1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
    Apoptosis
  2. DNA/RNA Synthesis
    PI3K
    Apoptosis
  3. Euscaphic acid

Euscaphic acid 

Cat. No.: HY-N2566
Handling Instructions

Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM. Euscaphic acid induces apoptosis.

For research use only. We do not sell to patients.

Euscaphic acid Chemical Structure

Euscaphic acid Chemical Structure

CAS No. : 53155-25-2

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Description

Euscaphic acid, a DNA polymerase inhibitor, is a triterpene from the root of the R. alceaefolius Poir. Euscaphic inhibits calf DNA polymerase α (pol α) and rat DNA polymerase β (pol β) with IC50 values of 61 and 108 μM[1]. Euscaphic acid induces apoptosis[2].

IC50 & Target

IC50: 61 μM (calf DNA polymerase α); 108 μM (rat DNA polymerase β)[1]; apoptosis[2]

In Vitro

Euscaphic acid induces apoptosis and cell cycle arrest in NPC cells by suppression of the PI3K/AKT/mTOR signaling pathway[2].

Molecular Weight

488.70

Formula

C₃₀H₄₈O₅

CAS No.

53155-25-2

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Euscaphic acid
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