TDRL-551
Based on 2 publication(s) in Google Scholar
TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50 = 18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the anti-cancer efficacy of Platinum (Pt)-based chemotherapy. TDRL-551 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Purity: 98.89%
- CAS No.: 1644626-43-6
- Formula: C25H23ClIN3O4
- Molecular Weight:591.83
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
HY-L034
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Anti-Lung Cancer Compound Library
HY-L075
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Heterocyclic Compound Library
HY-L138
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) TDRL-551
MoreAll DNA/RNA Synthesis Isoforms
More
Biological Activity
TDRL-551 shows anti-cancer activity in EOC cell lines with an IC50 of 25 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:H460 NSCLC xenograft tumor mice models[1]
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Dosage:200 mg/kg
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Administration:Intraperitoneally injection, at days 8, 10, 14, 17 and 20
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Result:Reduced tumor volume.
Had no body weight loss.
Demonstrated the slowest tumor growth companied with Carboplatin (HY-17393) .
Chemical Information
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CAS No. 1644626-43-6
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Appearance Solid
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Molecular Weight 591.83
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Formula C25H23ClIN3O4
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Color Off-white to light yellow
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SMILES
O=C(CCCC(N1N=C(CC1C2=CC3=CC=C(C=C3N=C2Cl)OCC)C4=CC=C(C=C4)I)=O)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (2)
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Journal Impact Factor
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Most Recent
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Mol Cell
FANCA-dependent FEN1 recruitment suppresses transcription-replication conflicts and PARPi sensitivity. [Abstract]2026 Jun 16:S1097-2765(26)00351-5. PMID: 42302790 -
Res Sq
FANCA Deficiency Induces Oncogenic R-Loop Dependent Synthetic Lethality with PARP1 Inhibitors. [Abstract]2025 Jul 3:rs.3.rs-6080272. PMID: 40630542
Solvent & Solubility
DMSO : 62.5 mg/mL (105.60 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6897 mL | 8.4484 mL | 16.8967 mL | 42.2419 mL |
| 5 mM | 0.3379 mL | 1.6897 mL | 3.3793 mL | 8.4484 mL | |
| 10 mM | 0.1690 mL | 0.8448 mL | 1.6897 mL | 4.2242 mL | |
| 15 mM | 0.1126 mL | 0.5632 mL | 1.1264 mL | 2.8161 mL | |
| 20 mM | 0.0845 mL | 0.4224 mL | 0.8448 mL | 2.1121 mL | |
| 25 mM | 0.0676 mL | 0.3379 mL | 0.6759 mL | 1.6897 mL | |
| 30 mM | 0.0563 mL | 0.2816 mL | 0.5632 mL | 1.4081 mL | |
| 40 mM | 0.0422 mL | 0.2112 mL | 0.4224 mL | 1.0560 mL | |
| 50 mM | 0.0338 mL | 0.1690 mL | 0.3379 mL | 0.8448 mL | |
| 60 mM | 0.0282 mL | 0.1408 mL | 0.2816 mL | 0.7040 mL | |
| 80 mM | 0.0211 mL | 0.1056 mL | 0.2112 mL | 0.5280 mL | |
| 100 mM | 0.0169 mL | 0.0845 mL | 0.1690 mL | 0.4224 mL |
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