors & Agonists

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-17394

Cisplatin Maximum Cited Publications 769 Publications Verification cis-Platinum; CDDP; cis-DiaminodichloroPlatinum	DNA Alkylator/Crosslinker Ferroptosis Autophagy Pyroptosis Lipoxygenase	Cancer
Cisplatin (CDDP) is an antineoplastic chemotherapy agent by cross-linking with DNA and causing DNA damage in cancer cells. Cisplatin activates ferroptosis and induces autophagy .

HY-Y0091

Xantphos 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene	Biochemical Assay Reagents	Others
Xantphos (9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene) is a bisphosphine ligand. Xantphos coordinates to metals in either cis or trans chelation mode. Xantphos acts as a key ligand in palladium or platinum catalyzed reactions. Xantphos can be used in the construction of heterocyclic compounds in organic synthesis .

HY-P991628

SSGJ-707 PF-08634404	PD-1/PD-L1 VEGFR	Cancer
SSGJ-707 (PF-08634404) is a bispecific antibody targeting VEGF and PD-1. SSGJ-707 exerts dual anti-tumor effects by neutralizing VEGF and blocking the PD-1 signaling pathway. SSGJ-707 can be combined with platinum-based chemotherapy to inhibit advanced non-small cell lung cancer (NSCLC), and its inhibitory effect is not limited by PD-L1 expression levels. In the HARMONi-2 trial, the objective response rate of SSGJ-707 correlates with the PD-L1 tumor proportion score, and the incidence of grade ≥3 adverse events is comparable to that of Inetetamab (HY-P99969). SSGJ-707 is being extensively investigated for a variety of malignancies including advanced NSCLC, colorectal cancer and small cell lung cancer .

HY-105930

Lobaplatin 5 Publications Verification D-19466	Apoptosis Caspase Bcl-2 Family	Cancer
Lobaplatin (D-19466) is a diastereometric mixture of platinum(II) complexe. Lobaplatin arrests cell cycle at G1 and G2/M phase. Lobaplatin induces apoptosis by increasing expressions of caspase and Bax, decreasing expression of Bcl-2. Lobaplatin can be used for research of cancer .

HY-B1022

Dimesna 1 Publications Verification BNP-7787	Drug Derivative	Endocrinology Cancer
Dimesna (BNP-7787), the disulfide form of Mesna (HY-13679), is a platinum-related toxicity protective agent. Dimesna converts to Mesna, which in turn inactivates toxic platinum substances. Dimesna does not interfere with the antitumor activity of platinum compounds. Dimesna does not affect the antiproliferative effects of Cisplatin (HY-17394) or Carboplatin (HY-17393). Dimesna counteracts Cisplatin-induced nephrotoxicity. Dimesna exerts selective protective effects on the kidneys. Dimesna can be used in studies related to ovarian cancer and Cisplatin-induced nephrotoxicity .

HY-109146

Imifoplatin PT-112	Apoptosis DNA Alkylator/Crosslinker	Cancer
Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity .

HY-126061

1,7-Dimethyluric acid	Biochemical Assay Reagents Drug Metabolite	Others
1,7-Dimethyluric acid is an N-methylated uric acid and purine derivative, as well as a caffeine metabolite. When 1,7-Dimethyluric acid is acted upon by peroxidase in the presence of H₂O₂, it follows the same oxidation pathway to generate a UV-absorbing intermediate, which decays via first-order kinetics. 1,7-Dimethyluric acid can adsorb onto pyrolytic graphite electrodes, but not onto glassy carbon electrodes or platinum electrodes. The N-methylation modification of its pyrimidine ring prevents ring contraction of the diol intermediate, and no NMR evidence of O-alkylation is observed during propylation under the test conditions .

