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TDRL-551 

Cat. No.: HY-114842
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TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation.

For research use only. We do not sell to patients.

TDRL-551 Chemical Structure

TDRL-551 Chemical Structure

CAS No. : 1644626-43-6

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Description

TDRL-551 is a potent replication protein A (RPA) inhibitor (IC50=18 µM). TDRL-551 inhibits RPA-DNA interaction and increases the efficacy of Platinum (Pt)-based chemotherapy in lung and ovarian cancer. RPA plays essential roles in both nucleotide excision repair (NER) and homologous recombination (HR), along with its role in DNA replication and DNA damage checkpoint activation[1].

Molecular Weight

591.83

Formula

C25H23ClIN3O4

CAS No.
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TDRL-551
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HY-114842
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