1339960-28-9
1339960-28-9
Chemical Structure
Imifoplatin
Synonym(s): PT-112
- CAS No.: 1339960-28-9
- Formula:C6H16N2O7P2Pt
- Molecular Weight:485.23
InChIKey: SCMHTXQHAHWVSX-BNTLRKBRSA-L
SMILES: O=[P]([O-][Pt+2]1([O-][P]2(O)=O)[NH2][C@@](CCCC3)([H])[C@]3([H])[NH2]1)(O2)O
Biological Activity: Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Imifoplatin | 95.0% | Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity. | ||||||||||||||||||||
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Imifoplatin (Standard) | ≥98% | Imifoplatin (Standard) is the analytical standard of Imifoplatin (HY-109146). This product is intended for research and analytical applications. Imifoplatin (PT-112) is a platinum-based active molecule and a member of the phosphaplatins family. Imifoplatin can induce Apoptosis and exhibits antitumor activity. | ||||||||||||||||||||
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References
- [1]. Moghaddas S, et, al. Phosphaplatins, next generation platinum antitumor agents: A paradigm shift in designing and defining molecular targets. Inorganica Chimica Acta. 2012 Dec; 393(1): 173-181.
- [2]. Yamazaki T, et al. PT-112 induces immunogenic cell death and synergizes with immune checkpoint blockers in mouse tumor models. Oncoimmunology. 2020 Feb 11;9(1):1721810. [Content Brief]
- [3]. Soler-Agesta R, et al. PT-112 induces mitochondrial stress and immunogenic cell death, targeting tumor cells with mitochondrial deficiencies[J]. Cancers, 2022, 14(16): 3851. [Content Brief]
Keywords