HY-112030

Dipotassium tetrachloroplatinate Potassium tetrachloroplatinate(Ⅱ)	Biochemical Assay Reagents	Cancer
Dipotassium tetrachloroplatinate (Potassium tetrachloroplatinate (Ⅱ)) is an important reagent for the preparation of other platinum coordination complexes. Dipotassium tetrachloroplatinate acts as a radiosensitizer to enhance the killing effect of hyperthermia. Dipotassium tetrachloroplatinate serves as a catalyst. Dipotassium tetrachloroplatinate exhibits antitumor activity .

HY-114842

TDRL-551 1 Publications Verification	DNA/RNA Synthesis	Cancer
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC₅₀ = 18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the anti-cancer efficacy of Platinum (Pt)-based chemotherapy. TDRL-551 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC) .

HY-16129

CBP-501	Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K	Cancer
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer .

HY-P99705

Lifastuzumab vedotin RG-7599; DNIB-0600A; NaPi2b-ADC	Antibody-Drug Conjugates (ADCs)	Cancer
Lifastuzumab vedotin (RG-7599; DNIB0600A) is an antibody-drug conjugate (ADC) that comprises a humanized IgG1 anti-NaPi2b monoclonal antibody (MNIB2126A) and a potent antimitotic agent, monomethyl auristatin E (MMAE), which inhibits cell division by blocking the polymerization of tubulin. Lifastuzumab vedotin has the potential for non-small cell lung cancer (NSCLC) and platinum-resistant ovarian cancer (PROC) research .

HY-W096169D

*Platinum*	Biochemical Assay Reagents Drug Intermediate	Cancer
Platinum is a metallic element, and its complexes act as orally active anticancer agents. Platinum-based complexes used for tumors include Cisplatin (HY-17394), Carboplatin (HY-17393), and Oxaliplatin (HY-17371) .

HY-W034985

Tetrakis(triphenylphosphine)platinum Tetrakis(triphenylphosphine)Platinum(0)	Biochemical Assay Reagents	Others
Tetrakis(triphenylphosphine)platinum is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W075885

*trans-Platinum(II)diammine dichloride* trans-Platinumdiamminedichloride	DNA Alkylator/Crosslinker	Others
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-131468

Picoplatin AMD473; ZD0473	DNA/RNA Synthesis	Cancer
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA .

HY-162133

MSA-2-Pt	STING Apoptosis IKK IFNAR NF-κB	Cancer
MSA-2-Pt, platinum salt-modified MSA-2 (HY-136927), is a STING agonist. MSA-2-Pt inducing cell death by platinum and activating the STING pathway by MSA-2. MSA-2-Pt direct activates STING pathway, induces phosphorylation of TBK1, IRF3, and NF-κB p65. MSA-2-Pt enhances tumor infiltration of CD4 ⁺ and CD8 ⁺ T cells, and induces tumor cell death and apoptosis in mouse colon carcinoma and melanoma models .

HY-106588

Heptaplatin SKI 2053R	DNA Alkylator/Crosslinker	Cancer
Heptaplatin (SKI 2053R) is a platinum derivative with anticancer activity against various cancer cell lines, including cisplatin-resistant tumor cell lines. SKI-2053R is active in the research of gastric adenocarcinoma and has favorable toxicity profiles .

HY-139813

Phenanthriplatin	DNA Alkylator/Crosslinker	Cancer
Phenanthriplatin is a monovalent platinum(II)-based complex with a large cytotoxicity against cancer cells .

HY-150184

And1-IN-1	DNA/RNA Synthesis	Cancer
And1-IN-1 is a potent And1 inhibitor with an IC₅₀ of 2.08 μM. And1-IN-1 binds to the N-terminus of And-1 and induces a conformational change in And-1, which promotes the interaction of And-1 with E3 ligase CUL4B for ubiquitin-mediated degradation. And1-IN-1 suppresses the growth of a broad range of cancers and resensitizes platinum-resistant ovarian cancer cells to platinum agents. And1-IN-1 can be used for the studies of ovarian cancer and breast cancer .

