2. Search Result
Search Result
Results for "

Pol-β

" in MedChemExpress (MCE) Product Catalog:

5

Inhibitors & Agonists

1

Natural
Products

1

Antibodies

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N2566
    Euscaphic acid
    1 Publications Verification

    		 DNA/RNA Synthesis PI3K Apoptosis Cancer
    Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM . Euscaphic acid induces apoptosis .
    Euscaphic acid
  • HY-120105
    NSC666715

    		DNA/RNA Synthesis Apoptosis MDM-2/p53 Bcl-2 Family Caspase PARP Cancer
    NSC666715 is a DNA polymerase β (Pol-β) inhibitor. NSC666715 directly and specifically interacts with Pol-β, interferes with its binding to damaged DNA, blocks its dRP lyase activity, and inhibits Pol-β-mediated SN- and LP-BER. NSC666715 induces AP site accumulation and S-phase cell cycle arrest, and triggers senescence and apoptosis (apoptosis) via the p53/p21 pathway in colorectal cancer cells. NSC666715 enhances TMZ (HY-17364)-induced DNA damage, senescence and apoptosis, and potentiates the cytotoxicity of TMZ. NSC666715 inhibits tumor growth in colon cancer xenograft models. NSC666715 can be used in research related to colorectal cancer .
    NSC666715
  • HY-164402
    NSC-124854

    		DNA/RNA Synthesis Cancer
    NSC-124854 is a DNA polymerase β (Pol-β) inhibitor with an IC50 of 5.3 μM. NSC-124854 has antitumor activity .
    NSC-124854
  • HY-178063
    DNA polymerase-IN-7

    		DNA/RNA Synthesis Cancer
    DNA polymerase-IN-7 is a noncompetitive inhibition of DNA Polymerase β with an IC50 of 112 nM and a Ki of 35 nM. DNA polymerase-IN-7 can inhibit DNA pol β lyase activity and the binding of the lyase domain of Pol β to DNA. DNA polymerase-IN-7 can be used for the research of cancer, such as cervical cancer .
    DNA polymerase-IN-7
  • HY-180545
    S-Chromene

    		DNA/RNA Synthesis Neurological Disease
    S-Chromene is a selective DNA polymerase-β (DNA pol-β) inhibitor. S-Chromene exhibits strong electrostatic complementarity with DNA pol-β but weak interaction with primase p58 .
    S-Chromene

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: