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Cat. No.: HY-164402

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NSC-124854

NSC-124854 is a DNA polymerase β (Pol-β) inhibitor with an IC₅₀ of 5.3 μM. NSC-124854 has antitumor activity.

For research use only. We do not sell to patients.

CAS No.: 1033942-30-1
Formula: C₉H₁₅IN₃O₇P
Molecular Weight:435.11

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NSC-124854 Chemical Structure

CAS No.: 1033942-30-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

NSC-124854 is a DNA polymerase β (Pol-β) inhibitor with an IC₅₀ of 5.3 μM. NSC-124854 has antitumor activity^[1].

IC₅₀ & Target

DNA Polymerase

All DNA/RNA Synthesis Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	<50 μM Compound: 159; NSC-124854	Anticancer activity against human HCT-116 cells assessed as reduction in cell viability Anticancer activity against human HCT-116 cells assessed as reduction in cell viability	[PMID: 33445154]

Chemical Information

CAS No. 1033942-30-1
Molecular Weight 435.11
Formula C₉H₁₅IN₃O₇P
SMILES

OP(OCC1OC(N2C(I)CC(N)=NC2=O)CC1O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jaiswal AS, et al. DNA polymerase β as a novel target for chemotherapeutic intervention of colorectal cancer. PLoS One. 2011 Feb 2;6(2):e16691. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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NSC-124854

All DNA/RNA Synthesis Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

NSC-124854 Related Classifications

HY-164402 Related Classifications