HY-W007712

2-Bromo-3-methylpyridine 1 Publications Verification 2-Bromo-3-picoline	Drug Intermediate	Cancer
2-Bromo-3-methylpyridine (2-Bromo-3-picoline) is a heterocyclic intermediate of the halomethylpyridine family. 2-Bromo-3-methylpyridine can be used in the synthesis of platinum(IV) diazide complexes .

HY-151883

APE1-IN-2	Apoptosis MDM-2/p53	Cancer
APE1-IN-2 (compound AP1) is a Pt(IV) proagent, targeting a critical BER protein, apurinic/apyrimidinic endonuclease 1 (APE1). APE1-IN-2 shows anticancer activity. APE1-IN-2 induces intracellular accumulation of platinum and activates DNA damage response and apoptosis signals .

HY-179392

*Sunitinib-platinum(IV) prodrug-1*	Apoptosis DNA Alkylator/Crosslinker VEGFR PDGFR	Cancer
Sunitinib-platinum(IV) prodrug-1 (Complex A) is a Pt(IV) prodrug based on Cisplatin (HY-17394), and this design aims to enable Pt(IV) to be reduced to active Pt(II) under intracellular reducing conditions, while simultaneously releasing a derivative of Sunitinib (HY-10255A) with tyrosine kinase inhibitor (TKI) activity. Sunitinib-platinum(IV) prodrug-1 exhibits excellent cytotoxicity against renal cell carcinoma (RCC), causing DNA crosslinking and apoptosis. Sunitinib-platinum(IV) prodrug-1 inhibits the VEGFR/PDGFR signaling pathway, suppressing tumor growth and angiogenesis. Sunitinib-platinum(IV) prodrug-1 can be used for research on renal cell carcinoma .

HY-W112941

(meso-Tetraphenylporphinato)platinum Pt(II) Meso-Tetraphenylporphine	MOFs	Others
Meso- tetraphenylporphyrin - pt(ii) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-120420

N4Py	Antibiotic	Cancer
N4Py is a pentadentate ligand, that forms a stable complex with metal ions, such as iron, platinum, and copper. N4py mimics the metal binding domains of iron-dependent antibiotics like Bleomycin(HY-17565), forms the DNA-cleaving FeII-N4Py complexes, generates reactive oxygen species (ROS), and causes oxidative damage in cells. N4py can be used in cancer research .

HY-179418

*Ceritinib-platinum(IV)-4-phenylbutyrate*	Apoptosis	Cancer
Ceritinib-platinum(IV)-4-phenylbutyrate (complex 7) is a Ceritinib (HY-15656)-conjugated Platinum(IV) prodrug with anticancer activity. Ceritinib-platinum(IV)-4-phenylbutyrate induces S-phase arrest, DNA damage responses, and apoptosis. Ceritinib-platinum(IV)-4-phenylbutyrate combines cytotoxicity with immune and anti-invasive activation in cancer cell models. Ceritinib-platinum(IV)-4-phenylbutyrate can be used for cancer research, such as non-small cell lung cancer (NSCLC) .

HY-W033728

Platinum(COD)dichloride	Bacterial	Infection
Platinum(COD)dichloride (Compound Pt1) is an Antibacterial agent. Platinum(COD)dichloride shows antibacterial activity against a panel of gram-positive bacteria including Vancomycin (HY-B0671) and Methicillin (HY-121544) resistant Staphylococcus aureus .

HY-175257

*Theophylline-platinum(IV) prodrug-1*	PARP Reactive Oxygen Species (ROS) Apoptosis NF-κB ERK Bcl-2 Family TGF-β Receptor EGFR Cadherin	Cancer
Theophylline-platinum(IV) prodrug-1 is a PARP-1 inhibitor. Theophylline-platinum(IV) prodrug-1 enhances DNA damage, ROS production, mitochondrial dysfunction, apoptosis and S-phase arrest, along with reducing invasion and metastasis in cells. Theophylline-platinum(IV) prodrug-1 exhibits superior antitumor activity in the xenograft SKOV3-BRCA1-KD tumor model. Theophylline-platinum(IV) prodrug-1 can be used for the study of ovarian cancer .

