Picoplatin
Based on 1 Customer Validation
Picoplatin (AMD473) is a platinum-based antineoplastic agent. Picoplatin is specifically to circumvent thiol-mediated drug resistance by sterically hindering its reaction with glutathione (GSH) while still retaining the ability to form cytotoxic lesions with DNA.
For research use only. We do not sell to patients.
- Purity: 98.5%
- CAS No.: 181630-15-9
- Formula: C6H10Cl2N2Pt
- Molecular Weight:376.15
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All DNA/RNA Synthesis Isoforms
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Biological Activity
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 181630-15-9
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Appearance Solid
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Molecular Weight 376.15
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Formula C6H10Cl2N2Pt
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Color Light yellow to yellow
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SMILES
[Cl-][Pt+2]([N]1=C(C)C=CC=C1)([NH3])[Cl-]
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Synonyms
AMD473; ZD0473
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMF : 25 mg/mL (66.46 mM; Need ultrasonic; DMSO can inactivate Picoplatin's activity)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMF | 1 mM | 2.6585 mL | 13.2926 mL | 26.5851 mL | 66.4628 mL |
| 5 mM | 0.5317 mL | 2.6585 mL | 5.3170 mL | 13.2926 mL | |
| 10 mM | 0.2659 mL | 1.3293 mL | 2.6585 mL | 6.6463 mL | |
| 15 mM | 0.1772 mL | 0.8862 mL | 1.7723 mL | 4.4309 mL | |
| 20 mM | 0.1329 mL | 0.6646 mL | 1.3293 mL | 3.3231 mL | |
| 25 mM | 0.1063 mL | 0.5317 mL | 1.0634 mL | 2.6585 mL | |
| 30 mM | 0.0886 mL | 0.4431 mL | 0.8862 mL | 2.2154 mL | |
| 40 mM | 0.0665 mL | 0.3323 mL | 0.6646 mL | 1.6616 mL | |
| 50 mM | 0.0532 mL | 0.2659 mL | 0.5317 mL | 1.3293 mL | |
| 60 mM | 0.0443 mL | 0.2215 mL | 0.4431 mL | 1.1077 mL |
Picoplatin Related Classifications
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