HY-W414604

*Dichloro(1,2-diaminocyclohexane)platinum(II)*	Biochemical Assay Reagents	Cancer
Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum (II) analog and the oxaliplatin parent complex. Dichloro(1,2-diaminocyclohexane)platinum(II) is a potent chemotherapeutic with a wide spectrum of anticancer activity, low toxicity, and lack of cross resistance in many cisplatin-resistant cancers .

HY-105522

Ormaplatin Tetraplatin; NSC 363812	Drug Derivative	Cancer
Ormaplatin (Tetraplatin) is a Platinum (HY-W096169D) analog with anticancer activity. Ormaplatin demonstrates cytotoxic activity in Cisplatin (HY-17394)-sensitive cell lines in vitro and in vivo. Ormaplatin can be used for non-small cell lung, colon, and breast cancer research .

HY-W556802

5-Oxodecanoic acid	Biochemical Assay Reagents	Others
Dichloro(1,2-diaminocyclohexane)platinum(II) is a platinum (II) analog and the oxaliplatin parent complex. Dichloro(1,2-diaminocyclohexane)platinum(II) is a potent chemotherapeutic with a wide spectrum of anticancer activity, low toxicity, and lack of cross resistance in many cisplatin-resistant cancers .

HY-W034990

Pt(acac)2 Platinum(II) acetylacetonate

HY-P10782

Pt(IV)-M13	Peptide-Drug Conjugates (PDCs)	Cancer
Pt(IV)-M13 is a BBB-penetrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma .

HY-16129A

CBP-501 acetate	Calmodulin MAP3K MAPKAPK2 (MK2) Checkpoint Kinase (Chk)	Cancer
CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer .

HY-125010

Dicycloplatin	DNA/RNA Synthesis Apoptosis	Cancer
Dicycloplatin is a DNA damage inducer. Dicycloplatin induces DNA damage by activating biphosphorylated checkpoint kinase 2 (CHK2), breast cancer 1 (BRCA1) and triphosphorylated p53. Dicycloplatin can induce cell cycle arrest, inhibit proliferation and lead to apoptosis in prostate cancer PC3 cells and lung cancer NCI/H446 cells. Dicycloplatin can be used in cancer researchr .

HY-126060

9-Ethylguanine	Nucleoside Antimetabolite/Analog	Cancer
9-Ethylguanine is a modified nucleobase derived from guanine that coordinates to azolato-bridged dinuclear platinum(II) complexes via its N7 nitrogen atom. 9-Ethylguanine forms adducts with a ruthenium(II) complex via the N7 position of its guanine moiety .

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents	Others
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents	Others
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

HY-106768

Trimelamol CB 10-375; NSC 283162	DNA Alkylator/Crosslinker	Cancer
Trimelamol (CB10-375; NSC283162) is a highly efficient acid-catalyzed DNA interstrand crosslinker with low neurotoxicity due to its limited BBB penetration. Trimelamol exhibits anti-tumor activity and overcomes platinum resistance. Trimelamol is investigated for lung and ovarian cancer research ^{[1][2][3][4][5]}.

HY-176149

*Fluoxetine-Conjugated Platinum(IV) prodrug-1*	CaMK MMP AMPK Apoptosis Autophagy	Cancer
Fluoxetine-Conjugated Platinum(IV) prodrug-1 (Compound 8) is an eEF2K inhibitor. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits cancer cell proliferation, induces DNA damage, cell cycle arrest at S phase and apoptosis. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces ROS accumulation and mitochondrial dysfunction. Fluoxetine-Conjugated Platinum(IV) prodrug-1 inhibits TNBC cell migration and invasion by inhibiting MMP-2 activity. Fluoxetine-Conjugated Platinum(IV) prodrug-1 induces autophagy in TNBC cells by activating AMPK. Fluoxetine-Conjugated Platinum(IV) prodrug-1 has antitumor activity and activates immunosuppression in the 4T1-Luc mouse model. Fluoxetine-Conjugated Platinum(IV) prodrug-1 can be used in triple-negative breast cancer (TNBC) research .

HY-105530

Zeniplatin CL 286558	Biochemical Assay Reagents	Cancer
Zeniplatin is a third-generation, water-soluble platinum compound that has shown broad antitumor activity. Zeniplatin can be used for cancer research .

HY-161623

ERCC1/XPA interaction inhibitor 1	DNA/RNA Synthesis	Cancer
ERCC1/XPA interaction inhibitor 1 (compound 27o) is a potent ERCC1/XPA67-80 interaction inhibitor with an EC₅₀ value of 4.7 µM. ERCC1/XPA interaction inhibitor 1 has the potential for the research of DNA damaging agents and overcoming resistance to platinum-based chemotherapy .

HY-155012

Mcl-1 inhibitor 16	Bcl-2 Family	Cancer
Mcl-1 inhibitor 16 (Compound 9) is a mitochondrial targeting Platinum-based inhibitor of Mcl-1. Mcl-1 inhibitor 1 induces Bax/Bak-dependent apoptosis in cancer cells. Mcl-1 inhibitor 16 can be used alone or together with ABT-199 (HY-15531) and shows anti-tumor activity .

HY-B1022A

Dimesna free acid BNP-7787 free acid	Drug Derivative	Endocrinology Cancer
Dimesna (BNP-7787) free acid, the disulfide form of Mesna (HY-13679), is a platinum-related toxicity protective agent. Dimesna free acid converts to Mesna, which in turn inactivates toxic platinum substances. Dimesna free acid does not interfere with the antitumor activity of platinum compounds. Dimesna free acid does not affect the antiproliferative effects of Cisplatin (HY-17394) or Carboplatin (HY-17393). Dimesna free acid counteracts Cisplatin-induced nephrotoxicity. Dimesna free acid exerts selective protective effects on the kidneys. Dimesna free acid can be used in studies related to ovarian cancer and Cisplatin-induced nephrotoxicity .

HY-129909

Anticancer agent 173	Apoptosis	Infection Cancer
Anticancer agent 173 (compound 19) is a potent thioxodihydroquinazolinone analogs when combined with platinum drugs in inducing apoptotic cancer cells death .

HY-163383

L-Ent-oxPt(IV) L-EOP	Bacterial	Infection
L-Ent-oxPt IV (L-EOP) is a Oxaliplatin (HY-17371)-based siderophore-platinum conjugate. L-Ent-oxPt IV exhibits selectivity towards Escherichia coli and antibacterial activity through DNA damage .

HY-157222

Antitumor agent-125	Apoptosis Ferroptosis	Cancer
Antitumor agent-125 (compound 17A) is a novel platinum(IV) prodrug. Antitumor agent-125 can activate the mitochondrion-dependent apoptosis pathway. Antitumor agent-125 induces ferroptosis in HCT-116/OXA .

HY-155807

DPP	STAT JAK Apoptosis	Cancer
DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety .

HY-168877

FMP	MDM-2/p53 Reactive Oxygen Species (ROS) Apoptosis Caspase PARP Bcl-2 Family	Cancer
FMP is a Platinum(IV) complexe. FMP significantly upregulates the expression of γ-H2AX and p53. FMP increases the production of ROS. FMP markedly upregulates the expressions of Apoptosis-related proteins (DR5, Fas, caspase-8, Cyt-c, caspase-3, cleaved-PARP1, Bax). FMP shows antiproliferative activity against breast cancer .

HY-155808

STAT3-IN-18	STAT JAK Apoptosis COX	Cancer
STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.

HY-U00279B

Nitracrine hydrochloride	DNA/RNA Synthesis	Cancer
Nitracrine hydrochloride is a platinum-based antineoplastic drug with selective toxicity to hypoxic cells. Nitracrine hydrochloride exhibits significant cytotoxicity against the Chinese hamster ovary cell line AA8 under hypoxic conditions. Nitracrine hydrochloride exerts its effect by binding to the insertion of DNA and forming covalent adducts. The cytotoxicity of Nitracrine hydrochloride under hypoxic conditions is related to its reductive metabolism to form alkylated substances. At the same time, it may enhance the reactivity to DNA through the insertion of DNA, thereby improving the efficacy. Nitracrine hydrochloride can also inhibit RNA synthesis, contributing to its anti-tumor effect .

Cat. No.	Product Name	Type

HY-Y0091

Xantphos 9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene	Biochemical Assay Reagents
Xantphos (9,9-Dimethyl-4,5-bis(diphenylphosphino)xanthene) is a bisphosphine ligand. Xantphos coordinates to metals in either cis or trans chelation mode. Xantphos acts as a key ligand in palladium or platinum catalyzed reactions. Xantphos can be used in the construction of heterocyclic compounds in organic synthesis .

HY-W096169D

*Platinum*	Biochemical Assay Reagents
Platinum is a metallic element, and its complexes act as orally active anticancer agents. Platinum-based complexes used for tumors include Cisplatin (HY-17394), Carboplatin (HY-17393), and Oxaliplatin (HY-17371) .

HY-W034985

Tetrakis(triphenylphosphine)platinum Tetrakis(triphenylphosphine)Platinum(0)	Biochemical Assay Reagents
Tetrakis(triphenylphosphine)platinum is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W075885

*trans-Platinum(II)diammine dichloride* trans-Platinumdiamminedichloride	Biochemical Assay Reagents
trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links .

HY-W007712

2-Bromo-3-methylpyridine 1 Publications Verification 2-Bromo-3-picoline	Biochemical Assay Reagents
2-Bromo-3-methylpyridine (2-Bromo-3-picoline) is a heterocyclic intermediate of the halomethylpyridine family. 2-Bromo-3-methylpyridine can be used in the synthesis of platinum(IV) diazide complexes .

HY-W112941

(meso-Tetraphenylporphinato)platinum Pt(II) Meso-Tetraphenylporphine	Biochemical Assay Reagents
Meso- tetraphenylporphyrin - pt(ii) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-W009022

Diantipyrylmethane	Biochemical Assay Reagents
Diantipyrylmethane is a chromogenic reagent commonly used for the determination of the contents of metals such as Au (III), Ti (IV), Ir, Fe (III), molybdenum, neodymium, U (IV), iridium, platinum and rhenium via spectrophotometry and extraction photometry. Diantipyrylmethane can also form a fluorescent complex with Er (III) ions, which is applied to the determination of erbium .

HY-W073183

Dibenzo-24-crown-8-ether	Biochemical Assay Reagents
Dibenzo-24-crown-8-ether is a phase transfer catalyst that can reduce H ²PtCl ⁶·6H ²O and FeCl ²·4H ²O in a thermal system to synthesize 17 nm monodispersed iron-platinum (FePt) alloy nanoparticles .

HY-W075885R

trans-Platinum(II)diammine dichloride (Standard)

trans-Platinumdiamminedichloride (Standard)

Biochemical Assay Reagents

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) (Standard) is an analytical standard for trans-Platinum(II)diammine dichloride (HY-W075885). This product is intended for research and analytical applications. trans-Platinum(II)diammine dichloride is a geometric isomer of Cisplatin (HY-17394). trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage but exhibits low cytotoxicity. trans-Platinum(II)diammine dichloride can be used to study DNA-protein cross-links.

Cat. No.	Product Name	Target	Research Area

HY-16129

CBP-501	Calmodulin Checkpoint Kinase (Chk) MAPKAPK2 (MK2) MAP3K	Cancer
CBP-501, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 is used for various types of cancer .

HY-P11050

SP94 peptide, Cys conjugated 1 Publications Verification	Peptides	Cancer
SP94 peptide, Cys conjugated is a hepatocellular carcinoma (HCC)-targeting peptide conjugated with Cys. SP94 peptide, Cys conjugated can be used for synthesis of stimuli-responsive peptide nanomaterials (SRPNs) like platinum nanocluster assemblies (PT-NA) and it promotes the entry of PT-NA into HCC cells by mediating endocytosis. SP94 peptide, Cys conjugated can be used for cancers research .

HY-P10782

Pt(IV)-M13	Peptide-Drug Conjugates (PDCs)	Cancer
Pt(IV)-M13 is a BBB-penetrable Platinum (IV) prodrug-perfluoroaryl macrocyclic peptide conjugate. Pt(IV)-M13 is cytotoxic to glioma stem cells and increases uptake of platinum in the brain. Pt(IV)-M13 can be used in the study of glioblastoma .

HY-16129A

CBP-501 acetate	Calmodulin MAP3K MAPKAPK2 (MK2) Checkpoint Kinase (Chk)	Cancer
CBP-501 acetate, a cell-permeable calmodulin-binding peptide and a G2-abrogating drug candidate, inhibits the activity of multiple Ser ²¹⁶-specific kinases, such as MAPKAP-K2, C-Tak1, CHK1 and CHK2, with IC₅₀ values of 0.9 μM, 1.4 μM 3.4 μM and 6.5 μM, respectively. CBP-501 acetate is used for various types of cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991628

SSGJ-707 PF-08634404	PD-1/PD-L1 VEGFR	Cancer
SSGJ-707 (PF-08634404) is a bispecific antibody targeting VEGF and PD-1. SSGJ-707 exerts dual anti-tumor effects by neutralizing VEGF and blocking the PD-1 signaling pathway. SSGJ-707 can be combined with platinum-based chemotherapy to inhibit advanced non-small cell lung cancer (NSCLC), and its inhibitory effect is not limited by PD-L1 expression levels. In the HARMONi-2 trial, the objective response rate of SSGJ-707 correlates with the PD-L1 tumor proportion score, and the incidence of grade ≥3 adverse events is comparable to that of Inetetamab (HY-P99969). SSGJ-707 is being extensively investigated for a variety of malignancies including advanced NSCLC, colorectal cancer and small cell lung cancer .

HY-P992124

Onvontatug BAT8006 Antibody; BAT-6028	Folate Receptor (FR)	Cancer
Onvontatug (BAT8006 Antibody) is a humanized monoclonal antibody targeting folate receptor α (FRα). Onvontatug can be used to construct antibody-drug conjugates (ADCs), such as BAT8006. It is applicable to research related to platinum-resistant ovarian cancer .

HY-P992003

IKS012 Antibody IKS01 Antibody	ADC Antibody	Cancer
IKS012 Antibody (Isumab01) is a monoclonal antibody inhibitor targeting folate receptor α (FRA). IKS012 Antibody can be used to synthesize the antibody-drug conjugate (ADC) IKS012. IKS012 Antibody can be used to research related to platinum-resistant ovarian cancer .

HY-P992004

KHK2805 RA15-7, HuRA15-7Acc	Folate Receptor (FR)	Cancer
KHK2805 (RA15-7) is a humanized antibody against folate receptor α (FOLR1), with a K_d of 0.647 nM for human FOLR1. KHK2805 binds to a unique epitope of FOLR1 and mediates antibody-dependent cellular cytotoxicity and complement-dependent cytotoxicity against FOLR1-expressing cells. KHK2805 exhibits cytotoxicity against both ovarian cancer cells and Platinum (HY-W096169D)-resistant ovarian cancer cells. KHK2805 can be used for the research of tumors such as ovarian cancer .

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